Endothelial inflammation memory after sepsis and pneumonia
Official title: Mechanisms of Endothelial Inflammatory Memory in Post-Sepsis Pneumonia and Sepsis
Funded at Albany Medical College · NIH-11572337 · Data updated 2026-11-12
A scientist is studying how blood vessel cells “remember” sepsis and why survivors get worse when they catch pneumonia, with the goal of finding better ways to reduce organ damage.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Albany Medical College NIH-funded |
| Lab location | 1 site (Albany, United States) |
| Project start | September 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $604,681 |
| NIH project number | 1R56AI189694-01A1 |
| Project ID | NIH-11572337 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients who have survived sepsis and are at risk of or have pneumonia could benefit from insights that translate into better treatments.
✕Less likely to help
Direct patient treatment changes will require further clinical testing beyond this study.
What this research studies
This project uses a clinically relevant animal model of sepsis followed by a pneumonia infection to study endothelial cells in the lungs and kidneys. It looks at how epigenetic changes and key transcription factors may prime blood vessels to respond more strongly to second infections. The study will examine the roles of STAT3, JunB, and EZH2 over several time points after the second infection to understand inflammatory memory. Findings could point to new targets for therapies that prevent organ failure in sepsis survivors who face later infections.
Why it matters
Potential benefit: If successful, the research could lead to new therapies that protect organs and reduce complications after sepsis and subsequent pneumonia.
How similar studies have gone: Previous work shows endothelial inflammation memory can influence responses, supporting the potential for this line of investigation.
Where this research is happening
-
Albany Medical College
Albany, United States Active
Researchers
- Principal investigator: Bossardi Ramos, Ramon — Albany Medical College
- Study coordinator: Bossardi Ramos, Ramon
Related research
Other NIH-funded projects on the same topics.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Optimizing Recovery After Sepsis and Pneumonia
A patient-facing program aims to improve recovery for people who survived sepsis and pneumonia after hospital discharge.
-
Host-targeted therapy to prevent lung injury from pneumonia-caused sepsis
A patient-focused look at how boosting the body’s own defenses in the lungs could lessen lung and organ damage during severe pneumonia linked to sepsis from bacteria.
-
Understanding ARDS, pneumonia, and sepsis: a big study to map how illness and recovery unfold
A large patient study at the University of Pennsylvania will follow adults with ARDS, pneumonia, or sepsis to learn how these conditions progress and recover over time.
-
Coordination and data sharing for ARDS, pneumonia, and sepsis research
A national collaborative effort to improve how researchers study ARDS, pneumonia, and sepsis by coordinating centers, data collection, and analyses.
-
Molecular profiling of ARDS, pneumonia, and sepsis in adults using advanced sequencing
A research team at four California hospitals will study adults with ARDS, pneumonia, or sepsis to identify molecular patterns in their illness using genetic sequencing.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.