Understanding ARDS, pneumonia, and sepsis: a big study to map how illness and recovery unfold
Official title: Phenotyping ARDS, Pneumonia, and Sepsis over time to elucidate shared and distinct trajectories ofillness and recovery
Funded at University of Pennsylvania · NIH-11325875 · Data updated 2026-11-12
A large patient study at the University of Pennsylvania will follow adults with ARDS, pneumonia, or sepsis to learn how these conditions progress and recover over time.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $669,634 |
| NIH project number | 5U01HL168419-04 |
| Project ID | NIH-11325875 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults hospitalized with ARDS, pneumonia, or sepsis who consent to participate and provide follow-up data and biospecimens.
✕Less likely to help
Patients not eligible for follow-up or who choose not to participate may not directly benefit from this study.
What this research studies
This project enrolls a robust human cohort of adults with ARDS, pneumonia, or sepsis to collect clinical data and blood-based molecular markers over time. Researchers will combine clinical information with molecular profiles to identify subtypes and pathways linked to organ failure and long-term disability. The goal is to develop better risk tools and prediction methods that can guide care and recovery planning. The study uses joint modeling and longitudinal analysis to connect inflammation, vascular dysfunction, muscle loss, and neural injury to patient outcomes. This effort aims to translate complex data into practical insights for clinicians and patients facing APS.
Why it matters
Potential benefit: If successful, patients with APS could receive more accurate prognoses and tailored treatments that improve survival and reduce long-term disability.
How similar studies have gone: Previous work shows that molecular subtypes can influence outcomes in critical illness, supporting the potential of this approach.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Meyer, Nuala Jennings — University of Pennsylvania
- Study coordinator: Meyer, Nuala Jennings
Related research
Other NIH-funded projects on the same topics.
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Coordinating ARDS, Pneumonia, and Sepsis research to improve care
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Coordination and data sharing for ARDS, pneumonia, and sepsis research
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Molecular profiling of ARDS, pneumonia, and sepsis in adults using advanced sequencing
A research team at four California hospitals will study adults with ARDS, pneumonia, or sepsis to identify molecular patterns in their illness using genetic sequencing.
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Investigating the molecular characteristics of ARDS, pneumonia, and sepsis
This study is looking at the differences in the biology of people with Acute Respiratory Distress Syndrome (ARDS), pneumonia, and sepsis to better understand how these conditions affect recovery, and it's inviting 1,000 participants from California to help by sharing their health information and samples over the next y
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Improving care for patients with ARDS, pneumonia, and sepsis
This study is all about improving care for people with serious lung issues like ARDS, pneumonia, and sepsis by gathering and analyzing data from a diverse group of patients, so we can better understand these conditions and find the best treatments for everyone.
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Understanding the recovery patterns of patients with ARDS, pneumonia, and sepsis
This study is looking for people who have had serious breathing problems, like ARDS, pneumonia, or sepsis, to learn more about their recovery and find ways to better predict and improve their health outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.