Examining Monocyte Profiles in Critically Ill Patients with Pseudomonas Aeruginosa Sepsis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the characteristics of blood monocytes in critically ill patients suffering from sepsis caused by Pseudomonas aeruginosa. It aims to determine whether the pro-inflammatory M1 or anti-inflammatory M2 monocyte phenotype predominates in these patients and how this relates to the severity of sepsis and patient outcomes. The study employs flow cytometry to analyze surface marker expression and ELISA to assess cytokine patterns in blood samples. Additionally, an ex-vivo model for Pseudomonas-induced sepsis will be validated to further understand the immune response.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* age \> 18 years
* critically ill patients with sepsis
* microbiologically proven infection with Pseudomonas aeruginosa

Exclusion Criteria:

* life expectancy \< 24 hours
* participation in other studies

Where it's running

• Clinic of Anesthesiology
  Ulm, Germany Recruiting

Study contacts

• Principal investigator: Manfred Weiss, MD, MBA — University Ulm, University Hospital Ulm
• Study coordinator: Manfred Weiss, MD, MBA
• Email: manfred.weiss@uniklinik-ulm.de
• Phone: +49 731 500 60226

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Sulbactam-Durlobactam for CRAB infections in real-world care

  This real-world study tests whether sulbactam-durlobactam works and is safe for adults with carbapenem-resistant Acinetobacter baumannii infections, compared with other anti-CRAB treatments.

  Recruiting Sichuan Provincial People's Hospital · Chengdu, Sichuan · NCT07601711

• Investigating how transposable elements affect immune aging in sepsis patients

  This study looks at how certain genetic elements might affect the immune system and health outcomes in people with sepsis in the ICU.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06809868

• Effects of suctioning on pain and stress in intubated ICU patients

  This study is testing if suctioning the breathing tube in ICU patients causes more pain and stress compared to not suctioning.

  Recruiting Loma Linda University · Loma Linda, California · NCT06692400

• Understanding risk factors and biomarkers in ARDS, sepsis, and pneumonia

  This study is trying to find out what causes acute respiratory distress syndrome, sepsis, and pneumonia by collecting health information and samples from hospitalized adults to help improve treatment for these conditions.

  Recruiting at 20 sites Vanderbilt University Medical Center · Fresno, California and 19 other locations · NCT06521502

• Validation of hematological indices in cardiac surgery patients

  This study is testing if certain blood test results can help predict infections and organ problems in patients who are having heart surgery.

  Recruiting Petrovsky National Research Centre of Surgery · Moscow · NCT06476171

• Testing SGLT2 inhibitors for treating sepsis in adults

  This study is testing if a new type of diabetes medication can help adults with sepsis recover better and feel safer.

  Recruiting at 2 sites Hospital Authority, Hong Kong · Hong Kong, Hong Kong and 2 other locations · NCT06473844

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.