Using the Lung Sliding Index to distinguish common lung diseases
Official title: Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary Diseases: A Prospective Case-Control Study
Run by Assiut University · NCT06983366 · Data updated 2026-11-12
This project will test whether the Lung Sliding Index (LSI) measured by bedside ultrasound can tell apart various lung conditions in adults with lung disease and in healthy volunteers.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 700 (estimated) |
| Sponsor | Assiut University Academic / other |
| Locations | 1 site (Asyut) |
| Status | Recruiting |
| Started | May 30, 2025 |
| Main results expected | November 1, 2026 |
| Study ends | December 1, 2026 |
| Registry record updated | September 22, 2026 |
| Trial ID | NCT06983366 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18 or older with a confirmed diagnosis of pneumothorax, ILD/IPF, COPD/emphysema, bronchiectasis, community-acquired pneumonia, pulmonary edema, pleural effusion, or healthy volunteers who can consent and undergo lung ultrasound are ideal candidates.
✕Probably not a fit
Patients who are mechanically ventilated, cannot tolerate ultrasound, have extensive chest wall pathology that precludes imaging, or have more than two unscorable zones are unlikely to benefit from participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational case-control study will enroll adults with a range of pulmonary diagnoses and healthy controls and perform standardized 12-zone lung ultrasound scans on each participant. Each zone will receive an LSI score (0–3) for a total score of 0–36, with operators undergoing unified training and calibration before enrollment. A subset of participants will have repeat and blinded independent reads to measure intra- and interobserver reliability. Clinical data including spirometry, blood gases, symptom scores, and 6-minute walk tests will be collected and diagnostic utility will be analyzed using ROC curves while satisfaction and feasibility are measured with validated Likert questionnaires.
Why it matters
Potential benefit: If successful, the LSI could give clinicians a quick, bedside ultrasound score to help differentiate causes of respiratory symptoms and speed more appropriate treatment decisions.
How similar studies have gone: While lung ultrasound is well established for diagnoses like pneumothorax and pleural effusion, the LSI as a standardized quantitative 12-zone score is relatively novel and has had limited prior validation beyond preliminary reports.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 18 years and older. * Diagnosed with one of the specified pulmonary diseases, or a healthy control * Able to provide written informed consent Exclusion Criteria: * Inability to tolerate or undergo a lung ultrasound * Extensive chest wall pathology precluding assessment * Unscorable \>2 zones per protocol * Withdrawal of consent * Mechanically-ventilated patients
Where it's running
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Assiut University- Faculty of Medicine
Asyut, Egypt Recruiting
Study contacts
- Principal investigator: Ahmad M. Shaddad, MD — Assiut University
- Study coordinator: Ahmad M. Shaddad, MD
- Email: shaddad_ahmad@yahoo.com
- Phone: +201111171930
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.