Challenging the equivalence of two antibiotics for P. aeruginosa pneumonia (IMPACT study)
Official title: Challenging the Paradigm of Equivalence: A Comparative Effectiveness Study of Cefepime Versus Piperacillin-Tazobactam for the Treatment of P. Aeruginosa Pneumonia - The IMPACT Study
Funded at University of Michigan at Ann Arbor · NIH-11447595 · Data updated 2026-11-12
This project compares two common antibiotics, cefepime and piperacillin-tazobactam, to see which works better for treating pneumonia caused by Pseudomonas aeruginosa in ICU patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | September 10, 2026 |
| Project end | August 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $841,065 |
| NIH project number | 1R01AI195740-01A1 |
| Project ID | NIH-11447595 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults hospitalized with pneumonia caused by Pseudomonas aeruginosa at participating centers.
✕Less likely to help
Patients treated with either antibiotic outside the study population or with non-Pseudomonas pneumonia may not experience the study-related benefits.
What this research studies
If you or a loved one develops Pseudomonas pneumonia in the ICU, this study looks at real-world outcomes from two widely used antibiotics to see which provides better clinical success and less resistance. The study collects data from seven centers in a prospective, observational way to reflect everyday care. Researchers will analyze how the drugs perform in patients, aiming to inform doctors on which option may offer better results in typical ICU settings.
Why it matters
Potential benefit: Findings could help doctors choose the most effective treatment for P. aeruginosa pneumonia and potentially reduce antibiotic resistance.
How similar studies have gone: Prior data suggest potential differences but robust comparative evidence in this setting is limited, making this study substantially informative.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Pogue, Jason Michael — University of Michigan at Ann Arbor
- Study coordinator: Pogue, Jason Michael
Related research
Other NIH-funded projects on the same topics.
-
Coordinating ARDS, Pneumonia, and Sepsis research to improve care
A national coordinating center helps researchers studying ARDS and related infections work together more efficiently to learn what helps patients recover.
-
Endothelial inflammation memory after sepsis and pneumonia
A scientist is studying how blood vessel cells “remember” sepsis and why survivors get worse when they catch pneumonia, with the goal of finding better ways to reduce organ damage.
-
Bacterial Biofilm Therapy with a Human Antibody to Help Antibiotics Work Better
A human antibody drug is being studied to disrupt bacterial biofilms and help standard antibiotics clear infections, especially around implants and catheters, in adults.
-
A tissue slice model to test treatments for Pneumocystis pneumonia in people with HIV/AIDS
Researchers are creating a lung-slice model to study Pneumocystis jirovecii pneumonia and test potential treatments using tissue from infected, immunosuppressed mice to better predict what might help people with HIV/AIDS.
-
Measuring respiratory and gut bacteria to predict pneumonia treatment failure
A project to understand how bacterial load in the lungs and gut changes during and after antibiotics for hospital-acquired and ventilator-associated pneumonia, with the goal of predicting which patients might fail treatment.
-
Better tests and treatments for Pneumocystis (PCP) pneumonia
Developing more accurate tests and safer treatment options for people with weakened immune systems who get Pneumocystis pneumonia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.