Proactive pharmacist e-consults to optimize lung health for people with HIV
Official title: Optimizing Medications and Lung Health in People With HIV Through Pharmacist-led Proactive E-Consults (OPTIMIZE Lung-HIV)
Run by Seattle Institute for Biomedical and Clinical Research · NCT07507435 · Data updated 2026-11-12
This trial tests whether proactive pharmacist-led e-consults can help people with HIV improve lung-health medications, vaccinations, smoking cessation, and deprescribing of certain inhaled medicines or PPIs.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 480 (estimated) |
| Sponsor | Seattle Institute for Biomedical and Clinical Research Academic / other |
| Locations | 3 sites (Boise, Idaho and 2 other locations) |
| Status | Recruiting |
| Started | September 24, 2026 |
| Main results expected | March 2029 |
| Study ends | September 2029 |
| Registry record updated | November 9, 2026 |
| Trial ID | NCT07507435 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with HIV on ART, under VA care, who smoke or are on inhaled corticosteroids or PPIs for extended periods.
✕Probably not a fit
Patients not receiving care at VA sites or not on relevant medications may have limited benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
OPTIMIZE Lung-HIV is a multicenter randomized trial that uses a pharmacist-led electronic consultation approach to identify and implement evidence-based changes in pulmonary care for people with HIV. Pharmacists review patient records, provide tailored recommendations, and pre-enter orders for smoking cessation, vaccinations, and deprescribing where appropriate. The intervention aims to reduce pneumonia risk and improve lung outcomes by integrating recommendations into routine care without overriding provider autonomy. The study compares the intervention to usual care in a 1:1 randomization, with recommendations delivered before patient visits to streamline clinical workflow. The setting involves Veterans Health Administration sites and existing pharmacist integration in care teams.
Why it matters
Potential benefit: If successful, patients could see reduced pneumonia risk and better lung health through optimized medications and vaccination updates.
How similar studies have gone: Prior work from the same research group showed improved COPD care with pharmacist-led e-consults in people with HIV, supporting the approach's potential.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria:
* PWH with an active prescription of ART any time in past 6 months and \<200 copies/mL within past 12 months, actively receiving care at the VA, and one of the following:
1. Actively smoking
2. Prescribed ICS for \>90 days
3. Prescribed a PPI for \>90 days
Exclusion Criteria:
* Enrolled in palliative care or hospice
* If a non-VA provider is the main primary care or HIV provider
* Are currently participating in a separate ongoing interventional clinical trial
Where it's running
-
VA Puget Sound Health Care System
Seattle, Washington, United States Recruiting -
Boise VA Medical Center
Boise, Idaho, United States Not yet recruiting -
Minneapolis VA Health Care System
Minneapolis, Minnesota, United States Not yet recruiting
Study contacts
- Principal investigator: Kristina A. Crothers, MD — VA Puget Sound Health Care System
- Study coordinator: John R Kundzins, BS
- Email: OPTIMIZEStudyTeam@va.gov
- Phone: 206-277-1182
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.