Using diaphragmatic ultrasound to diagnose acute respiratory distress in emergency patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional multicenter diagnostic study aims to evaluate the effectiveness of diaphragmatic ultrasound as a diagnostic tool for patients experiencing acute respiratory distress in emergency departments. The primary focus is on measuring the Sum of Plateau Times (SPT) to diagnose pneumonia during acute respiratory distress. Secondary objectives include assessing other ultrasound parameters and their relevance in diagnosing conditions like chronic obstructive pulmonary disease and acute cardiogenic pulmonary edema. Eligible patients will undergo a diaphragmatic ultrasound performed by trained physicians, followed by the collection of clinical and biological data from medical records.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients 18 years of age or older;
* Patient with ARD defined by respiratory rate (RR) strictly superior to 25 and/or signs of struggle which are: thoraco-abdominal rocking, active abdominal breathing, recruitment of extra-diaphragmatic respiratory muscles AND
* peripheral saturation (SpO2) strictly inferior to 90% and/or hypercapnic acidosis (pH strictly inferior to 7.35 and pCO2 strictly superior to 45mmHg) on arterial blood gases;
* Spontaneous ventilation.
* Patients presenting a clinical severity score of Grade 1 with signs of struggle, as well as those with Grade 2 and Grade 3. A clinical severity score will be used as follows: Grade 1: Minimal polypnoea with respiratory rate (RR) between 20 and 25 ; Grade 2: Moderate polypnoea with respiratory rate (RR) between 25 and 35; Grade 3: Major polypnoea with respiratory rate (RR) between 35 to 50.

Exclusion Criteria:

* Adult protected by law (guardianship, curatorship, legal protection)
* Refusal of consent after information
* Patient on non-invasive ventilation ;
* Patient on mechanical ventilation;
* Respiratory rate superior to 50/min
* Patient currently being treated for infectious pneumopathy with antibiotics;
* Pregnant or breast-feeding women;
* Patients with any known history of diaphragmatic pathologies.
* Illiterate or unable to understand the purpose and methodology of the study.
* Patient not affiliated to a social security scheme or not benefiting from such a scheme.
* Person deprived of liberty (by judicial or administrative decision, or forced hospitalization)
* Person participating in another study with an exclusion period still in progress,

Where it's running

• University Hospital of Montpellier
  Montpellier, Hérault, France Recruiting
• University Hospital of Nîmes
  Nîmes, Gard, France Not yet recruiting

Study contacts

• Principal investigator: Dino Tikvesa, Md — University Hospital, Montpellier
• Study coordinator: Dino Tikvesa, Md
• Email: d-tikvesa@chu-montpellier.fr
• Phone: 0467337974

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.