Condition

Dyspnea clinical trials and research

• 36Clinical trials
• 12NIH research projects
• 1New in 30 days
• 16Countries

Newest Dyspnea clinical trials

All recruiting trials (36)

• Wintergreen oil inhalation for shortness of breath in pneumonia patients

  Hospitals will test whether inhaling wintergreen essential oil helps relieve dyspnea in adults with pneumonia.

  Recruiting Far Eastern Memorial Hospital · New Taipei City, Taipei · NCT07894835

• Difference in finger, earlobe, and forehead oxygen levels to predict outcomes in dyspnea

  In adults with breathing trouble, this study tests whether differences in SpO2 readings from different body sites can predict who might have worse outcomes.

  Recruiting Yonsei University · Seoul, Seoul · NCT07824414

• See if video telemedicine with a caller’s mobile camera improves care for adults with acute dyspnea

  This study tests whether adding video calls from a caller’s mobile phone to the emergency dispatch process helps improve care for adults with acute shortness of breath.

  Recruiting at 10 sites Poitiers University Hospital · Angers and 9 other locations · NCT07726628

• CardioStory device in helping tell heart failure from other causes in people with shortness of breath

  This study tests whether the CardioStory noninvasive device can help emergency department clinicians distinguish heart failure from other causes of dyspnea in adults.

  Recruiting at 2 sites CardioStory INC · Monastir, Monastir Governorate and 1 other locations · NCT07685106

• Normal lung and heart function references for healthy US veterans who served in Southwest Asia

  This study tests whether healthy veterans aged 24–68 who did not have exposure to airborne hazards have normal lung and heart function values that can serve as reference standards.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07641413

• Breathing Exercises After Open-Heart Surgery

  This trial tests whether segmental breathing or active cycle breathing technique help people who just had open-heart surgery feel less short of breath and improve their heart and lung function.

  Recruiting at 3 sites University of Baghdad · Baghdad, Baghdad Governorate and 2 other locations · NCT07591987

• Breathing-muscle training during chemotherapy for early-stage breast cancer

  This tests whether breathing exercises using a small hand-held device can strengthen inhalation muscles, reduce shortness of breath, and help activity levels in women receiving chemotherapy for early-stage breast cancer.

  Recruiting Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT07386444

• Bedside ultrasound of the IVC to find pulmonary edema in adults with sudden severe breathlessness

  This project will test whether bedside ultrasound measurements of how the inferior vena cava changes with breathing can help identify pulmonary edema in adults who come to the emergency department with sudden breathing failure.

  Recruiting Università degli Studi del Piemonte Orientale Amedeo Avogadro · Novara · NCT07324980

• Repeatability of the combined exercise and heart ultrasound test (CPETecho)

  We will test whether repeating the combined exercise and heart ultrasound test gives consistent results in people with breathlessness or heart conditions who can complete a maximal exercise test.

  Recruiting Ziekenhuis Oost-Limburg · Genk · NCT07281534

• Hand fan to prevent ticagrelor-related breathlessness

  This study will try to see if using a handheld fan can reduce breathing discomfort in adults with acute coronary syndrome who are starting ticagrelor.

  Recruiting Acibadem University · Istanbul, Avcılar and 1 other locations · NCT07268859

• Hypnosis for Breathlessness Mastery in People with Persistent Dyspnea

  This study tests whether hypnosis can help people with persistent breathlessness from cancer, COPD, ILD, or heart failure feel more in control of their dyspnea.

  Recruiting University Hospital, Geneva · Geneva, Canton of Geneva · NCT07173348

• Early exercise-based rehabilitation for adults hospitalized with acute pulmonary embolism

  This trial tries an early, supervised exercise and education program for adults hospitalized with acute pulmonary embolism to see if it prevents long-term breathlessness and improves quality of life.

  Recruiting at 6 sites Insel Gruppe AG, University Hospital Bern · Aarau and 5 other locations · NCT07143539

• Using lung (pleuropulmonary) ultrasound to help diagnose sudden severe breathlessness

  This study tests whether performing pleuropulmonary (lung) ultrasound during prehospital emergency care helps clinicians identify the cause of severe dyspnea in adults.

  Recruiting University Hospital, Toulouse · Toulouse · NCT07104578

• Breathlessness during ventilator weaning in obese ICU patients

  This project will measure how often and how severe breathlessness is when obese ICU patients try to breathe on their own during ventilator weaning.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, Paris · NCT06867354

• Shortness of breath in autoimmune myasthenia gravis: causes and testing

  We will see if patient-reported symptoms and specific clinical tests can identify the causes of shortness of breath in adults with autoimmune myasthenia gravis.

  Recruiting Institut de Myologie, France · Paris · NCT06866652

• Lung and heart ultrasound for acute breathlessness in older adults

  This project will test whether using bedside lung and heart ultrasound helps doctors quickly find the cause and give the right treatment for sudden breathlessness in people over 65.

  Recruiting University Hospital, Toulouse · Toulouse · NCT06807983

• A brief nurse-delivered program plus a digital app to help with breathlessness in advanced lung cancer

  This trial tests whether a short, nurse-led program plus a digital app can help reduce breathlessness in adults with advanced lung cancer.

  Recruiting Massachusetts General Hospital · Coral Gables, Florida and 1 other locations · NCT06791057

• Pulmonary and cardiovascular rehabilitation program for chronic respiratory and heart conditions

  This study tests a rehabilitation program that combines exercise for people with chronic lung and heart conditions to see if it helps them feel better and improve their daily activities.

  Recruiting University of Campinas, Brazil · Campinas, São Paulo · NCT06772922

• Pulmonary and cardiovascular rehabilitation program for chronic respiratory and heart conditions

  This study tests a rehabilitation program that combines exercise for people with chronic lung and heart conditions to see if it helps them feel better and improve their daily activities.

  Recruiting University of Campinas, Brazil · Campinas, São Paulo · NCT06772922

• Pulmonary and cardiovascular rehabilitation program for chronic respiratory and heart conditions

  This study tests a rehabilitation program that combines exercise for people with chronic lung and heart conditions to see if it helps them feel better and improve their daily activities.

  Recruiting University of Campinas, Brazil · Campinas, São Paulo · NCT06772922

• Using GapCO2 to distinguish congestive versus non-congestive acute dyspnea

  This study tries to see if the difference between arterial and transcutaneous pCO2 (GapCO2) can tell whether adults with sudden shortness of breath in the emergency department have a congestive cause or not.

  Recruiting Assistance Publique - Hôpitaux de Paris · Bobigny · NCT06556797

• Evaluating breathing difficulties using exercise testing and oscillometry

  This study is trying to see if measuring airway resistance during breathing tests can help understand the causes of shortness of breath in people who have been referred for exercise testing.

  Recruiting University of Rochester · Rochester, New York · NCT06554353

• Improving lung capacity with a breathing device called Lung Master

  This study is testing if using a breathing device called Lung Master can help improve lung capacity and breathing in healthy adults aged 19-35 and those 65 and older.

  Recruiting University of Nebraska · Omaha, Nebraska · NCT06524856

• Personalized oxygen therapy for cancer patients with shortness of breath

  This study is testing a new personalized oxygen therapy to see if it helps hospitalized cancer patients with shortness of breath feel better compared to standard care.

  Recruiting Phase 2 M.D. Anderson Cancer Center · Houston, Texas · NCT06336642

• SELF-BREATHE: a self-guided online program to reduce chronic breathlessness in adults

  This study will test whether SELF-BREATHE, a self-guided internet-based support program, can help adults with chronic breathlessness from lung or heart conditions breathe easier and feel less distressed.

  Recruiting King's College Hospital NHS Trust · London · NCT06326957

• Observing symptoms in children with first-onset bronchial asthma

  This study looks at how asthma shows up in kids and teens aged 3 to 18, especially if they have unusual symptoms like a chronic cough, to see if a specific questionnaire can help spot these cases better.

  Recruiting Charles University, Czech Republic · Prague · NCT06201494

• Using 129Xe MRI to study lung and blood conditions

  This study is testing how a special MRI using 129Xe gas can help us understand lung and blood conditions better by looking at healthy people and those with specific lung diseases.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT06038630

• Using tadalafil to relieve shortness of breath in Veterans with COPD and pulmonary hypertension

  This study is testing if tadalafil can help Veterans with COPD and pulmonary hypertension breathe easier and improve their overall health.

  Recruiting at 5 sites Phase 2 VA Office of Research and Development · Aurora, Colorado and 4 other locations · NCT05937854

• Assessing diaphragm function in patients with respiratory diseases

  This study is testing how well the diaphragm works in people with respiratory diseases to see if it affects their breathing difficulties and overall health.

  Recruiting RWTH Aachen University · Aachen, North Rhine-Westphalia · NCT05903001

• Assessing diaphragm function in patients with respiratory diseases

  This study is testing how well the diaphragm works in people with respiratory diseases to see if it affects their breathing difficulties and overall health.

  Recruiting RWTH Aachen University · Aachen, North Rhine-Westphalia · NCT05903001

• Evaluating lung function in individuals with long-term effects of COVID-19

  This study is trying to see how COVID-19 affects lung function in people who have ongoing symptoms, compared to those who didn’t have any symptoms.

  Recruiting Tufts Medical Center · Boston, Massachusetts · NCT05866952

• Using menthol to relieve breathing difficulties in healthy individuals and COPD patients

  This study is testing if inhaling menthol can help relieve breathing difficulties in both healthy people and those with COPD.

  Recruiting KU Leuven · Leuven · NCT05785026

• Point-of-care ultrasound to help diagnose sudden shortness of breath

  This will test whether quick bedside ultrasound used by emergency doctors helps identify the cause of sudden shortness of breath in adults with low oxygen or fast breathing.

  Recruiting at 2 sites Region Skane · Helsingborg, Skåne County and 1 other locations · NCT05782478

• Assessing lung function after pulmonary embolism using advanced imaging techniques

  This study is testing advanced imaging techniques to see how well the lungs are working in people who have had a pulmonary embolism and still have trouble breathing, to help improve their rehabilitation.

  Recruiting University Hospital, Brest · Brest · NCT05103670

• A large biobank for acute and emergency medicine

  This study is collecting health information and samples from patients with sudden illnesses in the Emergency Department to see if it can help improve treatments and predict how patients will do.

  Recruiting University Medical Center Groningen · Groningen · NCT04615065

• Using ultrasound to diagnose acute dyspnea in emergency departments

  This study is testing a new ultrasound tool to see if it can help doctors in emergency rooms better diagnose the causes of sudden breathing problems like heart failure, pneumonia, and lung disease.

  Recruiting at 6 sites Central Hospital, Nancy, France · Châlons-en-Champagne and 6 other locations · NCT03691857

NIH-funded research (12)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Patient-centered risk profiling to tailor breathlessness care

  A study from UCLA aims to use AI to identify why a smoker experiences shortness of breath and tailor care to each person.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11445476

• Understanding how the brain shapes breathing to help people with persistent breathlessness

  Researchers are studying how higher brain regions influence breathing and the feeling of breathlessness in people with conditions like COPD and asthma, with the goal of safer, non-ventilation-impairing treatments.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11417976

• Predicting and continuously monitoring breathlessness with noninvasive signals

  A study to create a machine-learning tool that uses easy-to-measure body signals to predict when patients feel breathless, even if they can’t communicate.

  NIH research University of California Riverside · Riverside, United States · NIH-11366620

• Personalized oxygen and breathing support for cancer-related breathlessness

  This trial compares a respiratory-therapist-led program that tailors oxygen and other breathing supports to help hospitalized patients with advanced cancer who are bothered by breathlessness.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11326219

• How the brain creates ongoing breathlessness

  Researchers are recording brain signals from people who already have implanted epilepsy electrodes to understand how higher brain regions produce ongoing breathlessness in conditions like COPD, asthma, heart or neuromuscular disease.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-11166345

• Brief behavioral support to help breathlessness in advanced lung cancer

  A multi-site study tests a short behavioral program delivered by nurses to help adults with advanced lung cancer feel less breathless and more able to do daily activities.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11130485

• Personalized oxygen therapies for cancer-related breathing difficulties

  This study is looking to help people with advanced cancer who are having trouble breathing by comparing a special program led by respiratory therapists to regular care, to see which one works better at making breathing easier.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11074530

• Improving diagnosis of shortness of breath using AI and clinician collaboration

  This study is looking at how we can use artificial intelligence to help doctors better diagnose sudden breathing problems, making sure patients get the right care when they visit the emergency room.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10909198

• A new method to strengthen breathing muscles and lower blood pressure in adults with obesity

  This study is looking at a quick and easy way to help people with obesity strengthen their breathing muscles, which could lower blood pressure, make it easier to breathe, and improve overall health.

  NIH research Florida State University · Tallahassee, United States · NIH-10890695

• Understanding the brain's role in persistent breathing difficulties

  This study is looking at how different parts of the brain affect breathing and cause ongoing breathlessness, aiming to find new ways to help people with chronic breathing problems feel better by focusing on the brain instead of just the lungs.

  NIH research Feinstein Institute for Medical Research · Manhasset, United States · NIH-10848353

• Identifying factors that predict respiratory failure in patients with breathing difficulties

  This study is looking at how certain body signs can help doctors figure out which patients with breathing difficulties, especially those with COVID-19, might be at risk of serious breathing problems before they need a ventilator, so they can get help sooner.

  NIH research University of California, San Diego · La Jolla, United States · NIH-10843751

• Using machine learning to improve treatment for patients with shortness of breath

  This study is exploring a new way to help doctors treat patients who are having trouble breathing by using smart technology to find out which treatments work best for them in real-time.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10458527

Related topics

Quick answers

How many Dyspnea clinical trials are recruiting right now?

36, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 16 countries. The most sites are in United States (9 trials), France (8 trials), Brazil (3 trials), Belgium (2 trials), Switzerland (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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