Targeting Pneumocystis cell-wall enzyme to help people with AIDS-related pneumonia

Who could benefit from this research

What this research studies

This project focuses on how Pneumocystis pneumonia builds its protective cell wall and whether a small molecule can disrupt a key enzyme involved in wall synthesis. By understanding the role of phosphoglucomutase in the organism’s growth and infection, researchers may identify new ways to stop the fungus from thriving in the lungs. The work uses models that show Pneumocystis PGM’s function and tests a selective inhibitor that spares human enzymes. If successful, the findings could point to a targeted approach for treating AIDS-related pneumonia. The team is based at Mayo Clinic Rochester and plans a 2026–2028 funding period through an R21 grant.

Why it matters

Where this research is happening

• Mayo Clinic Rochester
  Rochester, United States Active

Researchers

• Principal investigator: Limper, Andrew H — Mayo Clinic Rochester
• Study coordinator: Limper, Andrew H

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.