Molecular profiling of ARDS, pneumonia, and sepsis in adults using advanced sequencing
Official title: Molecular Phenotyping of ARDS, Pneumonia, and Sepsis using Latent Class Analysis and Metagenomic Sequencing
Funded at University of California, San Francisco · NIH-11321604 · Data updated 2026-11-12
A research team at four California hospitals will study adults with ARDS, pneumonia, or sepsis to identify molecular patterns in their illness using genetic sequencing.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $694,737 |
| NIH project number | 5U01HL168415-04 |
| Project ID | NIH-11321604 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults (21 years and older) with ARDS, pneumonia, or sepsis who are receiving care at the participating California Clinical Center sites.
✕Less likely to help
Patients who do not fit the study’s criteria or who are lost to follow-up may not benefit from the findings.
What this research studies
This project brings together UCSF, UCSF Fresno, Zuckerberg San Francisco General, and Stanford to enroll about 1,000 adults with ARDS, pneumonia, or sepsis into a long-term observational study. Participants will provide clinical data and biospecimens, which will be analyzed to find molecular phenotypes and how they relate to outcomes over 3, 6, and 12 months. The study builds on the team’s experience with phenotyping ARDS and applying metagenomic sequencing to pneumonia and sepsis, aiming to improve understanding of distinct biological subtypes. Results could help tailor future treatments and follow-up care for critically ill patients.
Why it matters
Potential benefit: This work could lead to more precise classification of severe respiratory infections, enabling personalized management and better long-term follow-up for patients.
How similar studies have gone: Prior work by the team has demonstrated molecular phenotypes in ARDS and the use of metagenomic sequencing in pneumonia and sepsis, with ongoing implications for patient care.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Calfee, Carolyn — University of California, San Francisco
- Study coordinator: Calfee, Carolyn
Related research
Other NIH-funded projects on the same topics.
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Coordinating ARDS, Pneumonia, and Sepsis research to improve care
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Understanding ARDS, pneumonia, and sepsis: a big study to map how illness and recovery unfold
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Coordination and data sharing for ARDS, pneumonia, and sepsis research
A national collaborative effort to improve how researchers study ARDS, pneumonia, and sepsis by coordinating centers, data collection, and analyses.
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Investigating the molecular characteristics of ARDS, pneumonia, and sepsis
This study is looking at the differences in the biology of people with Acute Respiratory Distress Syndrome (ARDS), pneumonia, and sepsis to better understand how these conditions affect recovery, and it's inviting 1,000 participants from California to help by sharing their health information and samples over the next y
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Improving care for patients with ARDS, pneumonia, and sepsis
This study is all about improving care for people with serious lung issues like ARDS, pneumonia, and sepsis by gathering and analyzing data from a diverse group of patients, so we can better understand these conditions and find the best treatments for everyone.
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Understanding the recovery patterns of patients with ARDS, pneumonia, and sepsis
This study is looking for people who have had serious breathing problems, like ARDS, pneumonia, or sepsis, to learn more about their recovery and find ways to better predict and improve their health outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.