Reducing unnecessary antibiotic use in children with respiratory infections
Reducing Overuse of Antibiotics With Decision Support in Lower Respiratory Tract Infections
This study is testing whether using a new support system in hospitals can help reduce unnecessary antibiotic prescriptions for kids with respiratory infections like pneumonia and bronchiolitis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 2800 (estimated) |
| Ages | 6 Months to 17 Years |
| Sex | All |
| Sponsor | Vanderbilt University Medical Center Academic / other |
| Locations | 3 sites (Oakland, California and 2 other locations) |
| Trial ID | NCT06788093 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to eliminate inappropriate antibiotic use in pediatric lower respiratory tract infections (LRTIs) by implementing hospital-based clinical decision support systems (CDS) in emergency departments and during hospital transitions. The study will evaluate the effectiveness of these interventions compared to usual care at three U.S. children's hospitals. Participants will be randomly assigned to receive either the CDS interventions or standard care, with the goal of reducing antibiotic prescriptions and improving clinical outcomes for children with conditions like pneumonia and bronchiolitis. The trial will also assess the implementation and process outcomes throughout the study period.
Who should consider this trial
Good fit: Ideal candidates for this study are children presenting with symptoms of lower respiratory tract infections who are either seen in the emergency department or admitted to the hospital.
Not a fit: Patients who do not present with respiratory symptoms or those who are discharged from the hospital without admission will not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce unnecessary antibiotic prescriptions in children, minimizing adverse effects and combating antibiotic resistance.
How similar studies have performed: Previous studies have shown that hospital-based antimicrobial stewardship programs can effectively reduce inappropriate antibiotic use, suggesting that this approach may also be successful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. ED encounter or admission to an inpatient hospital team. 2. EHR-based positive screen for suspected LRTI, defined as a qualifying chief complaint (e.g., cough, shortness of breath, etc.), plus triage documentation of abnormal respiratory effort and/or cough. Exclusion Criteria: None
Where this trial is running
Oakland, California and 2 other locations
- Benioff Children's Hospital - Oakland — Oakland, California, United States (Not_yet_recruiting)
- Benioff Children's Hospital - San Francisco — San Francisco, California, United States (Not_yet_recruiting)
- Monroe Carell Jr Children's Hospital at Vanderbilt — Nashville, Tennessee, United States (Recruiting)
Study contacts
- Principal investigator: Derek J Williams, MD, MPH — Vanderbilt University Medical Center
- Study coordinator: Justine Stassun, MS
- Email: justine.c.stassun@vumc.org
- Phone: 615-936-7276
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.