Host-targeted therapy to prevent lung injury from pneumonia-caused sepsis
Official title: Inflammatory Organ Injury after Pneumonia-Derived Sepsis
Funded at Louisiana State Univ A&m Col Baton Rouge · NIH-11332285 · Data updated 2026-11-12
A patient-focused look at how boosting the body’s own defenses in the lungs could lessen lung and organ damage during severe pneumonia linked to sepsis from bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ A&m Col Baton Rouge NIH-funded |
| Lab location | 1 site (Baton Rouge, United States) |
| Project start | July 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $715,216 |
| NIH project number | 5R01AI180123-03 |
| Project ID | NIH-11332285 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with severe pneumonia and sepsis, particularly those at risk for acute lung injury and ARDS.
✕Less likely to help
Patients without pneumonia-derived sepsis or ARDS may not directly benefit from this specific line of investigation.
What this research studies
This project aims to understand how activating a protective pathway in the lungs helps the body fight a dangerous bacterial infection and reduce ARDS-related injury. Researchers plan to study how the immune system’s responses interact with pneumonia-causing bacteria and how this affects lung health, with an emphasis on the Nrf2 pathway. The work will explore potential host-targeted strategies that could complement antibiotics to prevent organ injury in patients with CRKP-related pneumonia. If successful, these findings could inform new treatment approaches to lower mortality and long-term complications from severe lung infections.
Why it matters
Potential benefit: If successful, the research could lead to host-directed therapies that reduce lung injury and improve survival for patients with pneumonia-related sepsis and ARDS.
How similar studies have gone: Previous work has shown that immune pathways can influence lung injury in infections, but translating this to targeted host therapies remains investigational.
Where this research is happening
-
Louisiana State Univ A&m Col Baton Rouge
Baton Rouge, United States Active
Researchers
- Principal investigator: Jeyaseelan, Samithamby — Louisiana State Univ A&m Col Baton Rouge
- Study coordinator: Jeyaseelan, Samithamby
Related research
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Understanding ARDS, pneumonia, and sepsis: a big study to map how illness and recovery unfold
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Molecular profiling of ARDS, pneumonia, and sepsis in adults using advanced sequencing
A research team at four California hospitals will study adults with ARDS, pneumonia, or sepsis to identify molecular patterns in their illness using genetic sequencing.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.