Condition

Smoking Cessation clinical trials and research

• 90Clinical trials
• 142NIH research projects
• 2New in 30 days
• 17Countries

Newest Smoking Cessation clinical trials

All recruiting trials (90)

• Smoky Futures: Danish Adolescent Nicotine Use over Time

  This observational cohort follows Danish youths ages 15–25 to see how cigarette, e-cigarette, and other nicotine use begin, change, and affect health and education over several years.

  Recruiting University of Southern Denmark · Copenhagen · NCT07910331

• Nicotine Orodispersible Tablet to Relieve Cravings in Smokers

  A nicotine mint orodispersible tablet is tested vs placebo to see if it quickly eases the urge to smoke in adult cigarette smokers.

  Recruiting Phase 2 Kenvue Brands LLC · Mississauga, Ontario · NCT07893158

• Optimizing when weekly chatbot reminders go out to people using a chatbot for quitting smoking

  This study tests whether sending weekly reminders at different times helps people stay engaged with a chatbot smoking-cessation service.

  Recruiting The University of Hong Kong · Hong Kong · NCT07826884

• NMDA and Sigma-1 combination therapy for smoking cessation with AXS-05

  This phase 3 trial tests whether AXS-05 can help adults quit smoking better than placebo or bupropion.

  Recruiting at 28 sites Phase 3 Axsome Therapeutics, Inc. · Phoenix, Arizona and 27 other locations · NCT07766655

• AI-assisted interactive case-based training to improve smoking cessation counseling by medical interns

  This study tests whether AI-powered interactive case-based training helps medical interns provide better smoking cessation counseling.

  Recruiting Assiut University · Asyut, Assuit · NCT07650721

• Tirzepatide for Smoking Cessation in people who smoke and are overweight or obese

  This study tests whether tirzepatide can help adults who smoke quit and manage weight better than placebo when combined with usual smoking-cessation support.

  Recruiting at 4 sites Phase 2 University of Southern California · Los Angeles, California and 3 other locations · NCT07602699

• Multilevel program to increase LDCT lung cancer screening and help African American smokers quit

  This program will try combining low-dose CT screening with culturally tailored smoking-cessation support to help African American smokers who are eligible for LDCT quit and get screened.

  Recruiting at 2 sites Louisiana State University Health Sciences Center in New Orleans · New Orleans, Louisiana and 1 other locations · NCT07576595

• Communal coping in couples where both partners smoke during a quit attempt

  This project tests whether couples who tackle quitting as a team (communal coping) fare better when one partner in a smoking couple tries to quit.

  Recruiting University of Colorado, Denver · Denver, Colorado · NCT07553962

• Proactive pharmacist e-consults to optimize lung health for people with HIV

  This trial tests whether proactive pharmacist-led e-consults can help people with HIV improve lung-health medications, vaccinations, smoking cessation, and deprescribing of certain inhaled medicines or PPIs.

  Recruiting Seattle Institute for Biomedical and Clinical Research · Boise, Idaho and 2 other locations · NCT07507435

• Feasibility of a perinatal smoking and cannabis cessation program

  This study tests a perinatal program to help pregnant people quit tobacco and cannabis and stay smoke-free after birth.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07489443

• Vagal nerve stimulation plus nicotine replacement for quitting smoking

  This study tests whether adding a non-invasive vagal nerve stimulator to nicotine patches helps adults quit smoking.

  Recruiting Phase 2/3 Mayo Clinic · Rochester, Minnesota · NCT07487818

• Mindfulness Relapse Prevention for Smoking and Alcohol in Cancer Survivors

  This study tests whether Mindfulness-Based Relapse Prevention for Smoking and Alcohol (MBRP-SA) helps cancer survivors quit smoking and reduce risky drinking compared with standard care.

  Recruiting H. Lee Moffitt Cancer Center and Research Institute · Tampa, Florida · NCT07447635

• Group Acceptance and Commitment Therapy to reduce smoking and change brain connectivity in people with schizophrenia

  This trial tests whether group Acceptance and Commitment Therapy helps people with schizophrenia who smoke to quit and changes brain responses to tobacco cues.

  Recruiting at 5 sites The Hong Kong Polytechnic University · Hong Kong and 4 other locations · NCT07441928

• Text messages plus small incentives to help pregnant women quit smoking

  This project will test whether supportive text messages plus small financial incentives help pregnant women on Medicaid or WIC quit smoking better than text messages alone.

  Recruiting University of Kansas Medical Center · Kansas City, Kansas · NCT07420621

• A program to help Black adults quit smoking

  This trial tests three different, culturally tailored smoking-cessation approaches to see which helps Black adults quit smoking over 26 weeks.

  Recruiting Phase 4 University of Wisconsin, Madison · Phoenix, Arizona and 4 other locations · NCT07419425

• Combining smoking-cessation support with low-dose CT lung screening

  This project tries to see if combining low-dose CT scans with smoking-cessation support (a smartphone app or written materials) helps people aged 50–74 who still smoke quit and find lung cancer earlier.

  Recruiting Oulu University Hospital · Helsinki and 4 other locations · NCT07331519

• Chatbot to help quitting smoking in Black adults in Minnesota

  This study tests whether a smoking-cessation chatbot is acceptable and helpful for Black adults trying to quit smoking in Minnesota.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07301151

• Telegram-based smoking-cessation support after heart attack

  This trial tests whether a 6-month Telegram chatbot program helps people who had a heart attack quit smoking more often than standard care alone.

  Recruiting ITMO University · Ulyanovsk, Ulyanovsk Oblast and 1 other locations · NCT07230249

• Mindfulness smartphone program plus counseling and nicotine replacement to help cancer survivors quit smoking

  This project will try a mindfulness smartphone app together with brief face-to-face counseling and nicotine replacement to help cancer survivors who smoke quit.

  Recruiting Rutgers, The State University of New Jersey · New Brunswick, New Jersey · NCT07210567

• Personalized treatment to help people with cancer quit smoking and live longer

  We will test whether personalized tobacco treatment using clinical, genetic, and biomarker information helps cancer patients who smoke quit and use cessation medications more than usual care.

  Recruiting at 2 sites Washington University School of Medicine · St Louis, Missouri and 1 other locations · NCT07166120

• Varenicline plus enhanced TMS to help adults quit smoking and vaping

  This study tests whether adding active enhanced accelerated transcranial magnetic stimulation (aTMS) to varenicline helps adults 18–65 quit nicotine use more effectively than varenicline with sham stimulation.

  Recruiting Phase 4 Massachusetts General Hospital · Boston, Massachusetts · NCT07145866

• Trauma-informed smoking cessation support during pregnancy

  This project will test a trauma-informed smoking cessation program that combines the 4Rs with the 5As to help pregnant women who smoke and have histories of trauma.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07129590

• CONNECT Multilingual: Helping Spanish and Cantonese Speakers Quit Smoking During Lung Cancer Screening

  This trial tests a multilingual version of the CONNECT program to help current adult smokers who speak Spanish or Cantonese quit smoking while undergoing lung cancer screening.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07111936

• Varenicline with Nicotine Lozenges and a Smartphone App to Help You Stay on Track

  A 2x2 trial tests whether adding nicotine lozenges and a smartphone adherence app to varenicline helps people quit smoking more than varenicline alone.

  Recruiting Phase 2 University of Oklahoma · Oklahoma City, Oklahoma · NCT07099638

• Cigarette smoking effects on leg movement speed and coordination in young adults

  We will see if daily cigarette smoking changes leg coordination and 30-meter sprint speed in healthy 18-25-year-olds.

  Recruiting Saglik Bilimleri Universitesi · Istanbul, Üsküdar · NCT07075068

• Smoking's effect on lower-limb speed and coordination in young adults.

  We will test whether young adults who smoke have slower or less coordinated leg movements compared with non-smokers.

  Recruiting Saglik Bilimleri Universitesi · Istanbul, Üsküdar · NCT07061522

• Smokefree Family Living to help Chinese American households quit smoking and reduce third‑hand smoke

  This trial tests whether a tailored Smokefree Family Living program helps Chinese American smokers and their household members quit smoking and lower third‑hand smoke contamination in their homes.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07049757

• Mindfulness smoking cessation for Northern Plains Tribal women affected by intimate partner violence

  This program will try a culturally tailored, trauma-informed mindfulness approach to help Northern Plains Tribal women who smoke and have experienced intimate partner violence quit smoking.

  Recruiting National Heart, Lung, and Blood Institute (NHLBI) · Rapid City, South Dakota · NCT07013968

• Counseling for smoking cessation among healthcare professionals

  This study tests if counseling at work can help healthcare professionals who smoke quit by measuring their carbon monoxide levels.

  Recruiting Groupe Hospitalier Mutualiste de Grenoble · Grenoble, isere · NCT06988644

• Evaluating smoking cessation using e-cigarettes and nicotine therapy

  This study is testing whether using e-cigarettes or nicotine replacement therapy can help people with obesity who smoke quit smoking and manage their weight better.

  Recruiting Brown University · Providence, Rhode Island · NCT06948058

• ACT Lung Health Program to help Chinese and Korean American smokers quit

  This trial tests a counseling and educational program to help Chinese and Korean American smokers at high risk for lung cancer quit smoking.

  Recruiting at 2 sites Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT06945120

• Smoking cessation program in Hong Kong workplaces

  This study is testing a smoking cessation program in Hong Kong workplaces to see if a mix of mobile support, health talks, counseling, and nicotine replacement can help employees quit smoking.

  Recruiting The University of Hong Kong · Hong Kong · NCT06932718

• Education program for quitting smoking

  This study is testing an education program to help people with mental health disorders who smoke to quit by providing support from nurses.

  Recruiting Erzurum Technical University · Erzurum, Erzurum · NCT06930547

• Actívatexto: Helping Latinos quit smoking and become more active

  This trial tests whether Actívatexto, a text-message program combined with wearables and nicotine replacement, helps Latino adults who smoke quit and increase their physical activity.

  Recruiting University of Rochester · Rochester, New York · NCT06926608

• A program to help people quit smoking using CBT and mindfulness audio support

  This study is testing if combining text messages for quitting smoking with mindfulness audio support helps people stop smoking better than just using text messages alone.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou · NCT06901713

• Cytisine treatment for helping smokers quit and its effects on heart health

  This study tests if a plant-based treatment called cytisine can help adult smokers quit and also looks at how it affects their heart health during and after the treatment.

  Recruiting University of Athens · Athens, Haidari · NCT06885970

• Quitting Matters: a smoking quit program for people living with HIV

  This 6-month program will test whether a tailored smartphone app plus nicotine patches and gum helps people living with HIV quit smoking better than a standard quit app.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT06883097

• Quitting Matters: a smoking quit program for people living with HIV

  This 6-month program will test whether a tailored smartphone app plus nicotine patches and gum helps people living with HIV quit smoking better than a standard quit app.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT06883097

• Tobacco cessation program for community behavioral health sites in Chicago

  This project will test a community-informed smoking cessation program to help adults who smoke and receive services at behavioral health organizations in Chicago.

  Recruiting University of Chicago · Chicago, Illinois · NCT06837220

• Empowering smoking cessation for LGBTQ+ adults in Oklahoma, Arkansas, and Texas

  This project will try adding online volunteer activities and a digital support hub to a quit-app plus mailed nicotine patches to see if it helps LGBTQ+ adults in Oklahoma, Arkansas, and Texas quit smoking.

  Recruiting Phase 2/3 University of Oklahoma · Oklahoma City, Oklahoma · NCT06820034

• tDCS plus varenicline to help people quit smoking

  This will test if adding noninvasive tDCS brain stimulation to varenicline helps adults who smoke at least 8 cigarettes a day quit and stay smoke-free.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06798324

• AI Molar Mind to help people quit smoking with oral health feedback

  This study will test whether AI Molar Mind, a digital tool that reviews your oral health and gives personalized feedback, can help adults who smoke at least five cigarettes a day quit smoking.

  Recruiting Fayoum University · Fayoum, Alexandria Governorate · NCT06762210

• New approaches to help people quit smoking

  This project tests a short, professionally made educational video to help adult smokers (at least 10 cigarettes per day) — especially Black and other racial/ethnic groups — understand varenicline and decide whether to try medication or quit smoking.

  Recruiting University of Chicago · Chicago, Illinois · NCT06751927

• Technology-based motivational interviewing to help adults quit smoking

  This project will try a chatbot-based motivational interviewing coach to help adult primary care patients who smoke become ready to quit and create a personalized quit plan.

  Recruiting at 2 sites University of California, San Francisco · San Francisco, California and 1 other locations · NCT06713603

• Using an air quality monitor to encourage smoke-free homes for cancer patients

  This study is testing if using an air quality monitor can help cancer patients who smoke create smoke-free homes and quit smoking.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT06693700

• Evaluating nicotine pouches for quitting smoking

  This study is testing if tobacco-free nicotine pouches can help smokers switch from cigarettes by trying out different nicotine levels over 28 days.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06678789

• Testing a smartphone app to help nondaily smokers quit smoking

  This study tests a new smartphone app designed to help people who smoke occasionally quit smoking and see if it works better than an existing app.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06678243

• A mobile game to help young people quit smoking

  This study tests a smartphone game designed to help young people aged 16-25 quit smoking by using fun strategies and support over five weeks.

  Recruiting Behavioural Science Institute · Nijmegen, Gelderland · NCT06675526

• Adapting a Skills-Based Smoking Cessation Program for Gender-Diverse Adults Under Stress

  A skills-based smoking cessation program is being adapted and tested to see if it helps gender-diverse adults who smoke, especially when stressed by gender-related factors and mood problems.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts and 2 other locations · NCT06654414

• Smoking cessation for parents with health navigator support to tackle social needs

  We’re testing a program that helps parents quit smoking and also addresses their social challenges to reduce kids’ exposure to secondhand smoke.

  Recruiting at 3 sites St. Justine's Hospital · Montreal, Quebec and 2 other locations · NCT06651684

• Effects of Cytisinicline on Smoking Cues in Daily Smokers

  This study tests if a medication called cytisinicline can help daily smokers reduce their cravings and reactions to cigarette-related triggers.

  Recruiting Phase 2 University of California, Los Angeles · Los Angeles, California · NCT06617312

• Optimizing a smoking cessation program for people living with HIV

  This study is trying to find the best way to help people living with HIV quit smoking by using a mix of support methods like counseling, mentoring, and text reminders.

  Recruiting Phase 4 New York University · New York, New York · NCT06598397

• Investigating nicotine pouches and mini lozenges as alternatives to smoking

  This study is testing if nicotine pouches and mini lozenges can help smokers who aren't ready to quit cigarettes yet by giving them alternatives to try for a week.

  Recruiting Phase 4 University of Wisconsin, Madison · Madison, Wisconsin · NCT06595459

• Rural Smokers Quit: Testing Different Ways to Help People Live Smoke-Free

  This study tests different quit-smoking resources with rural adults to see which methods help them stop smoking.

  Recruiting Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT06584929

• Proactive tobacco treatment for household smokers through pediatric care

  This study is testing a new way to help household smokers quit tobacco by using support from pediatric care to see if it can improve their chances of success.

  Recruiting Children's Hospital of Philadelphia · Philadelphia, Pennsylvania · NCT06582693

• Mobile phone–based smoking-cessation support for parents

  A mobile, AI-powered quitting support program is being tested to help smoking parents see if it helps them quit more than brief advice.

  Recruiting Beijing Normal University · Zhuhai, Guangdong · NCT06570122

• Family-based financial incentives to help Alaska Native families quit smoking

  This study tests whether giving financial rewards to Alaska Native families can help them quit smoking better than those who don’t receive rewards.

  Recruiting Mayo Clinic · Anchorage, Alaska · NCT06556433

• Helping Alaska Native people quit smoking using a personalized approach

  This study is testing a personalized method to help Alaska Native and American Indian people quit smoking by using their body’s response to nicotine to create tailored treatment plans.

  Recruiting Southcentral Foundation · Anchorage, Alaska · NCT06556238

• Culturally aligned digital smoking cessation program for American Indians

  This study is testing a new online program designed to help American Indian people quit smoking by using methods that respect their cultural values.

  Recruiting Masonic Cancer Center, University of Minnesota · Minneapolis, Minnesota · NCT06544811

• Helping dual users of cigarettes and e-cigarettes quit smoking

  This study is testing different ways to help people who smoke both cigarettes and e-cigarettes quit for good by using medications and counseling.

  Recruiting Phase 4 University of Wisconsin, Madison · Madison, Wisconsin · NCT06474299

• Counseling methods for quitting smoking

  This study is testing whether video counseling can help older smokers quit smoking just as well as traditional in-person counseling.

  Recruiting Scientific Institute San Raffaele · Milan, Italy, Milan · NCT06451029

• Pain and Smoking: A Program to Help Veterans Quit Smoking with Chronic Pain

  This study tests whether the PASS2 program, which adds nightly surveys to a pain-and-smoking cessation intervention, helps Veterans with chronic pain quit smoking better than usual care.

  Recruiting VA Office of Research and Development · West Haven, Connecticut · NCT06442514

• Helping patients stop smoking before spine surgery

  This study is testing whether helping patients quit smoking before spine surgery can lead to better recovery and results compared to those who keep smoking or don’t smoke at all.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06361459

• Comparing smoking cessation methods for lung cancer screening patients

  This study tests two different ways to help people quit smoking who are getting screened for lung cancer to see which method works better.

  Recruiting Phase 3 Georgetown University · Washington D.C., District of Columbia · NCT06290869

• A project to help parents quit smoking and protect children from secondhand smoke

  This study is testing a new program to help parents who smoke quit for good, so they can protect their kids from secondhand smoke.

  Recruiting The University of Hong Kong · Hong Kong · NCT06127589

• Quitxt bilingual text-and-chat program to help young Latino adults quit smoking

  This test tries to see if Quitxt, a bilingual, culturally tailored text-message and chat program, helps Latino young adults (ages 18–29) quit smoking compared with abbreviated texts and a referral to Yes Quit.

  Recruiting The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT05958667

• Helping Veterans quit smoking with social support

  This study is testing whether getting support from friends or family can help Veterans quit smoking more successfully than going it alone.

  Recruiting VA Office of Research and Development · Minneapolis, Minnesota · NCT05868421

• Personalized treatment for smoking cessation in primary care

  This study is testing a personalized approach to help people quit smoking in primary care to see if it works better than the usual methods.

  Recruiting Washington University School of Medicine · St Louis, Missouri · NCT05846841

• Improving smoking cessation and HIV/TB treatment outcomes in South Africa

  This study is testing a new program to help people living with HIV and tuberculosis in Cape Town quit smoking to improve their overall health and treatment results.

  Recruiting Massachusetts General Hospital · Rondebosch · NCT05842161

• A program to help rural smokers who aren't ready to quit

  This study is testing a new program to help rural adults who smoke but aren't ready to quit by providing them with support and resources through mobile health technology and community paramedics.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT05790486

• Helping people with HIV quit smoking in India

  This study is testing if a combination of a smoking cessation medication and a mobile support program can help people with HIV in India quit smoking more effectively than standard care.

  Recruiting at 2 sites Phase 3 University of Colorado, Denver · Aurora, Colorado and 1 other locations · NCT05786547

• Evaluating an online program for quitting smoking in rural areas

  This study is testing an online program to help people in rural areas quit smoking and comparing it to regular care to see which works better.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05764759

• Helping Cambodian people with HIV quit smoking using text messages

  This study is testing if sending text messages can help people in Cambodia who have HIV quit smoking by providing support and resources.

  Recruiting at 3 sites H. Lee Moffitt Cancer Center and Research Institute · Phnom Penh and 2 other locations · NCT05746442

• Helping hospitalized heart patients quit smoking

  This study is testing if giving financial rewards along with nicotine replacement therapy can help heart patients in the hospital quit smoking for good.

  Recruiting University of Vermont Medical Center · Burlington, Vermont · NCT05738408

• Nurse practitioner-led program to help hospitalized smokers quit

  This study tests a program led by nurse practitioners to help hospitalized smokers with heart and lung issues quit smoking by using better medications and support.

  Recruiting Phase 2 Baystate Medical Center · Springfield, Massachusetts · NCT05733767

• Improving smoking cessation in the African American community with extended bupropion treatment

  This study is testing if longer treatment with bupropion can help African American daily smokers quit smoking better than the usual shorter treatment, along with personalized counseling.

  Recruiting Phase 3 University of Kansas Medical Center · Kansas City, Missouri · NCT05732272

• Program to help cancer survivors improve health behaviors

  This study is testing a new program to help cancer survivors improve their health habits, like losing weight and being more active, to see if it works better than regular care.

  Recruiting Northwestern University · Chicago, Illinois · NCT05687604

• Using community pharmacists to help rural smokers quit

  This study is testing a new program where pharmacists help rural smokers in Appalachia quit smoking by providing medication and support, like texting and quitline resources.

  Recruiting University of Virginia · Charlottesville, Virginia · NCT05660525

• Screening for bladder cancer using urine tests

  This study is testing if regular urine tests every six months can help catch bladder cancer earlier in people over 50 who are at high risk.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT05646485

• Phone-based support for quitting smoking in Lebanon

  This study is testing different ways to help people in Lebanon quit smoking, including phone support and nicotine patches, to see which method works best.

  Recruiting University of Florida · Beirut · NCT05628389

• Evaluating music therapy and nicotine replacement for smoking cessation in students

  This study is testing if combining music therapy with nicotine replacement can help college students quit smoking better than using nicotine replacement alone.

  Recruiting Poitiers University Hospital · Poitiers · NCT05589220

• Impact of Menstrual Cycle Phase on Smoking Cessation

  This study tests if starting smoking cessation treatment during certain phases of the menstrual cycle helps women quit smoking more successfully.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT05515354

• Helping smokers practice quitting tobacco

  This study is testing a new way to help smokers practice quitting tobacco by trying short breaks from smoking without pressure, comparing it to regular counseling, to see which method helps them make more quit attempts over six months.

  Recruiting Phase 1/2 Rush University Medical Center · Chicago, Illinois · NCT05513872

• Improving smoking cessation through telehealth in primary care

  This study is testing if an online visit can help people quit smoking better than regular care by offering support and possibly medication.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT05493254

• Optimizing smoking cessation treatments for people with HIV in South Africa

  This study is testing a new way to help people with HIV in South Africa quit smoking by using a combination of counseling, support from peers, and medications to see if it works better than what’s currently available.

  Recruiting Phase 2/3 Johns Hopkins University · Soweto, Gauteng · NCT05413122

• Using brain stimulation to help people with schizophrenia quit smoking

  This study tests whether a type of brain stimulation can help people with schizophrenia quit smoking by comparing two different methods.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT05276050

• A smartphone app designed to help African American smokers quit smoking

  This study is testing a smartphone app designed to help African American smokers quit smoking by providing support and rewards during their quit journey.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma · NCT05188287

• Preventing postpartum smoking relapse with hormone treatment

  This study is testing if progesterone can help new and expecting moms who smoke stay smoke-free after giving birth.

  Recruiting Phase 4 University of Minnesota · Minneapolis, Minnesota · NCT04783857

• Personalized wellness intervention for smoking cessation in adults living with HIV

  This study tests a personalized program to help adults with HIV quit smoking and see if it works better than standard methods.

  Recruiting at 2 sites University of Arizona · Phoenix, Arizona and 1 other locations · NCT04725617

• Collecting biological samples from individuals with and without lung disease

  This study is collecting blood, urine, and airway samples from both healthy people and those with lung diseases to see how their biology differs and learn more about these conditions.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT01776398

NIH-funded research (newest 40 of 142)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Social stress and smoking: why disadvantaged young adults struggle to quit

  This grant looks at how daily social stress affects if and when disadvantaged young adults who smoke can quit and stay quit.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11540695

• I-STOP: a mobile health program to help people with HIV quit smoking

  A smartphone-based program designed to help people with HIV quit smoking in a sustainable, affordable way.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11535367

• Smoking cessation help for people with HIV in South Africa

  A program is being tested to help people living with HIV in South Africa quit smoking in ways that fit low-resource clinics and show good value.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11535332

• Mobile tools to understand how sleep affects quitting smoking

  This project uses a smartphone to track sleep and smoking in lower-income adults trying to quit to find how sleep patterns relate to staying smoke-free.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11502972

• Integrated approach to lung screening and quitting for African Americans

  A multi-level program aims to boost LDCT lung cancer screening uptake and help African American smokers quit, with support from a comprehensive community-focused plan.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11491488

• Peer-led smoking-cessation program for public housing residents

  A peer-led program with eight group sessions plus nicotine replacement therapy is tested on adults living in public housing to help them quit smoking.

  NIH research George Washington University · Washington, United States · NIH-11449312

• Real-world use of quit aids in US adults

  This project studies how well different quitting aids work in everyday life for adults in the United States who smoke.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11447909

• Very low nicotine cigarettes to help quitting for people with chronic back pain

  A study will test whether switching to very low nicotine cigarettes helps people with chronic back pain quit smoking and feel less pain.

  NIH research Duke University · Durham, United States · NIH-11430727

• Exercise-based quitting aid for adults with high anxiety sensitivity

  A program tests whether a structured, high‑intensity exercise plan helps adults with high anxiety sensitivity quit smoking and feel better mentally.

  NIH research University of Texas at Austin · Austin, United States · NIH-11419742

• Smoking cessation support for people with HIV in South Africa

  A Johns Hopkins-led effort tests practical, proven smoking-cessation approaches with people living with HIV in South Africa to see if they work well in that setting and are worth expanding.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11419226

• Sustainable mobile health support to help people with HIV quit smoking

  Researchers are testing a scalable smartphone-based program to help people with HIV quit smoking in real-world care settings.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11411242

• A new, phone-based olfactory aid to help adults quit smoking

  A smartphone-based program will combine a guided olfactory cue with a popular quit-smoking app to help adults reduce cravings and support cessation.

  NIH research University of Houston · Houston, United States · NIH-11404970

• Actify: a mobile tool to help people quit smoking by managing mood

  A mobile app called Actify! helps people quit smoking by addressing depressive mood as part of the quit plan.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11400405

• Mobile health program to help people with HIV in Laos quit smoking

  This project offers a smartphone app plus clinic outreach to help people living with HIV in Laos quit smoking.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11400256

• Digital craving-regulation training to help adults quit smoking

  A brief, online program teaches adults how to manage cigarette craving to improve quitting with or without medication.

  NIH research University of California Berkeley · Berkeley, United States · NIH-11399806

• Proactive smoking-cessation support in primary care via an automated e-visit

  A researcher team at a medical center is testing an electronic, auto-delivered quit-smoking visit in primary care to help adult smokers use evidence-based treatments.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11399022

• Harm-reduction sampling to help people not ready to quit smoking

  A practical approach tests whether giving people who aren’t ready to quit access to harm-reduction smoking aids can help them move toward quitting.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11397774

• Transforming smoking cessation care in cancer treatment

  A cancer center project helps doctors reliably help patients quit smoking during cancer care using electronic health records and proven quitting strategies.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11397545

• Culturally tailored smoking-cessation resources for American Indian people

  A randomized study tests culturally tailored digital smoking-cessation tools designed for American Indian individuals to help them quit smoking.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11395454

• Digital and Hormonal Biomarkers to Personalize Smoking Cessation for Women of Reproductive Age

  A study aims to use hormonal and digital biomarkers to tailor smoking cessation therapies for women in their reproductive years.

  NIH research Arkansas Children's Hospital Res Inst · Little Rock, United States · NIH-11390189

• Targeting Reinforcement to Help Smokers with Opioid Use Disorder and Chronic Pain Quit

  A study to see if switching people who smoke and are on buprenorphine for opioid use disorder and chronic pain to cigarettes with very low nicotine can help them quit smoking.

  NIH research Duke University · Durham, United States · NIH-11384704

• AI-powered quitting coach for Alaska Native adults

  A smartphone chatbot using artificial intelligence to help Alaska Native adults quit smoking, delivered without in-person visits.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11382971

• Activatexto: help Latinos quit smoking and get more activity

  A Latino-focused program uses text messages to help adults quit smoking and become more physically active.

  NIH research University of Rochester · Rochester, United States · NIH-11382025

• Smartphone app helps nondaily smokers quit

  A smartphone app called Smiling Instead of Smoking (SiS) is being tested to help adults who smoke non-daily to quit for good.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11381209

• Quit-smoking support for adults with HIV or TB in South Africa

  This project will create and try smoking-cessation support for adults with HIV or TB in South Africa to help them quit and stay on treatment.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11379030

• Proactive smoking cessation in rural primary care using an electronic visit

  A rural-focused program will use an automated electronic visit in primary care to help smokers quit, reaching patients through their usual clinicians.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11378255

• Smoking cessation support for people living with HIV in South Africa

  Seeing if proven quit-smoking programs can help adults with HIV in South Africa stop smoking and lower their risk of TB, heart, and lung disease.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11376842

• GLP-1/GIP receptor activating therapy to help adults quit smoking and lose weight

  A large study will test a GLP-1/GIP receptor agonist to help adults with atherosclerotic cardiovascular disease quit smoking and manage weight.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11373082

• ASSIST: How Medicaid policies on quitting smoking before surgery affect outcomes

  A study on how requiring Medicaid patients to quit smoking before elective surgery influences postoperative outcomes and access to care.

  NIH research Oregon Health & Science University · Portland, United States · NIH-11369247

• Culturally tailored mobile smoking cessation and mental health support for Black adults with HIV

  A mobile health program designed for Black adults living with HIV to help quit smoking and improve mental health in a way that respects culture and personal experiences.

  NIH research University of Houston · Houston, United States · NIH-11362609

• Adaptive treatment for early smoking relapse in adults

  This study tests different paths to help adults who smoke quit again after an early relapse, including trying a different quitting medicine or switching to a safer nicotine product.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11362332

• Smoking cessation program for Veterans with chronic pain using interactive voice/phone support

  A randomized trial tests whether an integrated pain-and-smoking cessation program delivered to Veterans with chronic pain helps people quit smoking better than standard quitting methods.

  NIH research VA Connecticut Healthcare System · West Haven, United States · NIH-11360812

• A smarter, cost-effective smoking cessation package for people with HIV in clinical care

  A study will test a combination of support methods to help people living with HIV quit smoking more effectively in real clinical settings.

  NIH research New York University · New York, United States · NIH-11353883

• Community pharmacists helping rural Appalachia quit smoking

  A real-world study tests using local pharmacists to deliver a Medicaid-style medication-management approach to help rural smokers in Appalachia quit and stay quit.

  NIH research University of Virginia · Charlottesville, United States · NIH-11330162

• Proud to Quit (P2Q): a mobile, person-centered program to help transgender adults quit smoking

  This project offers a mobile, person-centered program to help transgender adults quit smoking and support access to gender-affirming care.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11325688

• Medications and support to help hospitalized heart and lung patients quit smoking

  This project uses tailored quit-smoking medicines, nurse counseling, and supportive text messages to help hospitalized adults with heart or lung disease stop smoking.

  NIH research Baystate Medical Center, INC. · Springfield, United States · NIH-11314529

• How using both cigarettes and e-cigarettes affects quitting smoking

  This project follows adults who both smoke cigarettes and use e-cigarettes to learn how their day-to-day use patterns connect to quitting combustible cigarettes.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11312643

• Water Inhalable Nicotine: a new cartridge-based nicotine replacement inhaler

  A new cartridge-based inhaled nicotine replacement therapy called Water Inhalable Nicotine (WIN) aims to help adults quit smoking by delivering nicotine in a controlled, effective way.

  NIH research Scientific Horizons Consulting LLC · Irvine, UNITED STATES · NIH-11311203

• Libre del cigarrillo: Spanish-language mobile tool to help Hispanic smokers quit

  A mobile app in Spanish will extend a proven smoking-cessation program to Hispanic smokers and help them quit.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11310741

• Digital financial-incentives support for quitting smoking during pregnancy

  A digital program uses financial incentives to help pregnant people quit smoking, especially in clinics with limited access to care.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11308970

Related topics

Quick answers

How many Smoking Cessation clinical trials are recruiting right now?

90, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 17 countries. The most sites are in United States (62 trials), Canada (4 trials), Hong Kong (3 trials), Turkey (Türkiye) (3 trials), China (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 8, Phase 2: 5, Phase 3: 4, Phase 2/3: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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