Condition

Tobacco Smoking clinical trials and research

• 18Clinical trials
• 4NIH research projects
• 5Countries

Newest Tobacco Smoking clinical trials

All recruiting trials (18)

• Two Telehealth Interventions to Help Smokers with Chronic Pain

  Two telehealth programs will be tested to see if they’re doable and acceptable for adults who smoke and have chronic pain.

  Recruiting Binghamton University · Binghamton, New York · NCT07743710

• Proactive Automatized Lifestyle Intervention for Multiple Health Risk Behaviors

  This trial tests a proactive, automated program to help hospital patients reduce tobacco and alcohol use, eat better, and exercise more.

  Recruiting University Medicine Greifswald · Greifswald · NCT07441603

• How price, availability, and cues influence marijuana and cigarette use in young adults

  This project will see if changing price, availability, and exposure to cues changes how 18- to 25-year-olds who smoke both marijuana and tobacco choose between them.

  Recruiting Brown University · Providence, Rhode Island · NCT07398443

• Buteyko breathing plus smoking-hygiene for adolescents with passive household smoke exposure and chronic Eustachian tube dysfunction

  This project will test whether adding regular Buteyko breathing exercises to smoking-hygiene education helps adolescents exposed to household tobacco smoke who have chronic Eustachian tube dysfunction and reduced lung function.

  Recruiting Cairo University · Giza, Dokki · NCT07236580

• Abuse potential of five modern oral nicotine products

  This will test how five modern oral nicotine products compare with cigarettes and nicotine gum in how satisfying they feel and how much nicotine adult smokers absorb.

  Recruiting RAI Services Company · Overland Park, Kansas · NCT07132814

• Trauma-informed smoking cessation support during pregnancy

  This project will test a trauma-informed smoking cessation program that combines the 4Rs with the 5As to help pregnant women who smoke and have histories of trauma.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07129590

• Helping Veterans with chronic disease reduce smoking and risky drinking

  This program will test whether a mailed, tailored education packet plus a brief motivational phone call helps Veterans with diabetes, heart disease, or related risk factors who smoke or drink too much become more motivated to change.

  Recruiting Phase 3 VA Office of Research and Development · Buffalo, New York · NCT07039175

• Cannabidiol (CBD) for reducing stress and nicotine withdrawal in daily cigarette smokers.

  This trial tests whether a single dose of CBD can reduce stress responses and nicotine withdrawal symptoms in adults who smoke cigarettes daily.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT07001930

• Improving tobacco cessation support for patients in poverty in Utah

  This study is testing new ways to help people living in poverty in Utah quit smoking by using support tools and strategies in their healthcare clinics.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06881069

• tDCS plus varenicline to help people quit smoking

  This will test if adding noninvasive tDCS brain stimulation to varenicline helps adults who smoke at least 8 cigarettes a day quit and stay smoke-free.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06798324

• Using an air quality monitor to encourage smoke-free homes for cancer patients

  This study is testing if using an air quality monitor can help cancer patients who smoke create smoke-free homes and quit smoking.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT06693700

• Evaluation of the INSPIRE Respiratory Health Program in Botucatu, Brazil

  This study is testing the INSPIRE program to see how well it helps adults with respiratory issues in Botucatu manage their health and access care over five years.

  Recruiting UPECLIN HC FM Botucatu Unesp · Botucatu, São Paulo · NCT06673225

• Comparing mobile health screening to traditional methods for early detection of oral cancer in rural Varanasi.

  This study tests if using mobile health screenings can help find oral cancer earlier than traditional methods for people living in rural Varanasi.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT06535867

• Using cannabidiol to help reduce cigarette smoking

  This study is testing if taking cannabidiol (CBD) can help people who want to quit smoking cigarettes reduce their tobacco use.

  Recruiting Phase 2 University of California, Los Angeles · North Hollywood, California · NCT06218056

• Smoke-free home initiative for subsidized housing residents

  This study is testing a smoke-free initiative in subsidized housing to see if it helps residents stop smoking and create healthier homes.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06170437

• Impact of Menstrual Cycle Phase on Smoking Cessation

  This study tests if starting smoking cessation treatment during certain phases of the menstrual cycle helps women quit smoking more successfully.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT05515354

• Using Cannabidiol to Help People Quit Smoking

  This study is testing if taking cannabidiol (CBD) can help people who smoke more than 10 cigarettes a day quit smoking and feel better during withdrawal.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT05445804

• Smoking cessation treatment for schizophrenia patients using varenicline

  This study is testing if the smoking cessation drug varenicline can help people with schizophrenia quit smoking while also managing their movement side effects from antipsychotic medications.

  Recruiting Phase 4 Corporal Michael J. Crescenz VA Medical Center · Philadelphia, Pennsylvania · NCT03495024

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding brain changes from smoking in people with HIV

  This research aims to understand how smoking affects the brain chemistry of people living with HIV.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11136986

• How tobacco smoking affects immune function and prognosis in multiple sclerosis

  This study is looking at how smoking affects the immune system and the progression of multiple sclerosis (MS) in people with the condition, to help find better ways to manage MS for those who smoke.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-11050242

• Understanding how tobacco smoking affects the brain in people with HIV

  This study is looking at how smoking and HIV affect the brain's chemistry, using a special imaging technique to see changes in the brain, and it aims to help people with HIV who smoke by finding better ways to get clear images of their brains.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-10894835

• Helping cancer survivors quit smoking and reduce distress through telehealth

  This study is testing a new way to help cancer survivors quit smoking and feel better by using a special brain stimulation treatment they can do at home with support from doctors online.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-10680370

Related topics

Quick answers

How many Tobacco Smoking clinical trials are recruiting right now?

18, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (13 trials), Canada (2 trials), Brazil (1 trial), Egypt (1 trial), Germany (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 3, Phase 1: 2, Phase 2: 1, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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