Testing a smartphone app to help nondaily smokers quit smoking

Randomized Clinical Trial to Test the Efficacy of a Smartphone App for Smoking Cessation for Nondaily Smokers (SiS4)

Not applicable Interventional Massachusetts General Hospital · NCT06678243

This study tests a new smartphone app designed to help people who smoke occasionally quit smoking and see if it works better than an existing app.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment1600 (estimated)
Ages18 Years and up
SexAll
SponsorMassachusetts General Hospital Academic / other
Locations1 site (Boston, Massachusetts)
Trial IDNCT06678243 on ClinicalTrials.gov

What this trial studies

This project aims to evaluate the effectiveness of a new smartphone app, SiS4, designed specifically for individuals who smoke nondaily and wish to quit. The app incorporates positive psychology exercises and proven smoking cessation tools to support users in their quitting journey. Participants will engage with the app daily for seven weeks, completing online surveys to assess changes in their smoking habits, attitudes, and mental well-being. The study will compare the SiS4 app's effectiveness against an existing app, QuitGuide, to determine which is more beneficial for nondaily smokers.

Who should consider this trial

Good fit: Ideal candidates for this study are adults aged 18 and older who smoke less than daily but at least weekly and have a current intention to quit.

Not a fit: Patients who smoke daily or do not intend to quit smoking may not receive any benefit from this study.

Why it matters

Potential benefit: If successful, this app could provide a tailored and effective tool for nondaily smokers to successfully quit smoking.

How similar studies have performed: Previous studies have shown promise in using mobile health interventions for smoking cessation, indicating that this approach may be effective for nondaily smokers as well.

Eligibility criteria

Show full inclusion / exclusion criteria
* 18 years of age or older
* Sufficiently fluent in English to read and comprehend intervention and assessment materials
* Owns a smartphone (Android or iOS only)
* Currently smokes less than daily but at least weekly
* Has smoked 100+ cigarettes lifetime
* Has current intention to quit smoking
* Currently resides in the US
* Can use online survey technology to complete surveys
* Can download, install and use a smartphone app

Where this trial is running

Boston, Massachusetts

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Smoking Cessationsmokingsmartphone appsmoking cessationQuitGuideSmiling instead of Smokingpositive psychologymHealth
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.