Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Testing a smartphone app to help nondaily smokers quit smoking

Official title: Randomized Clinical Trial to Test the Efficacy of a Smartphone App for Smoking Cessation for Nondaily Smokers (SiS4)

Run by Massachusetts General Hospital · NCT06678243 · Data updated 2026-11-12

This study tests a new smartphone app designed to help people who smoke occasionally quit smoking and see if it works better than an existing app.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment1600 (estimated)
SponsorMassachusetts General Hospital
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedDecember 6, 2024
Main results expectedJuly 1, 2027
Study endsJuly 1, 2028
Registry record updatedOctober 13, 2026
Trial IDNCT06678243 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older who smoke less than daily but at least weekly and have a current intention to quit.

Probably not a fit

Patients who smoke daily or do not intend to quit smoking may not receive any benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This project aims to evaluate the effectiveness of a new smartphone app, SiS4, designed specifically for individuals who smoke nondaily and wish to quit. The app incorporates positive psychology exercises and proven smoking cessation tools to support users in their quitting journey. Participants will engage with the app daily for seven weeks, completing online surveys to assess changes in their smoking habits, attitudes, and mental well-being. The study will compare the SiS4 app's effectiveness against an existing app, QuitGuide, to determine which is more beneficial for nondaily smokers.

Why it matters

Potential benefit: If successful, this app could provide a tailored and effective tool for nondaily smokers to successfully quit smoking.

How similar studies have gone: Previous studies have shown promise in using mobile health interventions for smoking cessation, indicating that this approach may be effective for nondaily smokers as well.

Who can join: the full rules

Show full inclusion / exclusion criteria
* 18 years of age or older
* Sufficiently fluent in English to read and comprehend intervention and assessment materials
* Owns a smartphone (Android or iOS only)
* Currently smokes less than daily but at least weekly
* Has smoked 100+ cigarettes lifetime
* Has current intention to quit smoking
* Currently resides in the US
* Can use online survey technology to complete surveys
* Can download, install and use a smartphone app

Where it's running

  • Massachusetts General Hospital
    Boston, Massachusetts, United States
    Recruiting

Study contacts

  • Principal investigator: Bettina Hoeppner, Ph.D., M.S. — Massachusetts General Hospital
  • Study coordinator: Bettina Hoeppner, Ph.D., M.S.
  • Email: bhoeppner@mgh.harvard.edu
  • Phone: 617-643-1988

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.