Personalized treatment to help people with cancer quit smoking and live longer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a multilevel precision tobacco treatment program (PrecisionTx-Onc) that gives personalized risk, benefit, and medication recommendations to clinicians and patients using clinical, genetic, and biomarker data. The intervention is compared to usual care in a 2-arm cluster randomized trial of 16 clinicians and about 96 patients (roughly six patients per clinician) with 1:1 allocation. Primary outcomes include patient receipt of tobacco treatment, medication use, and smoking abstinence measured at six months, along with mechanistic and implementation outcomes. The study is embedded in oncology/hematology clinics and was developed with input from both patients and providers.

Why it matters

Who can join: the full rules

Eligibility Criteria for Clinicians:

* Clinician from participating oncology/hematology clinic
* At least 18 years of age
* Can speak and understand English

Inclusion Criteria for Patients:

* Patient at participating clinic
* Age 18-89 years
* Current smoking (average cigarettes per day ≥5)
* Can speak and understand English
* Willing to consider medication to help reduce craving or smoking such as nicotine patch, lozenge, or varenicline

Exclusion Criteria for Patients:

* Active use of smoking cessation medication (within the past 30 days)
* Receipt of smoking cessation medication or prescription for smoking cessation medication (within the past 30 days)
* Having a contradiction for cNRT or varenicline (allergic reactions, current cardiac problems, pregnancy)
* Patients who were deemed by the investigator to be ineligible for participation in the trial

Where it's running

• John Cochran Veteran's Affairs Medical Center
  St Louis, Missouri, United States Recruiting
• Washington University School of Medicine
  St Louis, Missouri, United States Recruiting

Study contacts

• Principal investigator: Li-Shiun Chen, ScD, M.D., MPH — Washington University School of Medicine
• Study coordinator: Li-Shiun Chen, ScD, M.D., MPH
• Email: li-shiun@wustl.edu
• Phone: 314-362-3932

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.