Investigating nicotine pouches and mini lozenges as alternatives to smoking

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of nicotine pouches and mini lozenges as substitutes for cigarettes among smokers who are not planning to quit in the near future. Participants will use either nicotine pouches, mini lozenges, or no product for one week, followed by a three-week period of attempting to abstain from smoking. The study includes six in-person visits and utilizes a smartphone app for tracking smoking behavior and product use. By comparing these products, the trial seeks to provide valuable data on their potential public health benefits and inform tobacco regulatory policies.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* ≥ 21 years old (i.e., able to legally purchase tobacco products)
* able to read and communicate in English
* no plans to quit smoking in the next 30 days
* willing to stop using nicotine replacement or varenicline
* willing to stop using bupropion (i.e., Wellbutrin, Zyban) if they are currently using it only for smoking cessation
* smoking ≥ 5 cigarettes per day for the past 6 months
* exhaled carbon monoxide ≥ 6 ppm
* no nicotine pouch or smokeless tobacco (including snus) use within the last 6 months

Exclusion Criteria:

* currently in treatment for psychosis or bipolar disorder
* currently taking bupropion for non-smoking cessation reasons (e.g., Wellbutrin for depression)
* currently pregnant or breastfeeding

Where it's running

• University of Wisconsin
  Madison, Wisconsin, United States Recruiting

Study contacts

• Principal investigator: Megan Piper, PhD — University of Wisconsin, Madison
• Study coordinator: Megan Piper, PhD
• Email: mep@ctri.wisc.edu
• Phone: 608-265-5472

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.