Condition

Tobacco Dependence clinical trials and research

• 15Clinical trials
• 5NIH research projects
• 1New in 30 days
• 6Countries

Newest Tobacco Dependence clinical trials

All recruiting trials (15)

• Volitional Help Sheets to Support Smoking Cessation in Clinical Care

  This pilot tests whether adding a short, personalized if-then planning tool helps people in a French clinic quit smoking when used alongside usual care.

  Recruiting Clinique de la Mitterie · Lille · NCT07910214

• Extended tobacco support for people experiencing homelessness

  This program tests whether extending tobacco treatment to 6 months with pharmacist counseling, monthly nicotine replacement deliveries, and phone wellness coaching helps adults experiencing homelessness quit smoking compared with a 3-month package.

  Recruiting Phase 4 University of California, San Francisco · San Francisco, California · NCT07148232

• Semaglutide to help people with type 2 diabetes quit smoking

  This pilot will test whether adding semaglutide to combination nicotine replacement helps adults with type 2 diabetes quit smoking and limits post-quit weight gain.

  Recruiting Phase 3 Ottawa Heart Institute Research Corporation · Ottawa, Ontario · NCT07059377

• Varenicline-based approach to help Veterans who smoke see if they can reduce smoking and try to quit

  This study tests whether varenicline, plus motivational support, helps Veterans who aren’t ready to quit reduce smoking and make quit attempts.

  Recruiting at 3 sites Phase 4 VA Office of Research and Development · San Diego, California and 3 other locations · NCT06966362

• A program to help people quit smoking using CBT and mindfulness audio support

  This study is testing if combining text messages for quitting smoking with mindfulness audio support helps people stop smoking better than just using text messages alone.

  Recruiting Sir Run Run Shaw Hospital · Hangzhou · NCT06901713

• Quitting Matters: a smoking quit program for people living with HIV

  This 6-month program will test whether a tailored smartphone app plus nicotine patches and gum helps people living with HIV quit smoking better than a standard quit app.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT06883097

• Improving tobacco cessation support for patients in poverty in Utah

  This study is testing new ways to help people living in poverty in Utah quit smoking by using support tools and strategies in their healthcare clinics.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06881069

• AI Molar Mind to help people quit smoking with oral health feedback

  This study will test whether AI Molar Mind, a digital tool that reviews your oral health and gives personalized feedback, can help adults who smoke at least five cigarettes a day quit smoking.

  Recruiting Fayoum University · Fayoum, Alexandria Governorate · NCT06762210

• Smoking cessation for parents with health navigator support to tackle social needs

  We’re testing a program that helps parents quit smoking and also addresses their social challenges to reduce kids’ exposure to secondhand smoke.

  Recruiting at 3 sites St. Justine's Hospital · Montreal, Quebec and 2 other locations · NCT06651684

• Reducing harm for smokers with mental illness using e-cigarettes

  This study is testing whether giving e-cigarettes with or without online support can help daily smokers with serious mental illness manage stress and reduce harm, even if they aren't ready to quit smoking yet.

  Recruiting at 2 sites Dartmouth-Hitchcock Medical Center · Louisville, Kentucky and 1 other locations · NCT06543407

• Yoga to help reduce tobacco cravings

  This study is testing if yoga can help people who are dependent on tobacco reduce their cravings and possibly quit smoking.

  Recruiting University of Pittsburgh · Bengaluru, Karnataka · NCT06488443

• Using cannabidiol to help reduce cigarette smoking

  This study is testing if taking cannabidiol (CBD) can help people who want to quit smoking cigarettes reduce their tobacco use.

  Recruiting Phase 2 University of California, Los Angeles · North Hollywood, California · NCT06218056

• Smoke-free home initiative for subsidized housing residents

  This study is testing a smoke-free initiative in subsidized housing to see if it helps residents stop smoking and create healthier homes.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06170437

• Exploring the effects of nicotine pouches on daily smokers

  This study is testing whether using a new nicotine pouch can help daily smokers cut down on their cigarette use and improve their health.

  Recruiting at 2 sites Milton S. Hershey Medical Center · Hershey, Pennsylvania and 1 other locations · NCT06043362

• Using Cannabidiol to Help People Quit Smoking

  This study is testing if taking cannabidiol (CBD) can help people who smoke more than 10 cigarettes a day quit smoking and feel better during withdrawal.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT05445804

NIH-funded research (5)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• A new therapeutic approach to help adults quit smoking

  A new treatment being developed to help adults stop smoking, including young adults, using a novel therapeutic approach.

  NIH research Flik Therapeutics, INC. · Philadelphia, United States · NIH-11453254

• Motivational Interviewing and Mindfulness-Only Recovery for Tobacco and Other Drug Use in Methadone Treatment

  A new program combines motivational interviewing and mindfulness-based therapy to help people on methadone treatment quit tobacco and other drugs at the same time.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11382249

• Mindfulness and motivational coaching to help people on methadone quit smoking and reduce other drug use

  This program offers group mindfulness training plus motivational coaching for people on methadone to help them stop smoking and cut down other drug use.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11364696

• A mentoring program to improve tobacco dependence research.

  This study is creating a mentoring program to help new researchers learn how to improve treatments for people trying to quit smoking, making sure they work well for different individuals based on their unique needs.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11080886

• Helping people in methadone treatment quit smoking and other drugs

  This study is looking for people in methadone treatment for opioid use who also smoke, to try out a new 8-week group program that teaches mindfulness and emotional skills to help them feel better and reduce their chances of relapsing into substance use.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-10589481

Related topics

Quick answers

How many Tobacco Dependence clinical trials are recruiting right now?

15, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (9 trials), Canada (2 trials), India (1 trial), France (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 3: 1, Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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