Improving smoking cessation in the African American community with extended bupropion treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the effectiveness of extended bupropion treatment for smoking cessation among African American daily smokers. Participants will be randomly assigned to receive either 6 months of bupropion or the standard 7 weeks of treatment, along with culturally-relevant smoking cessation counseling. The study aims to enhance abstinence rates by providing support tailored to the needs of the participants. A total of 500 individuals will be enrolled and followed for 12 months to assess outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* African American
* age \>18 years
* interested in quitting
* smoked \>1 cpd for \>1 years
* smoked on \>25 days in the past month
* willing to take 6 months of study medication and complete all visits
* have a home address and functioning telephone number

Exclusion Criteria:

* Consistent with contraindications for bupropion:
* use of psychoactive medications
* history of alcohol or substance abuse within the past year
* binge drinking (\>5 drinks on one occasion) \>2 times in the past month
* history of seizures or head trauma; history of bulimia or anorexia nervosa
* pregnant (as measured by over the counter pregnancy test kit for women of child-bearing age only) or contemplating pregnancy; breast feeding
* myocardial infarction in the past 2 months
* reported use of opiates, cocaine, or stimulants
* unstable diabetes
* bupropion is a known inhibitor of the liver enzyme CYP2D6, so those taking drugs known to be higher metabolized by this enzyme (e.g., metoprolol, tamoxifen) will be excluded.
* use of stop smoking medications (bupropion, varenicline, nicotine replacement, fluoxetine, clonidine, buspirone, or doxepin) in the past 30 days
* planning to move from the Kansas City area in the next year
* other smoker in household enrolled in the study.

Where it's running

• University of Kansas Medical Center
  Kansas City, Missouri, United States Recruiting

Study contacts

• Principal investigator: Lisa Sanderson Cox, PhD — University of Kanas Medical Center
• Study coordinator: Tricia Snow, MPH
• Email: psnow@kumc.edu
• Phone: 816-398-8960

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.