Condition

Tobacco Use clinical trials and research

• 38Clinical trials
• 79NIH research projects
• 6Countries

Newest Tobacco Use clinical trials

All recruiting trials (38)

• One extra structured CBT session to help cancer patients quit smoking

  This trial tests whether adding one CBT-based smoking-cessation session to standard brief counseling helps cancer patients quit smoking cigarettes.

  Recruiting Vietnam National Cancer Hospital · Hanoi · NCT07822464

• Relapse-prevention counseling added to standard care for cancer patients who quit smoking at diagnosis

  This trial tests whether adding one structured CBT-based relapse-prevention session helps cancer patients who have remained smoke-free since diagnosis stay abstinent longer.

  Recruiting Vietnam National Cancer Hospital · Hà Nội · NCT07815912

• Automating Tobacco Cessation in Primary Care

  This project tests a workflow in primary care to identify smokers and help them access nicotine replacement therapy (NRT) during routine visits.

  Recruiting University of Pennsylvania · Philadelphia, Pennsylvania · NCT07735286

• Text2Quit-Kenya: a mobile message program to help ED patients quit tobacco

  Researchers will test a text message-based smoking-cessation program with Kenyan emergency department patients to see if it helps people quit and learn what works in this setting.

  Recruiting Yale University · Nairobi · NCT07734727

• How people puff IQOS Iluma i vs IQOS 2.4 and how flavors feel

  This study tests how exclusive IQOS users puff the newer Iluma i versus the older 2.4, and whether preferred flavor affects puffing and sensory experience.

  Recruiting at 2 sites American University of Beirut Medical Center · Beirut, Beirut and 1 other locations · NCT07712887

• Feasibility of a perinatal smoking and cannabis cessation program

  This study tests a perinatal program to help pregnant people quit tobacco and cannabis and stay smoke-free after birth.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07489443

• Structured management of adult cardiovascular risk factors in outpatient care

  This project will try a structured clinic approach to managing blood pressure, cholesterol, diabetes, and weight in adults with cardiovascular risk factors to see if it improves risk control and outcomes.

  Recruiting Universidad Católica San Antonio de Murcia · Santiago, Santiago Metropolitan · NCT07447362

• Telegram-based smoking-cessation support after heart attack

  This trial tests whether a 6-month Telegram chatbot program helps people who had a heart attack quit smoking more often than standard care alone.

  Recruiting ITMO University · Ulyanovsk, Ulyanovsk Oblast and 1 other locations · NCT07230249

• Choice-based harm-reduction sampling to help people not ready to quit smoking

  This project will test whether letting smokers who aren't ready to quit choose and try a harm-reduction product (an e-cigarette or a nicotine pouch) leads to less cigarette use over six months than giving a nicotine patch plus lozenge.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT07199517

• Community-based effort to boost lung cancer screening with navigators

  This project tests whether a navigator-led program in community health centers can help people eligible for lung cancer screening and support tobacco treatment use.

  Recruiting Baystate Medical Center · Springfield, Massachusetts · NCT07168629

• How cigarillo flavor rules affect young adult cigarillo use (Project CLARITY)

  This study will test whether different cigarillo flavor types and additives make cigarillos more appealing and change smoking, switching, or quitting behavior in 18–24-year-olds who currently use cigarillos.

  Recruiting University of Oklahoma · Oklahoma City, Oklahoma and 1 other locations · NCT07162935

• Extended tobacco support for people experiencing homelessness

  This program tests whether extending tobacco treatment to 6 months with pharmacist counseling, monthly nicotine replacement deliveries, and phone wellness coaching helps adults experiencing homelessness quit smoking compared with a 3-month package.

  Recruiting Phase 4 University of California, San Francisco · San Francisco, California · NCT07148232

• Abuse potential of five modern oral nicotine products

  This will test how five modern oral nicotine products compare with cigarettes and nicotine gum in how satisfying they feel and how much nicotine adult smokers absorb.

  Recruiting RAI Services Company · Overland Park, Kansas · NCT07132814

• Effects of Semaglutide on Smoking and Health in Obese Adults

  This study is testing if a medication called semaglutide can help obese adults who smoke reduce their cravings and improve their health over 12 weeks.

  Recruiting Phase 4 University of Oklahoma · Oklahoma City, Oklahoma · NCT06986993

• How short-term smoking abstinence changes brain pain processing in people who smoke with or without chronic low back pain

  This will test whether 24-hour smoking abstinence increases pain sensitivity in the brain and makes quitting harder for adults who smoke, including those with chronic low back pain.

  Recruiting Duke University · Durham, North Carolina · NCT06983678

• E-cigarettes versus nicotine patches and lozenges to help people in substance-use treatment quit smoking

  This trial will test whether switching completely to e-cigarettes helps adults in outpatient substance use treatment quit smoking compared with using nicotine patches and lozenges.

  Recruiting at 4 sites Medical University of South Carolina · Charleston, South Carolina and 3 other locations · NCT06922617

• Improving tobacco cessation support for patients in poverty in Utah

  This study is testing new ways to help people living in poverty in Utah quit smoking by using support tools and strategies in their healthcare clinics.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06881069

• Scalable tobacco-cessation support for cancer survivors and their caregivers

  This project will try a tailored tobacco-cessation program plus provider training to help cancer survivors and their caregivers quit using tobacco.

  Recruiting University of Florida · Gainesville, Florida · NCT06851936

• Effects of Low Nicotine Cigarettes on Chronic Pain and Cravings

  This study tests if switching to very low nicotine cigarettes can help people with chronic pain who smoke and are being treated for opioid addiction by reducing their cravings and pain levels.

  Recruiting Duke University · Durham, North Carolina · NCT06747871

• Non-endoscopic test to find Barrett's esophagus in veterans without chronic reflux.

  This project will test whether a simple, non-endoscopic swab-like test can find Barrett's esophagus in veterans over 40 who have risk factors for esophageal cancer but no chronic heartburn.

  Recruiting Louis Stokes VA Medical Center · Cleveland, Ohio · NCT06746623

• Using an air quality monitor to encourage smoke-free homes for cancer patients

  This study is testing if using an air quality monitor can help cancer patients who smoke create smoke-free homes and quit smoking.

  Recruiting at 7 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT06693700

• Investigating how sleep affects smoking cessation

  This study is testing whether improving sleep can help adults trying to quit smoking stay smoke-free longer by comparing two different support methods.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT06609369

• Impact of THC on E-Cigarette Use Behavior

  This study is testing how different doses of THC affect daily e-cigarette users' cravings and use behavior.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT06609109

• Impact of THC on Cigarette Smoking Behavior

  This study is testing how different amounts of THC affect smoking habits and cravings in healthy adults who smoke cigarettes and use cannabis.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT06609083

• Comparing mobile health screening to traditional methods for early detection of oral cancer in rural Varanasi.

  This study tests if using mobile health screenings can help find oral cancer earlier than traditional methods for people living in rural Varanasi.

  Recruiting Memorial Sloan Kettering Cancer Center · New York, New York · NCT06535867

• Helping pregnant women quit smoking with community health workers

  This study is testing a new program that uses community health workers to help pregnant women in San Bernardino County quit smoking by providing support through home visits.

  Recruiting Loma Linda University · Loma Linda, California and 1 other locations · NCT06438549

• Evaluating e-cigarettes and nicotine pouches for smokers

  This study is testing whether e-cigarettes or nicotine pouches can help long-term smokers quit regular cigarettes and reduce their smoking habits over six weeks.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06372899

• Little cigar exposure and oxidative stress markers in adult smokers

  We will test whether using high- or low-oxidant little cigars changes markers of oxidative stress compared with your usual cigarette in adult daily cigarette smokers.

  Recruiting Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT06310187

• Evaluating how flavor affects smokers switching to e-cigarettes

  This study tests whether different e-cigarette flavors can help smokers switch from regular cigarettes to e-cigarettes more easily.

  Recruiting Abramson Cancer Center at Penn Medicine · Philadelphia, Pennsylvania · NCT06264154

• Using motivational interviewing and mindfulness to help reduce substance use

  This study is testing whether combining motivational interviewing and mindfulness techniques can help people who struggle with using multiple substances, like opioids and tobacco, to reduce their use.

  Recruiting at 2 sites Phase 3 Rutgers, The State University of New Jersey · New Brunswick, New Jersey and 1 other locations · NCT06033599

• How marijuana (THC) and tobacco interact when used together

  This test tries to see if combining marijuana (THC) and tobacco changes blood drug levels and how people feel and respond physically in adults who regularly use both.

  Recruiting Phase 2 University of California, San Francisco · San Francisco, California · NCT05999383

• Effects of very low nicotine cigarettes on heart health

  This study is testing how smoking very low nicotine cigarettes affects heart health in both daily and occasional smokers.

  Recruiting Early Phase 1 Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT05707871

• Harm reduction approach for people with HIV who smoke cigarettes

  This study is testing a new way to help people with HIV who smoke cigarettes by focusing on reducing their smoking and managing health risks instead of just trying to get them to quit completely.

  Recruiting Montefiore Medical Center · The Bronx, New York · NCT05642715

• Understanding brain activity related to smoking lapses

  This study is trying to see how brain activity changes in adults who smoke right before they might slip up and have a cigarette after trying to quit.

  Recruiting Penn State University · University Park, Pennsylvania · NCT05572671

• Helping smokers practice quitting tobacco

  This study is testing a new way to help smokers practice quitting tobacco by trying short breaks from smoking without pressure, comparing it to regular counseling, to see which method helps them make more quit attempts over six months.

  Recruiting Phase 1/2 Rush University Medical Center · Chicago, Illinois · NCT05513872

• Using Cannabidiol to Help People Quit Smoking

  This study is testing if taking cannabidiol (CBD) can help people who smoke more than 10 cigarettes a day quit smoking and feel better during withdrawal.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT05445804

• Using brain stimulation to help people quit smoking

  This study is testing if a special brain treatment can help people quit smoking by focusing on specific areas of the brain that are linked to tobacco addiction.

  Recruiting at 2 sites Medical University of South Carolina · Charleston, South Carolina and 1 other locations · NCT04903028

• Lung macrophage patterns in COPD-susceptible smokers

  This study tests whether lung macrophage features differ in smokers who may be at risk for COPD, by comparing people with and without air trapping but with preserved lung function.

  Recruiting University of California, San Francisco · San Francisco, California and 2 other locations · NCT04722835

NIH-funded research (newest 40 of 79)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Ending Tobacco Use with a Smartphone Program for Cambodian People Living with HIV/AIDS

  A smartphone-based quit-smoking program designed for people living with HIV/AIDS in Cambodia to help reduce tobacco use alongside HIV treatment.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11535291

• Optimizing lung cancer care with smart tools for prevention, early detection, treatment, and survivorship

  A U01 grant using AI and biomarkers to improve lung cancer prevention, screening, treatment, and survivorship care for people at risk or living with lung cancer.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11495828

• How deforestation affects alcohol and tobacco use in Indonesia

  This project looks at whether forest loss in Indonesia is linked to changes in people's tobacco and alcohol use across different places and years.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11458627

• Dynamic patterns of oral nicotine pouch use and tobacco transitions in adults

  A long-term study is following adults to understand how people start, switch, or stop using oral nicotine pouches, cigarettes, and other tobacco products.

  NIH research University of Vermont & St Agric College · Burlington, United States · NIH-11427892

• Modeling how tobacco rules affect real people in the US

  A project uses computer models to estimate how flavor bans and other tobacco policies might change smoking and related health outcomes for different groups of people.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11421862

• Phone text program to help people with HIV in Uganda and Zambia stop smoking

  This program uses tailored text messages and nicotine patches to help people living with HIV in Uganda and Zambia quit tobacco.

  NIH research Univ of Maryland, College Park · College Park, United States · NIH-11418843

• Refer 2 Quit: Proactively Reach Household Members Who Smoke Through Pediatric Care

  A program to help families where a child is exposed to tobacco by promoting and linking adults in the home to proven quitting support through pediatric clinics.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11413481

• Ending Tobacco Use with a smartphone program for Cambodians living with HIV

  A smartphone-based, tailored smoking-cessation program for people living with HIV in Cambodia is being tested to help them quit smoking.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11413458

• Tailored smartphone messages to help Cambodians with HIV quit smoking

  A smartphone program that sends personalized messages and offers medications to help adults living with HIV in Cambodia stop smoking.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11401633

• AppalTRuST Project 2: Tobacco marketing exposure and future use among Appalachian young adults

  A study in rural Appalachian Kentucky examines how exposure to tobacco marketing for new products relates to future tobacco use among young adults.

  NIH research University of Kentucky · Lexington, United States · NIH-11394490

• AppalTRuST Project: How tobacco rules affect rural Kentucky adults

  A large, long-term study in Appalachian Kentucky will follow 2,000 adults to see how changes in tobacco regulations influence tobacco use and related beliefs over time.

  NIH research University of Kentucky · Lexington, United States · NIH-11394485

• Remote, young adult-led help to quit vaping and prevent tobacco use among teens

  A youth-friendly behavioral and digital program led by remote lay counselors aims to help high school students quit vaping and prevent them from starting or escalating tobacco use.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11391375

• Modeling how age-restricted in-person tobacco sales could affect youth tobacco use

  A project at Ohio State University explores whether letting only adults buy tobacco in age-restricted shops could lower how many youths use tobacco.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11385912

• Understanding how stress and social factors affect young adults’ tobacco use over time

  This study follows young adults across the U.S. to see how stress, mental health, and parenting experiences shape the way they use tobacco products over several years.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11379555

• Cannabis legalization and its effects on youth and adult nicotine and tobacco use

  This project looks at how legal cannabis, now available in more places, might change how people—especially young people and adults—use tobacco and nicotine.

  NIH research Yale University · New Haven, United States · NIH-11369124

• How stress at different levels affects young adults' smoking and vaping

  This project looks at how life stress, mental-health symptoms, and social pressures relate to smoking, vaping, and using multiple tobacco products among young adults across the U.S.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11362790

• How e-cigarette rules affect youth smoking and vaping

  This grant studies how laws about e-cigarettes—like flavor bans, age limits, and taxes—affect how many youths and young adults use vaping and traditional tobacco products.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11357625

• VR-based attentional bias as a biomarker for tobacco use disorder

  A study at UC San Diego is testing a virtual reality task to see if attentional bias can serve as a biomarker to help treat cigarette addiction.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11350932

• Helping homeless-experienced veterans quit smoking using rewards-based support in VA housing

  A funding-opportunity-like grant to test a rewards-based program that helps veterans who have experienced homelessness quit smoking while living in VA housing.

  NIH research VA Greater Los Angeles Healthcare System · Los Angeles, United States · NIH-11350018

• Menthol bans and tobacco use patterns among menthol smokers

  This study tests how banning menthol in cigarettes and e-cigarettes affects how adults who smoke menthol cigarettes use tobacco products.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-11326736

• Tobacco use patterns over time in diverse U.S. adults and youth

  This project looks at how different groups of U.S. adults and young people start, stop, or switch between tobacco products and what influences those patterns.

  NIH research George Washington University · Washington, United States · NIH-11320880

• How state rules limit local tobacco control and affect disparities

  This grant studies how state preemption of local tobacco rules affects who uses tobacco and who is exposed to tobacco, with the goal of reducing disparities.

  NIH research George Washington University · Washington, United States · NIH-11305311

• New ways to reduce socioeconomic gaps in tobacco use

  A patient-friendly plan to map how social and personal factors influence smoking and to test a flexible, multilevel plan that could help people with fewer resources quit.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11303079

• Nicotine Pouches and Cancer Risk: How Adults Move Between Pouches and Smoking

  Researchers are studying how adults use nicotine pouches and cigarettes and what this means for cancer risk and quitting behavior.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11287509

• Why young adults use both marijuana and cigarettes

  This project looks at how young adults who use both marijuana and cigarettes make choices between them using short lab tasks that mimic real-life tradeoffs.

  NIH research Brown University · Providence, United States · NIH-11237996

• Community health worker support to help people with serious mental illness quit smoking

  This project trains Medicaid behavioral health staff to act as community health workers who help adults with serious mental illness stop using tobacco.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11225257

• Remote youth program with young-adult counselors and an app to help teens stop vaping and avoid cigarettes

  This program offers teens remote support from young-adult counselors plus a smartphone app to help them stop vaping and avoid starting cigarette smoking.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11187243

• Circuity-guided rTMS for tobacco use in Veterans: comparing insula and prefrontal targets

  A study tests a brain-stimulation approach to help Veterans quit smoking by comparing two brain targets to reduce cravings and smoking.

  NIH research Ralph H Johnson VA Medical Center · Charleston, United States · NIH-11183949

• Tobacco quitting support for people living with HIV in Kisumu County, Kenya

  This project brings tobacco‑cessation help into HIV clinics so people living with HIV in Kisumu can get counseling and support to quit tobacco.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11174528

• Getting household smokers help through your child's pediatrician

  This project offers help from pediatric clinics to connect adults in your home who smoke with quitting support so children are less exposed to secondhand smoke.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11171656

• Smoking-cessation meds with a team approach for people with HIV (SMARTTT)

  A multi-site study tests a team-based plan using medication and rewards to help people with HIV quit smoking.

  NIH research Yale University · New Haven, United States · NIH-11169520

• How flavor bans on cigarettes, cigars, and e-cigarettes could change smoking and health

  Using computer models, researchers will predict how flavor bans on cigarettes, cigars, and e-cigarettes might change tobacco use and health risks for different groups of people in the U.S.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11168770

• Using virtual reality to understand how attention affects tobacco addiction

  This study is looking at how daily tobacco users react to virtual reality situations that remind them of smoking, to see if their attention to these cues can help predict how well they might do with quitting smoking, especially when using a medication called varenicline compared to a placebo.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11164800

• How tobacco marketing affects young adults in Appalachian Kentucky

  This project looks at whether seeing ads for new and flavored tobacco products influences tobacco use and attitudes among young adults in rural Appalachian communities.

  NIH research University of Kentucky · Lexington, United States · NIH-11163566

• Tobacco use patterns in Appalachian Kentucky adults

  This project follows adults in Appalachian Kentucky to track tobacco use, attitudes, and exposures over time to see how FDA tobacco rules affect people in rural communities.

  NIH research University of Kentucky · Lexington, United States · NIH-11163563

• Helping Cambodian people living with HIV quit smoking using tailored smartphone messages and support

  A program offers personalized smartphone messages plus medication and counseling to help Cambodian adults living with HIV stop smoking.

  NIH research H. Lee Moffitt Cancer Ctr & Res Inst · Tampa, United States · NIH-11163553

• Limiting tobacco sales to adult-only shops to protect young people

  This project uses computer models to see if allowing tobacco sales only in tobacco shops or other adult-only stores could cut tobacco access and exposure for teens and young adults.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11161563

• Understanding How E-cigarette Policies Affect Youth Tobacco Use

  This project looks at how different rules about e-cigarettes, like flavor bans and age limits, influence whether young people use e-cigarettes and other tobacco products.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11160425

• How cannabis laws affect nicotine and tobacco use in young people and adults

  This project explores how changes in cannabis laws might influence how young people and adults use nicotine and tobacco products.

  NIH research Yale University · New Haven, United States · NIH-11141006

• Home food delivery to help rural Black/African American smokers quit

  This project is testing whether regular home food deliveries help rural Black/African American smokers in the Arkansas Delta stop smoking.

  NIH research Univ of Arkansas for Med Scis · Little Rock, United States · NIH-11137717

Related topics

Quick answers

How many Tobacco Use clinical trials are recruiting right now?

38, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in United States (32 trials), Vietnam (2 trials), Russia (1 trial), Lebanon (1 trial), Chile (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 4: 2, Phase 2: 2, Early Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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