Quit-smoking support for adults with HIV or TB in South Africa
Official title: Treatment Development for Smoking Cessation and Engagement in HIV/TB Care in South Africa
Funded at Massachusetts General Hospital · NIH-11379030 · Data updated 2026-11-12
This project will create and try smoking-cessation support for adults with HIV or TB in South Africa to help them quit and stay on treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | August 1, 2023 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $81,305 |
| NIH project number | 3R34DA057169-03S1 |
| Project ID | NIH-11379030 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 21 and older in South Africa who are living with HIV and/or recently diagnosed with TB and who currently smoke would be the ideal participants.
✕Less likely to help
People who do not smoke, are under the study age cutoff, live outside South Africa, or are unwilling to attend clinic visits and counseling are unlikely to benefit from joining.
What this research studies
If you join, you would be offered counseling based on cognitive behavioral therapy that is adapted for people living with HIV and those being treated for TB in South Africa. The team will tailor the program to local clinics and ways of delivering care, then try it out with people who smoke to see if it is acceptable and practical. They will include measures to support taking HIV and TB medicines and will check smoking status with biological tests. Study staff will also track treatment adherence and health indicators like viral load and TB treatment outcomes to see if quitting helps overall care.
Why it matters
Potential benefit: If successful, this could help people with HIV or TB stop smoking and improve adherence to HIV and TB treatments, potentially reducing illness and death.
How similar studies have gone: Earlier trials by the team showed higher biologically-verified quit rates among people with HIV in the US and improved ART adherence in Cape Town, supporting this approach though combining smoking cessation with HIV/TB care in South Africa is a new application.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: O'cleirigh, Conall Michael — Massachusetts General Hospital
- Study coordinator: O'cleirigh, Conall Michael
Related research
Other NIH-funded projects on the same topics.
-
Social stress and smoking: why disadvantaged young adults struggle to quit
This grant looks at how daily social stress affects if and when disadvantaged young adults who smoke can quit and stay quit.
-
I-STOP: a mobile health program to help people with HIV quit smoking
A smartphone-based program designed to help people with HIV quit smoking in a sustainable, affordable way.
-
Smoking cessation help for people with HIV in South Africa
A program is being tested to help people living with HIV in South Africa quit smoking in ways that fit low-resource clinics and show good value.
-
Mobile tools to understand how sleep affects quitting smoking
This project uses a smartphone to track sleep and smoking in lower-income adults trying to quit to find how sleep patterns relate to staying smoke-free.
-
Integrated approach to lung screening and quitting for African Americans
A multi-level program aims to boost LDCT lung cancer screening uptake and help African American smokers quit, with support from a comprehensive community-focused plan.
-
Peer-led smoking-cessation program for public housing residents
A peer-led program with eight group sessions plus nicotine replacement therapy is tested on adults living in public housing to help them quit smoking.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.