Quit-smoking support for adults with HIV or TB in South Africa
Treatment Development for Smoking Cessation and Engagement in HIV/TB Care in South Africa
This project will create and try smoking-cessation support for adults with HIV or TB in South Africa to help them quit and stay on treatment.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11379030 on NIH RePORTER |
What this research studies
If you join, you would be offered counseling based on cognitive behavioral therapy that is adapted for people living with HIV and those being treated for TB in South Africa. The team will tailor the program to local clinics and ways of delivering care, then try it out with people who smoke to see if it is acceptable and practical. They will include measures to support taking HIV and TB medicines and will check smoking status with biological tests. Study staff will also track treatment adherence and health indicators like viral load and TB treatment outcomes to see if quitting helps overall care.
Who could benefit from this research
Good fit: Adults aged 21 and older in South Africa who are living with HIV and/or recently diagnosed with TB and who currently smoke would be the ideal participants.
Not a fit: People who do not smoke, are under the study age cutoff, live outside South Africa, or are unwilling to attend clinic visits and counseling are unlikely to benefit from joining.
Why it matters
Potential benefit: If successful, this could help people with HIV or TB stop smoking and improve adherence to HIV and TB treatments, potentially reducing illness and death.
How similar studies have performed: Earlier trials by the team showed higher biologically-verified quit rates among people with HIV in the US and improved ART adherence in Cape Town, supporting this approach though combining smoking cessation with HIV/TB care in South Africa is a new application.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: O'cleirigh, Conall Michael — Massachusetts General Hospital
- Study coordinator: O'cleirigh, Conall Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.