Condition

Lung Cancer Screening clinical trials and research

• 16Clinical trials
• 96NIH research projects
• 5Countries

Newest Lung Cancer Screening clinical trials

All recruiting trials (16)

• Empowering patients to get lung cancer screening with support and navigation

  This pilot study tests a patient navigation and education program to see if it helps adults who are eligible start and complete low-dose CT lung cancer screening.

  Recruiting at 13 sites University of California, Irvine · Anaheim, California and 56 other locations · NCT07711691

• Quality Implementation of Lung Cancer Screening in Kentucky

  This project tests how well the QUILS system helps Kentucky lung cancer screening programs work together to screen at-risk residents more effectively.

  Recruiting at 17 sites University of Kentucky · Ashland, Kentucky and 16 other locations · NCT07682610

• Statewide Lung Cancer Screening Improvement in Nevada and Mississippi using the QUILS System

  This project tests whether a QUILS-based statewide initiative can expand and sustain high-quality lung cancer screening for people in Mississippi and Nevada.

  Recruiting at 13 sites University of Kentucky · Greenville, Mississippi and 12 other locations · NCT07682597

• Quality Improvement Implementation for Lung Cancer Screening (QUILS) Program Enhancement

  This project tests a quality improvement pathway in existing lung cancer screening programs to help identify and prioritize process changes that improve quality and patient retention.

  Recruiting at 17 sites University of Kentucky · Ashland, Kentucky and 16 other locations · NCT07639255

• Methylation markers from saliva to guide lung cancer screening

  This study tests whether DNA methylation patterns in saliva can more accurately identify people who should get a low-dose CT scan for lung cancer screening.

  Recruiting University Hospital, Antwerp · Antwerp, Antwerpen · NCT07631624

• Multilevel program to increase LDCT lung cancer screening and help African American smokers quit

  This program will try combining low-dose CT screening with culturally tailored smoking-cessation support to help African American smokers who are eligible for LDCT quit and get screened.

  Recruiting at 2 sites Louisiana State University Health Sciences Center in New Orleans · New Orleans, Louisiana and 1 other locations · NCT07576595

• Precision lung cancer screening using AI risk scores and blood biomarkers

  This project will test whether the Sybil AI tool and optional blood tests can better predict lung cancer risk for people aged 50–80 getting low-dose CT scans, including those who meet expanded screening rules beyond current USPSTF guidance.

  Recruiting at 2 sites University of Illinois Chicago · Chicago, Illinois and 1 other locations · NCT07408531

• Akershus Cardiac Examination (ACE) 5

  This project tests whether using the chest CT scans from lung cancer screening to look for coronary artery calcium can help find hidden heart disease in people aged 60–79 with heavy smoking histories.

  Recruiting University Hospital, Akershus · Lørenskog, Akershus · NCT07301489

• Text messages to boost lung cancer screening participation

  This trial will test whether sending tailored text messages to adults aged 50–80 with a 20+ pack-year smoking history can increase completion of lung cancer screening compared with mailed educational materials.

  Recruiting University of Rochester · Rochester, New York · NCT07227480

• CONNECT Multilingual: Helping Spanish and Cantonese Speakers Quit Smoking During Lung Cancer Screening

  This trial tests a multilingual version of the CONNECT program to help current adult smokers who speak Spanish or Cantonese quit smoking while undergoing lung cancer screening.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07111936

• Developing and validating a blood test that reads DNA methylation to diagnose lung cancer

  This project will test a blood test that looks at DNA changes to see if it can detect lung cancer in people being screened or treated.

  Recruiting University of Maryland, Baltimore · Glen Burnie, Maryland · NCT07008664

• Understanding patient experiences with lung cancer screening

  This study is trying to understand what makes it hard for people to get lung cancer screenings and how their experiences with scheduling these screenings can be improved.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT06872723

• Lung cancer screening for people with unexplained weight loss

  This study is testing if people who have lost weight for no clear reason are more likely to have lung cancer and will use special scans and blood tests to find out.

  Recruiting at 8 sites Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 7 other locations · NCT06717334

• Prediction-augmented lung cancer screening: a pragmatic VA trial

  This trial tests whether using prediction models to identify Veterans who would benefit most from lung cancer screening can be feasibly implemented at the point of care and increase screening uptake.

  Recruiting VA Office of Research and Development · Bedford, Massachusetts and 3 other locations · NCT06538636

• Counseling methods for quitting smoking

  This study is testing whether video counseling can help older smokers quit smoking just as well as traditional in-person counseling.

  Recruiting Scientific Institute San Raffaele · Milan, Italy, Milan · NCT06451029

• Lung cancer screening using low-dose CT scans in women

  This study is testing if low-dose CT scans can help find lung cancer earlier in women aged 50 to 74 who have a history of smoking, by comparing how well different radiologists read the scans and seeing if artificial intelligence can help too.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT05195385

NIH-funded research (newest 40 of 96)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Digital health strategies to expand lung cancer screening in safety-net clinics

  A funded project aims to help low-resource clinics increase the use of lung cancer screening for patients who smoke or are at risk.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11509378

• Integrated approach to lung screening and quitting for African Americans

  A multi-level program aims to boost LDCT lung cancer screening uptake and help African American smokers quit, with support from a comprehensive community-focused plan.

  NIH research Lsu Health Sciences Center · New Orleans, United States · NIH-11491488

• Population health approach to boost lung cancer screening at community clinics

  A large Utah project aims to help community clinics reach more eligible adults to get low-dose CT lung cancer screening.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11457456

• Group-based tobacco treatment for older adults after lung cancer screening

  A study tests a group-based tobacco cessation program for older adults who are getting lung cancer screening to help them quit smoking.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11447151

• Personalized Lung Cancer Screening for Veterans

  Aimed at improving who gets screened and how lung cancer is diagnosed among Veterans using personalized tools.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11446454

• Proteogenomic framework to improve lung cancer screening with biomarkers

  A biomarker-based approach aims to refine LDCT lung cancer screening so more cancers are caught early while reducing unnecessary procedures.

  NIH research International Agency for Res on Cancer · Lyon, France · NIH-11427685

• Using quitlines to spread lung cancer screening information to people who smoke

  A large cancer center project will test two ways of delivering lung cancer screening information to adults who smoke, using quitlines as a trusted channel to reach them.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11425785

• Using lung CT scans to spot COPDearly and help people

  A researcher team will use data from lung cancer screening CT scans to improve COPD screening and help people at risk get diagnosed sooner.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11400493

• A community health worker program to boost lung cancer screening at local clinics

  A nurse/health worker team works with people at community clinics to help them learn about lung cancer screening and make it easier to get screened.

  NIH research Baystate Medical Center, INC. · Springfield, United States · NIH-11395317

• Understanding how real-world lung cancer screening works across diverse populations

  A real-world study to see how lung cancer screening affects people in everyday clinical settings, beyond highly controlled trials.

  NIH research Dartmouth College · Hanover, United States · NIH-11394614

• Lung cancer care coordination for AI/AN communities in Oklahoma

  A cancer care project helps AI/AN patients in Oklahoma get coordinated, timely cancer care through telehealth huddles between tribal health services and an NCI-designated cancer center.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11383147

• Buccal cell screening with AI heatmap to detect early lung cancer

  A home-based cheek-swab test using AI analysis of cheek cell DNA architecture aims to flag people at risk for early lung cancer so they can get confirmatory imaging like CT scans.

  NIH research Northwestern University · Chicago, United States · NIH-11381218

• How well lung cancer screening works for real-world patients

  This project combines medical claims, screening registries, and national survey data to find which lung cancer screening approaches help real-world patients the most.

  NIH research Dartmouth College · Hanover, United States · NIH-11377737

• Centering Care to Improve Lung Cancer Screening Follow-Up in Real-World Settings

  A researcher is testing a centralized way to improve how people return for lung cancer screening follow-up in real-world clinics.

  NIH research Fred Hutchinson Cancer Center · Seattle, United States · NIH-11377151

• Lung cancer screening for veterans in community care: how to improve care and follow-up

  This project looks at how to make lung cancer screening better for veterans who get care outside VA facilities, focusing on keeping people up to date with follow-up and improving communication.

  NIH research Portland VA Medical Center · Portland, United States · NIH-11373814

• Facilitating Shared Decision Making for Lung Cancer Screening

  A doctor-led project to help patients and their primary care providers make informed choices about lung cancer screening using easy-to-use information and technology.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11370889

• Understanding lung cancer screening use and outcomes in diverse populations

  A study looking at how newly expanded lung cancer screening guidelines are used in real-world settings and what outcomes occur for people from different populations.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11362151

• Provider Support and Patient Outreach in Lung Cancer Screening

  A multi-site study will test ways to help doctors and patients work together to make shared decisions and increase lung cancer screening in primary care.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11360715

• Lung Cancer Screening: How False Positives Impact Patients Over Time

  This project studies how often false positives happen in lung cancer screening and how they affect patients, clinicians, and healthcare systems.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11357614

• Lung cancer screening in the real world: finding true benefits and harms for patients

  This project looks at how low-dose CT screening for lung cancer works in everyday healthcare, beyond clinical trial settings, to understand who benefits and who could be harmed.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11357581

• Increase lung cancer screening uptake among high-risk emergency department patients

  A program tests a simple, low-cost plan using text reminders and easier referrals to help high-risk people visiting the emergency department start lung cancer screening with a low-dose CT scan.

  NIH research University of Rochester · Rochester, United States · NIH-11335266

• Improved Lung Cancer Screening for People Living with HIV

  A new plan to find the best way to screen for lung cancer in people living with HIV so they can be diagnosed earlier when treatment is more likely to help.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11328395

• Why some people get low-dose CT lung screening and others don't

  This project looks at reasons people with a smoking history do or don't receive low-dose CT lung cancer screening.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11323459

• Telehealth shared decision coaching for lung cancer screening

  This program uses telehealth decision coaching and patient navigation to help adults who are eligible for low‑dose CT lung cancer screening make informed choices and complete follow-up care.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11311265

• Smoking-cessation support for people getting lung cancer screening at MedStar Health

  This project compares two ways to help people who smoke quit when they come for lung cancer screening.

  NIH research Georgetown University · Washington, United States · NIH-11306567

• Personalized lung cancer risk tool to boost screening and help people quit smoking

  This project uses a personalized risk profile to help current and former smokers—particularly underserved and African American patients—get lung cancer screening and stop smoking.

  NIH research Washington University · Saint Louis, United States · NIH-11303257

• Blood-based test to better target lung cancer screening

  This project uses DNA changes in white blood cells from blood tests to help identify which older current or former smokers should get low-dose CT lung screening.

  NIH research Tufts University Boston · Boston, United States · NIH-11285180

• What's keeping people from getting lung cancer screening

  This project looks at why eligible adults—especially people from minority or low-income groups—don't get recommended low-dose CT lung cancer screening.

  NIH research Kaiser Foundation Research Institute · Oakland, UNITED STATES · NIH-11252562

• Personalized lung cancer screening and diagnosis for Veterans

  This project combines AI and blood-based biomarkers to better find and diagnose lung cancer in Veterans with a smoking history or military exposures.

  NIH research Veterans Health Administration · Nashville, United States · NIH-11195534

• Improving Lung Cancer Screening for Tribal Communities in Oklahoma

  This project aims to make lung cancer screening more accessible and effective for American Indian and Alaska Native people living in rural Oklahoma.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11194491

• Choosing the best way to pick people for lung cancer screening

  This project compares three ways of deciding who should get low-dose CT scans so more high-risk people are found early while using health care resources wisely.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11193965

• Digital tools to increase lung cancer screening at free community clinics

  This project will use digital outreach and a centralized hub to help people who smoke at free clinics get yearly low-dose CT lung cancer screening.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11186962

• Using lung cancer CT scans to find and help people with COPD

  This project uses low-dose CT images from lung cancer screening to spot signs of COPD in older current or former smokers so more people with undiagnosed COPD get follow-up breathing tests.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11179194

• Making it easier to keep up with yearly low‑dose lung CT screening

  This project creates low‑burden reminder messages and clinic-friendly approaches to help people at high risk stick with annual low‑dose CT lung cancer screening.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11175404

• An at-home cheek swab test for early lung cancer detection

  This project aims to create an easy at-home cheek swab test that can find early signs of lung cancer, especially for people who might not qualify for traditional CT scans.

  NIH research Northwestern University · Chicago, UNITED STATES · NIH-11168931

• Using social media to boost lung cancer screening in high-risk older adults

  This project uses targeted social media messages and tailored decision support to help older adults at higher risk learn about and choose lung cancer screening.

  NIH research Hackensack University Medical Center · Hackensack, United States · NIH-11167562

• Blood protein panel to improve lung cancer screening and biopsy decisions

  Looks at whether a blood test that measures specific proteins can help decide who should start lung cancer screening and when a lung nodule needs a biopsy, mainly for current and former smokers.

  NIH research International Agency for Res on Cancer · Lyon, France · NIH-11164575

• Trusted ways to increase lung cancer screening

  This project will try patient- and clinic-level strategies to help people eligible for low-dose CT get lung cancer screening.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11143706

• Understanding False Alarms in Lung Cancer Screening

  This project looks at how often false alarms happen in lung cancer screening and how they affect patients, doctors, and healthcare systems.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11141221

• Safer follow-up for small lung nodules found on CT scans

  This project compares smarter follow-up plans for people who have small spots (nodules) found on lung cancer screening CT scans.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11140352

Related topics

Quick answers

How many Lung Cancer Screening clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (12 trials), France (1 trial), Italy (1 trial), Norway (1 trial), Belgium (1 trial). Each study page lists its sites and which ones are recruiting.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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