Screening for bladder cancer using urine tests
Optimal Screening Strategy for Bladder Cancer in at Risk Patients
This study is testing if regular urine tests every six months can help catch bladder cancer earlier in people over 50 who are at high risk.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 1000 (estimated) |
| Ages | 50 Years and up |
| Sex | All |
| Sponsor | University of Texas Southwestern Medical Center Academic / other |
| Locations | 1 site (Dallas, Texas) |
| Trial ID | NCT05646485 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate the effectiveness of routine urine testing every six months for two years in detecting bladder cancer at an earlier stage among high-risk patients. Bladder cancer is often diagnosed at an advanced stage due to a lack of screening methods, and this trial seeks to fill that gap by utilizing urine molecular markers alongside traditional urinalysis. The study targets individuals over 50 years old with significant smoking history or occupational exposure, assessing whether early detection can improve outcomes. By identifying bladder cancer earlier, the study hopes to enhance treatment options and patient survival rates.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals aged 50 and older with a significant smoking history or occupational exposure linked to bladder cancer.
Not a fit: Patients with a prior history of bladder, kidney, or prostate cancer may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to earlier detection of bladder cancer, improving treatment outcomes and survival rates for patients.
How similar studies have performed: While bladder cancer screening is not widely established, similar approaches in other cancers have shown success, indicating potential for this novel method.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 50 * Smoking: ≥15 pack-year smoking history * Occupation:≥ 15 years of occupational exposures including: textile worker, painter, dry cleaners Exclusion Criteria: * Prior history of bladder, kidney, or prostate cancer * Prior evaluation of micro or gross hematuria within the last 2 years * Do not provide informed consent
Where this trial is running
Dallas, Texas
- University of Texas Southwestern Medical Center — Dallas, Texas, United States (Recruiting)
Study contacts
- Principal investigator: Yair Lotan, MD — University of Texas Southwestern Medical Center
- Study coordinator: Yair Lotan, MD
- Email: yair.lotan@UTsouthwestern.edu
- Phone: 214-648-0389
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.