Screening for bladder cancer using urine tests

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to evaluate the effectiveness of routine urine testing every six months for two years in detecting bladder cancer at an earlier stage among high-risk patients. Bladder cancer is often diagnosed at an advanced stage due to a lack of screening methods, and this trial seeks to fill that gap by utilizing urine molecular markers alongside traditional urinalysis. The study targets individuals over 50 years old with significant smoking history or occupational exposure, assessing whether early detection can improve outcomes. By identifying bladder cancer earlier, the study hopes to enhance treatment options and patient survival rates.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥ 50
* Smoking: ≥15 pack-year smoking history
* Occupation:≥ 15 years of occupational exposures including: textile worker, painter, dry cleaners

Exclusion Criteria:

* Prior history of bladder, kidney, or prostate cancer
* Prior evaluation of micro or gross hematuria within the last 2 years
* Do not provide informed consent

Where it's running

• University of Texas Southwestern Medical Center
  Dallas, Texas, United States Recruiting

Study contacts

• Principal investigator: Yair Lotan, MD — University of Texas Southwestern Medical Center
• Study coordinator: Yair Lotan, MD
• Email: yair.lotan@UTsouthwestern.edu
• Phone: 214-648-0389

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Reducing invasive tests for patients with blood in urine

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  Recruiting Erasmus Medical Center · Rotterdam · NCT06026189

• Bladder cancer: test a biomarker-guided plan after neoadjuvant therapy

  This phase 2 study tests a biomarker- and response-guided plan to preserve the bladder in patients with muscle-invasive bladder cancer after neoadjuvant therapy.

  Recruiting Phase 2 Fox Chase Cancer Center · Philadelphia, Pennsylvania · NCT07908979

• Specimen Collection for Validation of a New urine-based bladder cancer test

  This study collects urine and tumor samples from adults being evaluated or treated for urothelial cancer to validate a next‑generation sequencing platform.

  Recruiting Convergent Genomics, Inc. · Oceanside, California and 22 other locations · NCT07673016

• Dual-target Nectin-4 and HER2 CAR-NK therapy for advanced urothelial carcinoma

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  Recruiting Phase 1 Beijing Biotech · Shenzhen, Guangdong · NCT07492628

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.