CONNECT Multilingual: Helping Spanish and Cantonese Speakers Quit Smoking During Lung Cancer Screening
Official title: Evaluating the Impact of CONNECT, a Novel Smoking Cessation Intervention, in a Diverse, Multilingual Population
Run by University of California, San Francisco · NCT07111936 · Data updated 2026-11-12
This trial tests a multilingual version of the CONNECT program to help current adult smokers who speak Spanish or Cantonese quit smoking while undergoing lung cancer screening.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 50 Years to 80 Years |
| Sex | All |
| Enrollment | 439 (estimated) |
| Sponsor | University of California, San Francisco Academic / other |
| Locations | 1 site (San Francisco, California) |
| Status | Recruiting |
| Started | August 7, 2025 |
| Main results expected | March 31, 2028 |
| Study ends | March 31, 2028 |
| Registry record updated | August 13, 2026 |
| Trial ID | NCT07111936 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are California residents aged 50–80 who currently smoke (at least one cigarette in the past 7 days), have a ≥20 pack-year smoking history, and are eligible for lung cancer screening.
✕Probably not a fit
Smokers outside the target languages (Spanish/Cantonese) or those not meeting age, history, or screening eligibility criteria may not benefit from this program.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The study adapts the CONNECT smoking-cessation program for multilingual populations and tests its effectiveness in Spanish- and Cantonese-speaking adults aged 50–80 who are eligible for lung cancer screening. It includes focus groups, a beta pilot, then a randomized controlled trial with 400 participants across two arms: the multilingual CONNECT intervention versus standard care, with follow-ups at 1 week, 1 month, 3 months, and 6 months and a saliva test at 6 months to verify smoking status. The intervention combines a video doctor with personalized responses, texts, phone support, and pharmacist assistance for nicotine replacement therapy. The trial will measure smoking cessation rates and use of evidence-based quitting resources. The study is led by UCSF and collaborates with the Tobacco Related Disease Research Program and is conducted in California.
Why it matters
Potential benefit: If successful, the multilingual CONNECT program could improve quit rates among Spanish- and Cantonese-speaking smokers undergoing lung cancer screening.
How similar studies have gone: Prior CONNECT programs for LCS have shown promise, and this multilingual expansion builds on that approach, with mixed-language testing yet to be proven in a randomized setting.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age 50-80 years old. * Current smokers defined at smoking at least one cigarette in past 7 days AND eligible for lung cancer screening (LCS) based on smoking history (\>=20 pack year history) * California (CA) residents * Able to understand and comply with study procedures for the entire length of the study. * Ability of individual or legal guardian/representative to understand a written informed consent document, and the willingness to sign it. Exclusion Criteria: * Non-smokers. * Individuals with a diagnosis of lung cancer. * Individuals receiving hospice care. * Individuals whose providers do not think that they should participate (e.g., psychiatric illness or significant cognitive impairment that would impede the individuals ability to participate). * Hearing and/or vision disabilities that would prevent participants from adequately receiving treatment components such as video or telephone counseling.
Where it's running
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University of California San Francisco
San Francisco, California, United States Recruiting
Study contacts
- Principal investigator: Judith Walsh, MD, MPH — University of California, San Francisco
- Study coordinator: Anita Ponce, MSc
- Email: Anita.Ponce@ucsf.edu
- Phone: 415-502-1317
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.