Personalized treatment for smoking cessation in primary care
A Multilevel Intervention to Personalize and Improve Tobacco Treatment in Primary Care (MOTIVATE)
This study is testing a personalized approach to help people quit smoking in primary care to see if it works better than the usual methods.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 850 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Washington University School of Medicine Academic / other |
| Locations | 1 site (St Louis, Missouri) |
| Trial ID | NCT05846841 on ClinicalTrials.gov |
What this trial studies
This study evaluates a precision treatment intervention for smoking cessation, comparing its effectiveness to usual care in primary care settings. It utilizes personalized recommendations based on patients' clinical, genetic, and biomarker information to enhance treatment adherence and clinician prescribing practices. The study involves a 2-arm cluster randomized controlled trial with 50 clinicians and 800 eligible patients, aiming to assess the impact of precision treatment on smoking cessation success. The goal is to address gaps in both clinician and patient engagement with tobacco treatment.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18 and older who are current smokers and willing to consider medication for smoking cessation.
Not a fit: Patients who have recently used smoking cessation medications or have contraindications for such treatments may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly improve smoking cessation rates among patients by providing tailored treatment options.
How similar studies have performed: Other studies have shown promise in using precision medicine approaches for smoking cessation, indicating potential for success in this novel intervention.
Eligibility criteria
Show full inclusion / exclusion criteria
Eligibility Criteria for Primary and Specialty Care Clinicians * Clinician from participating clinic * At least 18 years of age * Can speak and understand English Eligibility Criteria for Primary Care and Specialty Patients Inclusion: * Patient at participating clinic * Age 18 years or older, inclusive * Current smoking (cigarettes per day \>=5) * Can speak and understand English * Willing to consider medication to help reduce craving or smoking such as nicotine patch, lozenge, or varenicline Exclusion: * Active use of smoking cessation medication (within the past 30 days) * Receipt of smoking cessation medication or prescription for smoking cessation medication (within the past 30 days) * Having a contraindication for cNRT or varenicline (allergic reactions, current cardiac problems, pregnancy)
Where this trial is running
St Louis, Missouri
- Washington University School of Medicine — St Louis, Missouri, United States (Recruiting)
Study contacts
- Principal investigator: Li-Shiun Chen, ScD, MD, MPH — Washington University School of Medicine
- Study coordinator: Li-Shiun Chen, ScD, MD, MPH
- Email: li-shiun@wustl.edu
- Phone: 314-362-3932
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.