Helping Cambodian people with HIV quit smoking using text messages
Official title: Ending Tobacco Use Through Interactive Tailored Messaging for Cambodian People Living With HIV/AIDS (Project END-IT)
Run by H. Lee Moffitt Cancer Center and Research Institute · NCT05746442 · Data updated 2026-11-12
This study is testing if sending text messages can help people in Cambodia who have HIV quit smoking by providing support and resources.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 800 (estimated) |
| Sponsor | H. Lee Moffitt Cancer Center and Research Institute Academic / other |
| Locations | 3 sites (Phnom Penh and 2 other locations) |
| Status | Recruiting |
| Started | January 11, 2023 |
| Main results expected | August 31, 2027 |
| Study ends | September 30, 2027 |
| Registry record updated | August 13, 2026 |
| Trial ID | NCT05746442 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are Cambodian adults aged 18 and older who are HIV-positive and currently smoke cigarettes.
✕Probably not a fit
Patients who have medical conditions preventing the use of nicotine replacement therapy or are currently enrolled in other cessation programs may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to evaluate the effectiveness of an automated text messaging program designed to assist HIV-positive smokers in quitting smoking. Participants will receive tailored messages, nicotine patches, and self-help materials to support their cessation efforts. The program encourages participants to set a quit date within two weeks of enrollment and provides ongoing support through smartphone technology. The study is conducted in collaboration with prominent institutions in Cambodia.
Why it matters
Potential benefit: If successful, this program could significantly improve smoking cessation rates among HIV-positive individuals, enhancing their overall health and quality of life.
How similar studies have gone: Other studies have shown success with text messaging interventions for smoking cessation, indicating a promising approach for this population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 1\) being aged ≥18 years * 2\) being HIV-positive * 3\) self-reporting as a current combustible cigarette smoker (smoked ≥100 cigarettes in lifetime and currently smoke ≥1 cigarettes/day) * 4\) willing to set a date for a quit attempt within 2 weeks of study enrollment * 5\) being able to provide written informed consent to participate * 6\) being able to read Khmer (score ≥4 points on the Rapid Estimate of Adult Literacy in Medicine-Short Form Exclusion Criteria: * 1\) history of a medical condition that precludes use of nicotine replacement therapy * 2\) physician/clinician deemed ineligible to participate based on medical or psychiatric condition * 3\) enrolled in another cessation program or use of other cessation medications.
Where it's running
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National AIDS Authority
Phnom Penh, Cambodia Recruiting -
National Center for HIV/AIDS, Dermatology and STD
Phnom Penh, Cambodia Recruiting -
National Institute of Public Health
Phnom Penh, Cambodia Recruiting
Study contacts
- Principal investigator: Damon Vidrine, Dr.PH — Moffitt Cancer Center
- Study coordinator: Lindsey Sparrock, PhD
- Email: Lindsey.Sparrock@moffitt.org
- Phone: 813-745-2893
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Proactive pharmacist e-consults to optimize lung health for people with HIV
This trial tests whether proactive pharmacist-led e-consults can help people with HIV improve lung-health medications, vaccinations, smoking cessation, and deprescribing of certain inhaled medicines or PPIs.
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Quitting Matters: a smoking quit program for people living with HIV
This 6-month program will test whether a tailored smartphone app plus nicotine patches and gum helps people living with HIV quit smoking better than a standard quit app.
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Optimizing smoking cessation treatments for people with HIV in South Africa
This study is testing a new way to help people with HIV in South Africa quit smoking by using a combination of counseling, support from peers, and medications to see if it works better than what’s currently available.
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Personalized wellness intervention for smoking cessation in adults living with HIV
This study tests a personalized program to help adults with HIV quit smoking and see if it works better than standard methods.
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Smoky Futures: Danish Adolescent Nicotine Use over Time
This observational cohort follows Danish youths ages 15–25 to see how cigarette, e-cigarette, and other nicotine use begin, change, and affect health and education over several years.
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Nicotine Orodispersible Tablet to Relieve Cravings in Smokers
A nicotine mint orodispersible tablet is tested vs placebo to see if it quickly eases the urge to smoke in adult cigarette smokers.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.