Condition

Tobacco Use Disorder clinical trials and research

• 28Clinical trials
• 9NIH research projects
• 7Countries

Newest Tobacco Use Disorder clinical trials

All recruiting trials (28)

• Personalized brain-targeted TMS for smoking cessation

  A personalized brain-guided Transcranial Magnetic Stimulation (TMS) approach is tested against a standard TMS method to see if it better changes reward brain activity and reduces cravings and smoking in adults with tobacco use disorder.

  Recruiting Rutgers, The State University of New Jersey · Newark, New Jersey · NCT07812753

• Multilevel program to increase LDCT lung cancer screening and help African American smokers quit

  This program will try combining low-dose CT screening with culturally tailored smoking-cessation support to help African American smokers who are eligible for LDCT quit and get screened.

  Recruiting at 2 sites Louisiana State University Health Sciences Center in New Orleans · New Orleans, Louisiana and 1 other locations · NCT07576595

• TUBSIS 2.0 — an online program to help adults reduce or quit smoking and vaping

  This program tests whether a free, anonymous, 4-week web-based course using mindfulness, self-compassion, and behavior-change techniques helps German-, English-, and Turkish-speaking adults who smoke or vape reduce or quit tobacco.

  Recruiting University of Zurich · Zurich · NCT07568483

• Impact of Menthol vs. Non-Menthol Cigarettes on Abuse Liability

  This study tests whether menthol cigarettes have different abuse potential than non-menthol cigarettes in menthol cigarette users, using a within-subject design across lab sessions and daily diaries.

  Recruiting Ohio State University Comprehensive Cancer Center · Columbus, Ohio · NCT07564648

• Ear acupressure plus nicotine replacement to ease withdrawal in psychiatric inpatients

  This study will test whether adding ear acupressure (ear seeds) to standard nicotine replacement therapy helps psychiatric inpatients who must stop smoking reduce withdrawal symptoms, cravings, and anxiety.

  Recruiting TsaoTun Psychiatric Center, Department of Health, Taiwan · Nantou City · NCT07466875

• Facilitating Tobacco Treatment in Veterans with Serious Mental Illness

  This project tests an external facilitation approach to help VA clinics prescribe smoking medications more often to Veterans with serious mental illness who smoke.

  Recruiting VA Office of Research and Development · Baltimore, Maryland · NCT07455526

• Cue-based treatment to help light and non-daily smokers quit

  A remote cue-based therapy added to standard smoking cessation coaching is being tested to see if it helps people who smoke lightly or intermittently quit.

  Recruiting Duke University · Durham, North Carolina · NCT07425119

• Accelerated bilateral deep TMS to help adults quit smoking

  This will try a 5-day course of bilateral accelerated deep transcranial magnetic stimulation to help adults with tobacco use disorder quit smoking.

  Recruiting Phase 2 Waypoint Centre for Mental Health Care · Penetanguishene, Ontario and 1 other locations · NCT07292883

• E-cigarette Cessation for Hispanic/Latino Teens in Florida

  This project tests a six-session, CBT-based e-cigarette cessation program tailored for Hispanic/Latino high school students to see if it helps reduce vaping use.

  Recruiting Florida International University · Miami, Florida · NCT07192601

• Varenicline-based approach to help Veterans who smoke see if they can reduce smoking and try to quit

  This study tests whether varenicline, plus motivational support, helps Veterans who aren’t ready to quit reduce smoking and make quit attempts.

  Recruiting at 3 sites Phase 4 VA Office of Research and Development · San Diego, California and 3 other locations · NCT06966362

• Education program for quitting smoking

  This study is testing an education program to help people with mental health disorders who smoke to quit by providing support from nurses.

  Recruiting Erzurum Technical University · Erzurum, Erzurum · NCT06930547

• Treatment for quitting cigarettes and reducing cannabis use

  This study tests if a medication called varenicline can help adults who smoke cigarettes and use cannabis quit smoking and cut down on cannabis use, with support from counseling and online resources.

  Recruiting Phase 3 Medical University of South Carolina · Charleston, South Carolina · NCT06883162

• tDCS plus varenicline to help people quit smoking

  This will test if adding noninvasive tDCS brain stimulation to varenicline helps adults who smoke at least 8 cigarettes a day quit and stay smoke-free.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06798324

• Helping adults quit e-cigarettes while using cannabis

  This study is testing if a medication, along with financial rewards and counseling, can help adults aged 18-40 quit e-cigarettes while they also use cannabis.

  Recruiting at 3 sites Phase 4 Medical University of South Carolina · Charleston, South Carolina and 2 other locations · NCT06688539

• Mobile smoking cessation program for Veterans undergoing surgery

  This study is testing a mobile program to help Veterans quit smoking before surgery by offering rewards for staying smoke-free.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06678672

• Effects of Cytisinicline on Smoking Cues in Daily Smokers

  This study tests if a medication called cytisinicline can help daily smokers reduce their cravings and reactions to cigarette-related triggers.

  Recruiting Phase 2 University of California, Los Angeles · Los Angeles, California · NCT06617312

• Reducing nicotine levels in cigarettes and e-cigarettes for dual users

  This study tests if lowering nicotine levels in cigarettes and e-cigarettes can help people who use both cut down on their tobacco use and cravings.

  Recruiting at 2 sites Phase 2 University of Vermont · Providence, Rhode Island and 1 other locations · NCT06614504

• Deep TMS to help adults with psychiatric conditions quit smoking

  This project will test whether deep transcranial magnetic stimulation (dTMS) helps adults with psychiatric disorders quit smoking better than usual nicotine replacement and counseling.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06534047

• Helping Veterans quit smoking during cancer care

  This study is testing a new program to help Veterans quit smoking while they are being screened or treated for lung cancer.

  Recruiting VA Office of Research and Development · San Francisco, California · NCT06432985

• Using focused ultrasound to reduce cravings in smokers

  This study is testing if a new ultrasound treatment can help reduce cravings for cigarettes in people trying to quit smoking.

  Recruiting Washington D.C. Veterans Affairs Medical Center · Washington D.C., District of Columbia · NCT06405074

• Understanding tobacco and cannabis use among young adults

  This study looks at how using cannabis affects young adults aged 18-25 who are trying to quit tobacco, while they receive support for their quit attempt over 12 weeks.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06239350

• Using cannabidiol to help reduce cigarette smoking

  This study is testing if taking cannabidiol (CBD) can help people who want to quit smoking cigarettes reduce their tobacco use.

  Recruiting Phase 2 University of California, Los Angeles · North Hollywood, California · NCT06218056

• Mindfulness meditation in virtual reality to help stop smoking

  This study is testing if mindfulness meditation in virtual reality can help people who want to quit smoking by reducing cravings and preventing them from going back to smoking.

  Recruiting at 3 sites Centre Hospitalier Henri Laborit · Iteuil and 2 other locations · NCT05766553

• Improving smoking cessation success through sleep and chess training

  This study is testing whether combining chess training and better sleep can help people quit smoking more successfully.

  Recruiting Central Institute of Mental Health, Mannheim · Mannheim, Baden-Wurttemberg · NCT05726045

• Using brain stimulation to help veterans quit smoking

  This study is testing a new way to help veterans with PTSD quit smoking by combining counseling, nicotine replacement, and brain stimulation to see if it works better for them.

  Recruiting Phase 2 VA Office of Research and Development · Durham, North Carolina · NCT05723588

• Investigating the effects of propranolol and nicotine patches on smoking cues

  This study is testing whether taking propranolol and using nicotine patches can help daily smokers resist the urge to smoke when they see things that remind them of smoking.

  Recruiting Phase 4 University of Oklahoma · Tulsa, Oklahoma · NCT05587361

• Using psilocybin to help people quit smoking

  This study is testing if psilocybin can help daily smokers who have struggled to quit in the past to finally stop smoking, using it alongside therapy.

  Recruiting Phase 2 Johns Hopkins University · Birmingham, Alabama and 2 other locations · NCT05452772

• Using Cannabidiol to Help People Quit Smoking

  This study is testing if taking cannabidiol (CBD) can help people who smoke more than 10 cigarettes a day quit smoking and feel better during withdrawal.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT05445804

NIH-funded research (9)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• VR-based attentional bias as a biomarker for tobacco use disorder

  A study at UC San Diego is testing a virtual reality task to see if attentional bias can serve as a biomarker to help treat cigarette addiction.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11350932

• Community health worker support to help people with serious mental illness quit smoking

  This project trains Medicaid behavioral health staff to act as community health workers who help adults with serious mental illness stop using tobacco.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11225257

• Smoking-cessation meds with a team approach for people with HIV (SMARTTT)

  A multi-site study tests a team-based plan using medication and rewards to help people with HIV quit smoking.

  NIH research Yale University · New Haven, United States · NIH-11169520

• Using virtual reality to understand how attention affects tobacco addiction

  This study is looking at how daily tobacco users react to virtual reality situations that remind them of smoking, to see if their attention to these cues can help predict how well they might do with quitting smoking, especially when using a medication called varenicline compared to a placebo.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11164800

• A program to help individuals with bipolar disorder reduce tobacco use through future thinking.

  This study is testing a new program called 'Future Self-BD' to help people with bipolar disorder who want to quit smoking by imagining positive future outcomes from stopping, and it aims to see how well the program works and if it's easy to use.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11077784

• Using focused ultrasound to help people quit smoking

  This study is looking at a new, gentle ultrasound treatment that might help people who want to quit smoking by reducing their cravings for cigarettes, and it's designed for anyone struggling with tobacco use.

  NIH research U.s. Dept/vets Affairs Medical Center · Washington, United States · NIH-11070401

• Improving health outcomes for people with opioid and tobacco use disorders

  This study is all about finding better ways to help people who are dealing with opioid and tobacco addiction, while also training new researchers from diverse backgrounds to make sure their work really helps those in need.

  NIH research Albert Einstein College of Medicine · Bronx, United States · NIH-11060946

• A new method to help people with HIV quit smoking

  This study is looking at a new way to help people with HIV who want to quit smoking by trying different treatments based on how they respond, so if you're living with HIV and want to stop using tobacco, this research might be for you!

  NIH research Yale University · New Haven, United States · NIH-10893629

• Using psilocybin to help people quit smoking

  This study is looking at whether taking psilocybin, along with cognitive behavior therapy, can help people quit smoking better than using nicotine patches with the same therapy, and it's open to a diverse group of participants who will be paid for their time.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10669236

Related topics

Quick answers

How many Tobacco Use Disorder clinical trials are recruiting right now?

28, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (20 trials), Canada (3 trials), Taiwan (1 trial), Turkey (Türkiye) (1 trial), France (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 4: 5, Phase 3: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →