NIH-funded research NIH-funded research

Social stress and smoking: why disadvantaged young adults struggle to quit

Official title: The Impact of Social-Contextual Stressors on Psychopharmacological Mechanisms of Smoking Cessation and Relapse among Socioeconomically Disadvantaged Young Adults who Smoke Cigarettes

Funded at Medical University of South Carolina · NIH-11540695 · Data updated 2026-11-12

This grant looks at how daily social stress affects if and when disadvantaged young adults who smoke can quit and stay quit.

More Smoking research and trials

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionMedical University of South Carolina
NIH-funded
Lab location1 site (Charleston, United States)
Project startJune 1, 2026
Project endMay 31, 2029
Funding year2026
Award (this year)$249,000
NIH project number4R00DA060983-02
Project IDNIH-11540695 on NIH RePORTER

Who could benefit from this research

Could help

Ideal participants are socioeconomically disadvantaged young adults who smoke cigarettes and are transitioning into young adulthood.

Less likely to help

Some participants may not experience immediate benefit if stressors do not disrupt their quit attempts.

What this research studies

The project focuses on socioeconomically disadvantaged young adults who smoke and follows their real-life experiences to see how daily stressors influence quitting and relapse. It combines interviews about lived experiences with real-time data collection to capture day-to-day changes in stress. By linking social-contextual factors to smoking behavior, it aims to identify moments when support could help a quit attempt succeed. The study is led by the Medical University of South Carolina and centers on participants’ everyday lives in real-world settings.

Why it matters

Potential benefit: If successful, findings could inform tailored supports that help SDYA quit smoking and reduce relapse.

How similar studies have gone: Prior research shows social factors influence smoking behavior, but real-time EMA approaches in this population are newer and promising.

Where this research is happening

  • Medical University of South Carolina
    Charleston, United States
    Active

Researchers

  • Principal investigator: Bello, Mariel Seanne Mercado — Medical University of South Carolina
  • Study coordinator: Bello, Mariel Seanne Mercado

Related research

Other NIH-funded projects on the same topics.

  • Adaptive treatment for early smoking relapse in adults

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    NIH research Medical University of South Carolina · Charleston, United States · NIH-11362332

  • Helping people quit smoking for good

    This project helps daily smokers find the best way to quit cigarettes, especially if their first attempt isn't successful.

    NIH research Medical University of South Carolina · Charleston, United States · NIH-11121737

  • How social stress affects young adults' ability to quit smoking

    This study looks at how everyday stress from money and social situations makes it harder for young adults with limited resources to quit smoking and stay smoke-free, so we can better understand their challenges and help them succeed in quitting.

    NIH research Brown University · Providence, United States · NIH-10949742

  • Testing new ways to help smokers quit by changing treatments

    This study is looking at whether changing smoking cessation medications or trying e-cigarettes can help people who have had a hard time quitting smoking finally succeed, and you'll get support and a month’s supply of medication to help you set a quit date.

    NIH research Medical University of South Carolina · Charleston, United States · NIH-10875543

  • I-STOP: a mobile health program to help people with HIV quit smoking

    A smartphone-based program designed to help people with HIV quit smoking in a sustainable, affordable way.

    NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-11535367

  • Smoking cessation help for people with HIV in South Africa

    A program is being tested to help people living with HIV in South Africa quit smoking in ways that fit low-resource clinics and show good value.

    NIH research Johns Hopkins University · Baltimore, United States · NIH-11535332

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.