Condition

Nicotine Dependence clinical trials and research

• 29Clinical trials
• 4NIH research projects
• 7Countries

Newest Nicotine Dependence clinical trials

All recruiting trials (29)

• How people puff IQOS Iluma i vs IQOS 2.4 and how flavors feel

  This study tests how exclusive IQOS users puff the newer Iluma i versus the older 2.4, and whether preferred flavor affects puffing and sensory experience.

  Recruiting at 2 sites American University of Beirut Medical Center · Beirut, Beirut and 1 other locations · NCT07712887

• Do a single nicotine pouch affect cigarette craving and brain response to smoking cues

  This study tests whether a single 6 mg oral nicotine pouch can reduce craving and alter prefrontal brain responses to smoking cues in adults who smoke cigarettes.

  Recruiting University of Southern California · Los Angeles, California · NCT07698470

• TUBSIS 2.0 — an online program to help adults reduce or quit smoking and vaping

  This program tests whether a free, anonymous, 4-week web-based course using mindfulness, self-compassion, and behavior-change techniques helps German-, English-, and Turkish-speaking adults who smoke or vape reduce or quit tobacco.

  Recruiting University of Zurich · Zurich · NCT07568483

• Social media support groups to help teens and young adults quit vaping

  This pilot tries a social-media group program called the Quit the Hit Toolkit to help adolescents and young adults who vape stop using nicotine.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07540780

• Ear acupressure plus nicotine replacement to ease withdrawal in psychiatric inpatients

  This study will test whether adding ear acupressure (ear seeds) to standard nicotine replacement therapy helps psychiatric inpatients who must stop smoking reduce withdrawal symptoms, cravings, and anxiety.

  Recruiting TsaoTun Psychiatric Center, Department of Health, Taiwan · Nantou City · NCT07466875

• Sex differences in how menthol e-cigarettes appeal to people who smoke

  This study tests whether men and women differ in how menthol e-cigarettes with or without nicotine appeal to smokers who have used e-cigarettes before.

  Recruiting Yale University · New Haven, Connecticut · NCT07398976

• Perioperative high-dose nicotine patch for pain sensitivity in male smokers undergoing thoracic surgery

  We will try a high-dose nicotine patch around the time of surgery to see if it reduces pain sensitivity in adult male smokers having thoracoscopic lung surgery.

  Recruiting Henan Provincial People's Hospital · Zhengzhou, Henan · NCT07250230

• Varenicline plus enhanced TMS to help adults quit smoking and vaping

  This study tests whether adding active enhanced accelerated transcranial magnetic stimulation (aTMS) to varenicline helps adults 18–65 quit nicotine use more effectively than varenicline with sham stimulation.

  Recruiting Phase 4 Massachusetts General Hospital · Boston, Massachusetts · NCT07145866

• Varenicline to help adults stop vaping

  This trial tests whether the smoking-cessation pill varenicline helps adults who vape daily quit e-cigarettes.

  Recruiting at 2 sites Phase 2 Yale University · New Haven, Connecticut and 1 other locations · NCT07040566

• Smart smell app to help adults stop smoking

  This project will test whether adding a smell-based device to a smartphone quit-smoking app helps adults who smoke reduce cravings and stay quit.

  Recruiting Early Phase 1 University of Houston · Houston, Texas · NCT07007195

• Cannabidiol (CBD) for reducing stress and nicotine withdrawal in daily cigarette smokers.

  This trial tests whether a single dose of CBD can reduce stress responses and nicotine withdrawal symptoms in adults who smoke cigarettes daily.

  Recruiting Phase 1 Johns Hopkins University · Baltimore, Maryland · NCT07001930

• Digital tool to help young adults quit vaping with ACT on Vaping app

  A smartphone app using Acceptance and Commitment Therapy is tested to see if it helps 18-30 year-olds quit vaping, compared to a version with enhanced text support.

  Recruiting Fred Hutchinson Cancer Center · Seattle, Washington · NCT06909500

• tDCS plus varenicline to help people quit smoking

  This will test if adding noninvasive tDCS brain stimulation to varenicline helps adults who smoke at least 8 cigarettes a day quit and stay smoke-free.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06798324

• QuitVaping behavioral program with texting support to help teens stop vaping

  This trial will try QuitVaping plus extra texting to see if it helps teens aged 14–18 who vape nicotine quit more than standard education and referral alone.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT06765291

• Helping adults quit e-cigarettes while using cannabis

  This study is testing if a medication, along with financial rewards and counseling, can help adults aged 18-40 quit e-cigarettes while they also use cannabis.

  Recruiting at 3 sites Phase 4 Medical University of South Carolina · Charleston, South Carolina and 2 other locations · NCT06688539

• Evaluating nicotine pouches for quitting smoking

  This study is testing if tobacco-free nicotine pouches can help smokers switch from cigarettes by trying out different nicotine levels over 28 days.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06678789

• Adapting a Skills-Based Smoking Cessation Program for Gender-Diverse Adults Under Stress

  A skills-based smoking cessation program is being adapted and tested to see if it helps gender-diverse adults who smoke, especially when stressed by gender-related factors and mood problems.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts and 2 other locations · NCT06654414

• Deep TMS to help adults with psychiatric conditions quit smoking

  This project will test whether deep transcranial magnetic stimulation (dTMS) helps adults with psychiatric disorders quit smoking better than usual nicotine replacement and counseling.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT06534047

• Exploring the appeal and risks of oral nicotine products among young adult e-cigarette users

  This study looks at how appealing and risky new oral nicotine products are for young adults who only use e-cigarettes to see how flavors and nicotine levels affect their choices.

  Recruiting at 2 sites University of Southern California · Los Angeles, California and 1 other locations · NCT06506162

• Understanding tobacco and cannabis use among young adults

  This study looks at how using cannabis affects young adults aged 18-25 who are trying to quit tobacco, while they receive support for their quit attempt over 12 weeks.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT06239350

• Comparing e-cigarettes and nicotine pouches for reducing cigarette smoking

  This study is testing whether e-cigarettes or nicotine pouches help adult smokers cut down on their cigarette use over four weeks.

  Recruiting Yale University · New Haven, Connecticut · NCT06077240

• Community-based smoking cessation program for adults with high stress sensitivity

  This study is testing a personalized smoking cessation program that includes counseling and exercise to see if it helps adults with high anxiety sensitivity quit smoking more effectively.

  Recruiting Phase 3 University of Texas at Austin · Austin, Texas · NCT06053567

• Comparing different forms of nicotine in vaping

  This study is testing how different types of nicotine in vaping affect experienced users' cravings, withdrawal symptoms, and enjoyment while also looking at how their bodies process these forms of nicotine.

  Recruiting Phase 1 University of California, San Francisco · San Francisco, California · NCT05962229

• Switching from cigarettes to heated tobacco products and its effects on heart disease

  This study is testing whether switching from regular cigarettes to heated tobacco products can help people with heart disease reduce the damage to their arteries.

  Recruiting National Institute of Cardiology, Warsaw, Poland · Warsaw · NCT05660798

• Exploring the role of orexin in treating nicotine dependence

  This study tests if a medication called suvorexant can help people who are trying to quit smoking by looking at how it affects their brain and behavior.

  Recruiting National Institutes of Health Clinical Center (CC) · Baltimore, Maryland · NCT05630781

• Investigating the effects of propranolol and nicotine patches on smoking cues

  This study is testing whether taking propranolol and using nicotine patches can help daily smokers resist the urge to smoke when they see things that remind them of smoking.

  Recruiting Phase 4 University of Oklahoma · Tulsa, Oklahoma · NCT05587361

• Impact of Menstrual Cycle Phase on Smoking Cessation

  This study tests if starting smoking cessation treatment during certain phases of the menstrual cycle helps women quit smoking more successfully.

  Recruiting Phase 4 Centre for Addiction and Mental Health · Toronto, Ontario · NCT05515354

• Helping smokers practice quitting tobacco

  This study is testing a new way to help smokers practice quitting tobacco by trying short breaks from smoking without pressure, comparing it to regular counseling, to see which method helps them make more quit attempts over six months.

  Recruiting Phase 1/2 Rush University Medical Center · Chicago, Illinois · NCT05513872

• Advanced MRI techniques for studying drug addiction

  This study is testing new MRI techniques to see how drug addiction affects the brain by comparing healthy people with those who use drugs.

  Recruiting National Institutes of Health Clinical Center (CC) · Baltimore, Maryland · NCT01036581

NIH-funded research (4)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Interpeduncular brain circuit links stress and nicotine use

  A study in rodents will explore how a specific brain circuit (IPN) that reacts to stress may influence nicotine intake and anxiety related to nicotine withdrawal.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11357563

• How a brain area connects stress and nicotine cravings

  This research explores how a specific part of the brain links stress to nicotine dependence and withdrawal anxiety.

  NIH research Univ of Massachusetts Med Sch Worcester · Worcester, United States · NIH-11120884

• Understanding how the brain's insular cortex affects nicotine addiction

  This study is looking at how a specific part of the brain helps mice that are addicted to nicotine feel cravings and withdrawal, which could help us understand addiction better and find ways to reduce the urge to smoke.

  NIH research Harvard Medical School · Boston, United States · NIH-11051187

• Targeting brain circuits to help people with schizophrenia quit smoking

  This study is looking at how certain brain areas related to nicotine cravings can be helped with a special treatment called brain stimulation, to make it easier for people with schizophrenia to quit smoking.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11014359

Related topics

Quick answers

How many Nicotine Dependence clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 7 countries. The most sites are in United States (21 trials), Canada (3 trials), Lebanon (1 trial), Taiwan (1 trial), China (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 6, Phase 1: 2, Early Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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