Smoking cessation support for people living with HIV in South Africa

Evaluating smoking cessation interventions for PWH in South Africa: Efficacy, implementation, and cost-effectiveness.

NIH-funded research Johns Hopkins University · NIH-11376842

Seeing if proven quit-smoking programs can help adults with HIV in South Africa stop smoking and lower their risk of TB, heart, and lung disease.

Quick facts

Grant typeU01 cooperative agreement
Study typeNIH-funded research
Funding institutionJohns Hopkins University NIH-funded
Lab location1 site (Baltimore, United States)
Project IDNIH-11376842 on NIH RePORTER

What this research studies

If you join, researchers will enroll adults living with HIV who currently smoke at participating HIV clinics in South Africa and offer proven quit-smoking programs adapted for local care settings. The team will compare different evidence-based approaches (behavioral counseling, medication support, and implementation strategies) to see which help people quit and can be delivered in routine clinics. They will track quitting using clinical follow-up and biochemical checks, study how the programs are put into practice at clinics, and measure costs to understand value for the health system. The goal is to find practical, affordable ways clinics can help people with HIV stop smoking and stay smoke-free.

Who could benefit from this research

Good fit: Adults living with HIV in South Africa who currently smoke tobacco and receive care at participating clinics are the ideal candidates.

Not a fit: People who do not smoke, who live outside the study regions, or who are unwilling to try the offered cessation treatments are unlikely to benefit directly from participation.

Why it matters

Potential benefit: If successful, this work could increase quit rates among people with HIV in South Africa and reduce smoking-related TB, cardiovascular, and lung disease.

How similar studies have performed: Similar evidence-based cessation programs have helped smokers in other low-resource settings, but tailored data among people with HIV in South Africa remain limited.

Where this research is happening

Baltimore, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Acquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome Virus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.