Smoking cessation support for people living with HIV in South Africa
Official title: Evaluating smoking cessation interventions for PWH in South Africa: Efficacy, implementation, and cost-effectiveness.
Funded at Johns Hopkins University · NIH-11376842 · Data updated 2026-11-12
Seeing if proven quit-smoking programs can help adults with HIV in South Africa stop smoking and lower their risk of TB, heart, and lung disease.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | September 15, 2021 |
| Project end | August 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $363,472 |
| NIH project number | 3U01CA261626-05S1 |
| Project ID | NIH-11376842 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults living with HIV in South Africa who currently smoke tobacco and receive care at participating clinics are the ideal candidates.
✕Less likely to help
People who do not smoke, who live outside the study regions, or who are unwilling to try the offered cessation treatments are unlikely to benefit directly from participation.
What this research studies
If you join, researchers will enroll adults living with HIV who currently smoke at participating HIV clinics in South Africa and offer proven quit-smoking programs adapted for local care settings. The team will compare different evidence-based approaches (behavioral counseling, medication support, and implementation strategies) to see which help people quit and can be delivered in routine clinics. They will track quitting using clinical follow-up and biochemical checks, study how the programs are put into practice at clinics, and measure costs to understand value for the health system. The goal is to find practical, affordable ways clinics can help people with HIV stop smoking and stay smoke-free.
Why it matters
Potential benefit: If successful, this work could increase quit rates among people with HIV in South Africa and reduce smoking-related TB, cardiovascular, and lung disease.
How similar studies have gone: Similar evidence-based cessation programs have helped smokers in other low-resource settings, but tailored data among people with HIV in South Africa remain limited.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Golub, Jonathan E. — Johns Hopkins University
- Study coordinator: Golub, Jonathan E.
Related research
Other NIH-funded projects on the same topics.
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Social stress and smoking: why disadvantaged young adults struggle to quit
This grant looks at how daily social stress affects if and when disadvantaged young adults who smoke can quit and stay quit.
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I-STOP: a mobile health program to help people with HIV quit smoking
A smartphone-based program designed to help people with HIV quit smoking in a sustainable, affordable way.
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Smoking cessation help for people with HIV in South Africa
A program is being tested to help people living with HIV in South Africa quit smoking in ways that fit low-resource clinics and show good value.
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Mobile tools to understand how sleep affects quitting smoking
This project uses a smartphone to track sleep and smoking in lower-income adults trying to quit to find how sleep patterns relate to staying smoke-free.
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Integrated approach to lung screening and quitting for African Americans
A multi-level program aims to boost LDCT lung cancer screening uptake and help African American smokers quit, with support from a comprehensive community-focused plan.
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Peer-led smoking-cessation program for public housing residents
A peer-led program with eight group sessions plus nicotine replacement therapy is tested on adults living in public housing to help them quit smoking.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.