Understanding brain changes in chronic pancreatitis pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Researchers will combine clinical profiling, blood metabolite analysis, and advanced brain imaging (resting-state fMRI and MR spectroscopy) to explore how central sensitization and brain dysfunction relate to pain in chronic pancreatitis. The study uses comprehensive neuropsychological testing alongside metabolic and imaging data to identify patterns that correlate with pain experiences. Participants are adults with CP who meet imaging-confirmed criteria, and results may help identify objective brain and blood markers of pain. The study is observational and takes place at the Asian Institute of Gastroenterology in Hyderabad, India.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosed with CP confirmed by CECT, MRCP, or EUS based on Cambridge or Rosemont criteria.
* Age 18-60 years.
* Both genders

Exclusion Criteria:

* Recent episode of acute pancreatitis or ongoing pain (VAS \>5).
* Pancreatic cancer and other significant comorbidities.
* Recent use of antidepressants, anxiolytics, high-potency opioids, or neuromodulators.
* Pregnancy and lactation.
* Inability to give informed consent.

Where it's running

• Asian Institute of Gastroenterology
  Hyderabad, Telangana, India Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.