Moderate-intensity aerobic and resistance exercise to reduce pain sensitization in breast cancer survivors
Moderate-Intensity Exercise and Pain Sensitization in Breast Cancer Survivors: A Case-Based Study
This program will try a supervised moderate-intensity aerobic plus resistance exercise regimen to see if it reduces pain sensitization and persistent upper-limb pain in breast cancer survivors.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 10 (estimated) |
| Sex | Female |
| Sponsor | Universidad Rey Juan Carlos Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Madrid) |
| Trial ID | NCT07128030 on ClinicalTrials.gov |
What this trial studies
This is a supervised, combined moderate-intensity aerobic and resistance training program aimed at reducing pain sensitization in women who completed treatment for stage I–III breast cancer at least six months earlier and who report persistent upper-quadrant pain. The primary goals are to test feasibility, safety, and acceptability of the exercise intervention. Secondary measures include changes in pain intensity, somatosensory sensitivity, and temporal summation using quantitative sensory testing, while tertiary outcomes track quality of life and functional capacity. The intervention is delivered at Universidad Rey Juan Carlos with clinical collaboration from Hospital General Universitario Gregorio Marañón in Madrid.
Who should consider this trial
Good fit: Adult women with stage I–III breast cancer who finished active treatment at least six months ago, have persistent upper-limb pain or altered sensation related to treatment, can perform moderate-intensity exercise, and can attend sessions in Madrid (Spanish speakers).
Not a fit: People unlikely to benefit include those with bilateral breast cancer, locoregional recurrence, other active malignancies, pre-existing non–treatment-related pain, neurological or cognitive disorders, contraindications to moderate exercise, or who cannot attend sessions or speak Spanish.
Why it matters
Potential benefit: If successful, the program could lower pain sensitization and chronic pain intensity, improving function and quality of life for breast cancer survivors.
How similar studies have performed: Previous exercise programs have shown improvements in pain, function, and quality of life for breast cancer survivors, but targeted interventions specifically focused on reducing pain sensitization and temporal summation are less well established.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult women diagnosed with stage I-III breast cancer * Completion of active treatment (surgery, chemotherapy, and/or radiotherapy) at least 6 months prior to enrollment * Presence of persistent pain or altered sensation in the upper quadrant of the affected limb related to oncologic treatment Exclusion Criteria: * Bilateral breast cancer * Locoregional recurrence * Other malignancies * Pre-existing pain not related to cancer treatment * Neurological or cognitive disorders * Non-Spanish speakers * Contraindications to moderate-intensity physical activity
Where this trial is running
Madrid
- Universidad Rey Juan Carlos — Madrid, Spain (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.