Compare submucosal dexamethasone versus methylprednisolone after parasymphysis mandible repair

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This Phase 2 interventional trial enrolls adults with isolated parasymphysis mandibular fractures less than one week old who undergo standard surgical repair. Participants receive a single submucosal injection of either dexamethasone or methylprednisolone at the surgical site, and postoperative outcomes such as pain (VAS), facial edema, and trismus are recorded over the early recovery period. The protocol excludes patients with immunocompromise, recent systemic steroid use, comminuted fractures, active odontogenic infection, or steroid hypersensitivity to reduce confounding. Results will be used to guide selection of perioperative corticosteroid therapy for this specific fracture type.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients aged 18 to 40.
2. Both Gender.
3. Fracture less than a week old.
4. Isolated mandibular parasymphysis fractures.

Exclusion Criteria:

* 1\. Immunocompromised patients (due to increased risk of infection and complications).

  2\. Patients experiencing acute pain from conditions such as pulpitis, abscesses, or other acute infections (to ensure that acute pain does not confound the study results).

  3\. Patients reporting hypersensitivity to steroids (to avoid adverse reactions).

  4\. Patients taking or requiring prophylactic antibiotics or anti-inflammatory drugs before surgery (to prevent confounding effects on study outcomes).

  5\. Patients with a history of systemic steroid administration for 15 days (as this could affect the study's outcomes).

  6\. Patients with chronic pain problems or mental disorders (to maintain consistency in response to treatment).

  7\. Patients with comminuted fractures (to maintain consistency in fracture type).

  8\. Pregnant or lactating women (to avoid potential risks to the fetus and nursing infant).

  9\. Smokers who smoke at least 10 cigarettes per day for 2 years (to minimize the impact of smoking on healing and recovery).

ria:

Where it's running

• Nishtar Institute of Dentistry Multan
  Multan, Punjab Province, Pakistan Recruiting

Study contacts

• Study coordinator: Ammar ali khalid, Bachelor of dental surgery
• Email: ammaraligoraya@gmail.com
• Phone: 923129216146

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.