Peripheral autonomic plus TAP blocks for pain after minimally invasive left-sided colorectal surgery
Official title: Peripheral Autonomic Block (BAP) Plus Transversus Abdominis Plane Block (TAP) for Postoperative Analgesia After Minimally Invasive Left-Sided Colorectal Resection (BAPTAP): A Randomized, Controlled, Double-Blind Trial
Run by Faculdade de Ciências Médicas de Minas Gerais · NCT07388953 · Data updated 2026-11-12
This will try adding a peripheral autonomic block (targeting the superior hypogastric and inferior mesenteric plexuses) plus a TAP block to standard pain control in adults having elective minimally invasive left-sided colorectal surgery to see if it reduces pain and opioid use in the first 48 hours.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 80 Years |
| Sex | All |
| Enrollment | 140 (estimated) |
| Sponsor | Faculdade de Ciências Médicas de Minas Gerais Academic / other |
| Locations | 1 site (Belo Horizonte, Minas Gerais) |
| Status | Recruiting |
| Started | February 12, 2026 |
| Main results expected | December 5, 2026 |
| Study ends | July 5, 2027 |
| Registry record updated | February 13, 2026 |
| Trial ID | NCT07388953 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with ASA I–II status scheduled for elective laparoscopic left-sided colorectal resection who can provide informed consent and do not have contraindications such as coagulation disorders or chronic opioid therapy are ideal candidates.
✕Probably not a fit
Patients on chronic opioid therapy, those with coagulation disorders, severe obesity (BMI >35 kg/m²), pregnancy, or known allergy to local anesthetics are unlikely to benefit or be eligible for this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized, double-blind, parallel-group trial will enroll 140 adults undergoing elective laparoscopic left-sided colorectal resection and randomly assign them 1:1 to either the combined peripheral autonomic plexus block plus bilateral ultrasound-guided transversus abdominis plane (TAP) block (BAPTAP) with standardized multimodal analgesia or to standard multimodal analgesia with trocar/wound infiltration. The autonomic component targets the superior hypogastric and inferior mesenteric plexuses to address visceral pain while the TAP block targets somatic abdominal wall pain. Primary outcomes are pain intensity on the Numerical Rating Scale at predefined time points and cumulative opioid consumption (IV morphine equivalents) in the first 48 hours after surgery. Participants, postoperative care teams, and outcome assessors are blinded; the anesthesiologist performing the block is not involved in postoperative assessments.
Why it matters
Potential benefit: If successful, the combined block approach could reduce postoperative pain and opioid use, shorten recovery milestones, and lower opioid-related side effects.
How similar studies have gone: Autonomic plexus blocks have shown promise in gynecologic and bariatric surgery and TAP blocks reduce somatic abdominal pain, but combining peripheral autonomic and TAP blocks for colorectal resection is relatively novel and not yet well established.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Elective laparoscopic left-sided colorectal resection * ASA physical status I-II * Ability to understand the study and sign informed consent Exclusion Criteria: * Known allergy to study medications (e.g., local anesthetics) * Coagulation disorders * Pregnancy * Inability to understand or provide consent * Chronic pain on opioid therapy * BMI \> 35 kg/m²
Where it's running
-
Santa Casa de Misericórdia de Belo Horizonte
Belo Horizonte, Minas Gerais, Brazil Recruiting
Study contacts
- Study coordinator: Matheus Mmmde Meyer, Md
- Email: matheusww@gmail.com
- Phone: 5531988044987
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Bowel Sounds and Day-to-Day Recovery After Colorectal Cancer Surgery
This study will test whether monitoring bowel sounds before and after colorectal cancer surgery can predict how quickly patients recover bowel function and resume eating.
-
Pre-emptive endoscopic vacuum therapy to reduce anastomotic leaks after colorectal cancer surgery
This will try using pre-emptive endoscopic vacuum therapy after colorectal cancer surgery to see if it lowers early anastomotic leaks in adults having radical colorectal operations.
-
Testing for leaks in colorectal surgery
This study is testing a new method to check for leaks during colorectal cancer surgery to see if it helps reduce complications after the operation.
-
Evaluating a new device to prevent stoma creation after colorectal surgery
This study is testing a new device to see if it can help prevent the need for a stoma after colorectal surgery in adults who are at risk of complications.
-
Knife-assisted full-thickness resection for rectal lesions in a multicenter setting
A multicenter study tests knife-assisted full-thickness resection (kFTR) to remove rectal lesions in adults and see how well it works and how safe it is.
-
Personalized 3D Bioprinted Colorectal Cancer Microenvironment Model
This study tests patient-derived, 3D-bioprinted cancer models that include tumor, fibroblast, and immune cells to see if they can better predict how colorectal cancer will respond to treatment.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.