Clinical trial Recruiting at 1 site Observational Ages 18 and up

Tracking early pain and recovery after a limb amputation

Official title: Early Postoperative Pain and Functional Recovery Following a Limb Amputation: a Retrospective Observational Study.

Run by Istituto Ortopedico Rizzoli · NCT07393139 · Data updated 2026-11-12

This project will look at early post‑operative pain and functional recovery in adults who had a limb amputation to see how pain changes and what factors are linked to better or worse recovery.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment150 (estimated)
SponsorIstituto Ortopedico Rizzoli
Academic / other
Locations1 site (Bologna)
StatusRecruiting
StartedJanuary 9, 2026
Main results expectedDecember 2026
Study endsDecember 2026
Registry record updatedNovember 4, 2026
Trial IDNCT07393139 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults (≥18 years) who had a first-time limb amputation at IRCCS Istituto Ortopedico Rizzoli during the study period and who do not have severe cognitive impairment or immediate post-op mortality/critical illness are the ideal candidates.

Probably not a fit

Patients with prior amputations, severe cognitive impairment or dementia, those who died or were critically ill within 48 hours, or those admitted for stump revision are unlikely to benefit from the study's findings.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a retrospective chart review of adults who underwent limb amputation at IRCCS Istituto Ortopedico Rizzoli between January 1, 2023 and December 31, 2025. Investigators will extract pain intensity, pain control measures, and functional recovery data from medical records and pain assessments. The study will describe the trajectory of early postoperative pain and recovery and perform exploratory analyses relating clinical, demographic, and therapeutic variables to primary outcomes. Patients with prior amputations, severe cognitive impairment, death or critical condition within 48 hours, or admissions for stump revision are excluded.

Why it matters

Potential benefit: If successful, the findings could help clinicians anticipate typical pain trajectories and tailor pain control and rehabilitation after amputation.

How similar studies have gone: Previous observational work has documented variable early post‑operative and phantom limb pain patterns, but comprehensive retrospective cohorts specifically focused on the immediate post‑operative trajectory remain limited.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients ≥ 18 years of age
* Patients who underwent an amputation to any limb, regardless of location or diagnosis

Exclusion Criteria:

* Patients with severe cognitive impairment or diagnosed with dementia
* Patients deceased or in critical conditions within 48 hours of the intervention
* Previous amputation to any limb
* Admission to the hospital because of a stump revision

Where it's running

  • IRCCS Istituto Ortopedico Rizzoli
    Bologna, Italy
    Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.