Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Effect of extraction site and local anesthesia on pain after laparoscopic appendectomy

Official title: Effect Of Specimen Extraction Site And Local Anesthesia On Postoperative Pain In Laparoscopic Appendectomy

Run by Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital · NCT07824908 · Data updated 2026-11-12

This study tests whether using the periumbilical versus left lower quadrant extraction site and routine port-site local anesthesia affect postoperative pain in adults with acute appendicitis undergoing laparoscopic appendectomy.

More Appendectomy, Laparoscopic trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment300 (estimated)
SponsorSaglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Academic / other
Locations1 site (Diyarbakır, Kayapınar)
StatusRecruiting
StartedApril 24, 2026
Main results expectedDecember 1, 2026
Study endsDecember 15, 2026
Registry record updatedSeptember 17, 2026
Trial IDNCT07824908 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults 18 years or older with acute appendicitis undergoing emergency laparoscopic appendectomy who consent to participate.

Probably not a fit

Patients whose pain is driven by factors other than extraction-site pain or who do not respond to local anesthesia infiltration may see no benefit.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective randomized trial compares two specimen extraction locations (periumbilical vs left lower quadrant) and the routine use of port-site local anesthesia infiltration in patients undergoing emergency laparoscopic appendectomy for acute appendicitis. Participants are randomly assigned to four groups based on extraction site and whether local anesthesia is used at trocar sites. The primary outcome is pain scores at extraction and non-extraction sites over the first 24 hours postoperatively, measured by the Numeric Rating Scale. Secondary outcomes include total analgesic use, operative time, and length of hospital stay.

Why it matters

Potential benefit: If successful, the approach could reduce postoperative pain and analgesic needs, improving recovery after laparoscopic appendectomy.

How similar studies have gone: Prior works in regional anesthesia and port-site analgesia have shown pain reduction in similar surgical settings, though this exact combination in laparoscopic appendectomy is novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Patients aged 18 years or older
* Diagnosed with acute appendicitis
* Scheduled for emergency laparoscopic appendectomy
* Informed consent obtained

Exclusion Criteria:

* Conversion to open surgery
* Known allergy to local anesthetics
* Cognitive impairment or inability to understand the NRS scoring system
* Pregnancy

Where it's running

  • Gazi Yasargil Training and Research Hospital
    Diyarbakır, Kayapınar, Turkey (Türkiye)
    Recruiting

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.