Continuous nefopam infusion after pancreatoduodenectomy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients undergoing elective pancreatoduodenectomy will receive one of three perioperative analgesic strategies—continuous nefopam infusion (120 mg/day), continuous lidocaine infusion, or epidural analgesia—as part of a multimodal pain management protocol. Researchers will track opioid consumption, patient-reported pain scores at predefined time points, and recovery quality using the QoR-15 questionnaire. Outcomes will be compared between groups to see which approach provides better pain control and reduces opioid requirements. The trial is conducted at a single tertiary gastrointestinal surgery center in Cluj-Napoca, Romania.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients scheduled for elective pancreatoduodenectomy surgery
2. Agreed to participate in the study

Exclusion Criteria:

1. Refusal to participate
2. Emergency surgery
3. Patients with neurological disorders or other muscular or psychiatric disorders that impede communication
4. Known allergic reactions to the used medication
5. Known hyperalgesia
6. Chronic opioid consumption
7. Patients that require reintervention in the first 48h postoperatively
8. Patients with pancreaticogastrostomy

Where it's running

• Prof. O. Fodor Regional Institute of Gastroenterology and Hepatology
  Cluj-Napoca, Cluj, Romania Recruiting

Study contacts

• Study coordinator: Andrei O Mitre
• Email: andrei.otto.mitre@elearn.umfcluj.ro
• Phone: +40724275556

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.