Prevalence of central sensitization signs in adults with ASD without intellectual disability
Presca : Prospective Study to Determine the Prevalence of Signs of Central Sensitization in Adults With ASD Without Intellectual Developmental Disorders
This project will see how common signs of central sensitization—which can change how pain is felt—are in adults with autism spectrum disorder who do not have intellectual disability.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Groupe Hospitalier Mutualiste de Grenoble Academic / other |
| Locations | 1 site (Grenoble, Isere) |
| Trial ID | NCT07495761 on ClinicalTrials.gov |
What this trial studies
This is a prospective observational study enrolling adults (age 18+) who have a medical diagnosis of autism spectrum disorder without an established intellectual developmental disorder. Participants must understand written French and will complete self-administered questionnaires and have relevant clinical information recorded to identify signs consistent with central sensitization and atypical pain processing. The study aims to estimate how frequently these signs occur in this specific adult ASD population and describe associated clinical features. The work is conducted at a single site (Groupe Hospitalier Mutualiste de Grenoble) and excludes individuals unable to complete self-report measures or to give informed consent.
Who should consider this trial
Good fit: Adults (18 years or older) with a clinician-diagnosed ASD who do not have an intellectual developmental disorder, who can understand written French, can provide consent, and are affiliated with a social security system are ideal candidates.
Not a fit: People with intellectual developmental disorders who cannot complete self-administered questionnaires, those who cannot read French, or those unable to give consent are unlikely to benefit from participation.
Why it matters
Potential benefit: If successful, the findings could improve recognition of pain-related central sensitization in adults with ASD and help clinicians tailor pain management and support.
How similar studies have performed: Prior research has documented altered sensory and pain processing in ASD, but systematic prospective estimates of central sensitization signs specifically in adults without intellectual disability remain limited, so this approach is relatively novel.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age ≥ 18 years 2. Medical diagnosis of ASD without established intellectual developmental disorder 3. Patient affiliated with a social security system or beneficiary of such a system 4. Understanding of written French (good comprehension of self-questionnaire questions) 5. No objection from the patient to participate in the study Exclusion Criteria: 1. Intellectual developmental disorder that prevents understanding of self-administered questionnaires 2. Individuals subject to legal or judicial protection measures or unable to express their consent
Where this trial is running
Grenoble, Isere
- Groupe Hospitalier Mutualiste de Grenoble — Grenoble, Isere, France (Recruiting)
Study contacts
- Study coordinator: Estelle ECR Cotte Raffour, Pain Resource Nurse
- Email: estelle.cotte-raffour@avec.fr
- Phone: +33 6 60 34 61 67
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.