Managing acute chest pain after combat-related thoracic injuries in Ukraine
Management of Acute Pain After Thoracic Combat Trauma: A Multicenter Study in Ukraine
NA · Lviv National Medical University · NCT07380789
This study will test whether cryoablation or radiofrequency ablation better controls severe chest pain and speeds recovery in adults with combat-related chest injuries treated at Ukrainian hospitals.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Lviv National Medical University (other) |
| Locations | 1 site (Rivne) |
| Trial ID | NCT07380789 on ClinicalTrials.gov |
What this trial studies
This prospective multicenter trial compares two minimally invasive nerve-targeting procedures—cryoablation and radiofrequency ablation—in adults with acute thoracic combat injuries at tertiary centers in Vinnytsia, Rivne, and Lviv. Both procedures target intercostal nerves to provide localized analgesia and are performed under imaging and clinical monitoring to minimize risks. Key outcomes include pain scores (VNRS), opioid consumption, pulmonary function tests, functional recovery, quality of life, and procedure-related safety during the acute recovery period. Eligible participants are adults with moderate-to-severe chest pain (VNRS ≥4) who can provide informed consent and do not meet exclusion criteria such as severe coagulopathy or infection at the intervention site.
Who should consider this trial
Good fit: Adults with recent combat-related thoracic injuries who have moderate-to-severe chest pain (VNRS ≥4), can give informed consent, and meet procedural safety criteria are ideal candidates.
Not a fit: Patients with severe coagulopathy, active infection at the intervention site, allergy to local anesthetics, inability to perform spirometry, or chest pain not originating from intercostal nerves may not receive benefit from these interventions.
Why it matters
Potential benefit: If successful, these procedures could provide faster, targeted pain relief with reduced opioid use and fewer pulmonary complications, improving recovery after thoracic combat injuries.
How similar studies have performed: Both cryoablation and radiofrequency ablation have shown pain relief and opioid-sparing effects in other thoracic and neuropathic pain settings, but direct comparative data in acute combat-related thoracic trauma are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥18 years * Thoracic trauma from combat-related injuries * VNRS ≥4 for acute thoracic pain * Ability to provide informed consent Exclusion Criteria: * Severe coagulopathy * Infection at intervention site * Allergy to local anesthetics * Inability to perform spirometry
Where this trial is running
Rivne
- Communal enterprise "Yuri Semenyuk Rivne Regional Clinical Hospital" of Rivne Regional Council — Rivne, Ukraine (RECRUITING)
Study contacts
- Study coordinator: Maksym Barsa, MD, PhD
- Email: maxbars@email.ua
- Phone: +380952074098
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Pain Management, Thoracic Trauma, Pulmonary Function, Quality of Life, Functional Outcome, Depression in Adults, Neuropathic Pain, Hypoesthesia