Combined distal femoral nerve block for pain relief after knee replacement
Official title: Comparative Study Assessing the Efficacy of a Combined Distal Femoral Nerve Block for Postoperative Analgesia Following Total Knee Arthroplasty (TKA)
Run by GCS Ramsay Santé pour l'Enseignement et la Recherche · NCT07629388 · Data updated 2026-11-12
This study tests whether using a combined distal femoral nerve block after knee replacement reduces opioid needs while keeping leg strength intact.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 240 (estimated) |
| Sponsor | GCS Ramsay Santé pour l'Enseignement et la Recherche Academic / other |
| Locations | 1 site (Dijon) |
| Status | Recruiting |
| Started | May 26, 2026 |
| Main results expected | May 25, 2027 |
| Study ends | May 25, 2027 |
| Registry record updated | October 5, 2026 |
| Trial ID | NCT07629388 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults undergoing planned total knee arthroplasty who can consent and are eligible for multimodal analgesia.
✕Probably not a fit
Patients with contraindications to local anesthetics or NSAIDs, those on preoperative opioids, or with conditions excluding participation may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares a combined distal femoral nerve block to a saphenous nerve block alone in adults undergoing total knee arthroplasty. All participants receive standard multimodal pain management. Outcomes include postoperative pain, opioid consumption in recovery, nausea, vomiting, quadriceps strength, time to first standing, and length of hospital stay. The aim is to see if the combined block provides better analgesia without compromising leg strength.
Why it matters
Potential benefit: If successful, patients may experience better pain control with less opioid use and preserved leg strength after knee surgery.
How similar studies have gone: Previous nerve block approaches have shown analgesic benefits in similar orthopedic procedures, but this specific combined distal femoral and saphenous block approach is being tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adult patients aged over 18 years. * Scheduled for total knee arthroplasty with multimodal analgesia. * Affiliated with or benefiting from a social security system. * Able to understand the study information and provide written informed consent. Exclusion Criteria: * Emergency surgery. * Weight under 50 kg. * Body mass index over 40 kg/m². * Contraindication to nefopam, non-steroidal anti-inflammatory drugs, local anesthetics, or morphine. * Preoperative opioid use. * Antidepressant or gabapentinoid treatment. * Other planned surgical or medical procedures during the study period. * Participation in another clinical trial, or currently in an exclusion period from another trial. * Inability to understand study information for linguistic, psychological, cognitive, or literacy reasons. * Pregnancy, possible pregnancy without effective contraception, or breastfeeding. * Protected adults, including those under guardianship, curatorship, legal protection, detention, or otherwise unable to give informed consent.
Where it's running
-
Hôpital privé Dijon Bourgogne
Dijon, France Recruiting
Study contacts
- Principal investigator: Antoine Sanchez, MD — Hôpital privé Dijon Bourgogne
- Study coordinator: Antoine Sanchez
- Email: sanchez.antoine@live.fr
- Phone: +33 3 80 40 01 14
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Dexmedetomidine as add-on for refractory cancer pain in palliative care
This study tests whether adding dexmedetomidine helps improve pain control for adults with cancer in palliative care whose pain remains high despite opioids.
-
Two Ways to Help Pain After Breast Surgery: Education-Based Analgesia vs Standard Care
This trial tests whether teaching patients about pain management and using a multimodal pain plan improves pain control and recovery after breast surgery compared with standard care.
-
Virtual Reality Therapy to Improve Arthroplasty Outcomes
This pilot test checks whether using virtual reality during the perioperative period helps knee or hip replacement patients feel better about their care and recover more easily.
-
Suzetrigine for pain relief after knee replacement
This trial tests whether suzetrigine can reduce opioid use after a total knee replacement compared with placebo.
-
Analgesic effects of adding BiFeS block to adductor canal block after ACL reconstruction
This study tests whether adding a BiFeS block to the standard adductor canal block provides better pain relief after ACL reconstruction.
-
Tegileridine for pain after bariatric surgery
This phase 3 trial tests tegileridine vs standard opioid medicine to see if it provides good pain relief after bariatric surgery while considering sleep apnea status.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.