Condition

Acute Pain clinical trials and research

• 34Clinical trials
• 10NIH research projects
• 14Countries

Newest Acute Pain clinical trials

All recruiting trials (34)

• Predictors of severe pain within 24 hours after cesarean delivery with spinal anesthesia

  This study will look at which pre-, intra-, and post-operative factors are linked to severe pain in the first 24 hours after an elective cesarean done with spinal anesthesia.

  Recruiting Bursa City Hospital · Bursa, Nilüfer · NCT07789301

• Transverse vs Longitudinal Serratus Anterior Plane Block for Breast Surgery

  This trial tests whether a longitudinal ultrasound view for serratus anterior plane block provides better pain relief after breast surgery than the standard transverse view.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle\Ankara · NCT07739277

• Combined PECS II and PIP blocks vs TPVB for post-mastectomy pain relief

  This trial tests whether a combination of PECS II and superficial PIP blocks can provide better or similar pain relief after mastectomy compared with the standard thoracic paravertebral block.

  Recruiting Dharmais National Cancer Center Hospital · Jakarta, DKI Jakarta · NCT07738770

• Ketamine or Dexmedetomidine as an Additive to Scalp Block for Brain Tumor Surgery

  This trial tests whether adding ketamine or dexmedetomidine to bupivacaine for scalp blocks improves pain control after supratentorial brain tumor removal.

  Recruiting at 2 sites Cairo University · Cairo, Governorate and 1 other locations · NCT07698665

• Rhythmic Skin Tapping and Internal Vibration for Pediatric Venipuncture Pain and Fear

  This study tests whether light fingertip tapping above the needle site or a humming sound can reduce pain and fear in children aged 6-12 during blood draws.

  Recruiting Akdeniz University · Antalya, Kepez · NCT07650591

• Brief audio-guided mindfulness for pain in orthopedic waiting rooms

  This trial tests whether listening to short mindfulness audio clips can help reduce pain for adults waiting for orthopedic care.

  Recruiting Florida State University · Tallahassee, Florida · NCT07562412

• LY4515100 for pain after impacted wisdom tooth removal

  This trial will test whether a single oral dose of LY4515100 reduces acute pain after impacted wisdom tooth removal compared with a placebo in adults having two or more third molars removed.

  Recruiting Phase 2 Eli Lilly and Company · Salt Lake City, Utah · NCT07511816

• Virtual reality relaxation to reduce pain during elective egg retrieval

  This tests whether about 20 minutes of relaxing VR nature scenes before elective egg retrieval can lower pain for women having egg freezing.

  Recruiting Hadassah Medical Organization · Jerusalem · NCT07484815

• Comparing a single erector spinae block to parasternal plus serratus blocks for pain after sternotomy

  We will see if a single erector spinae nerve block or a combination of superficial parasternal and serratus anterior blocks better controls pain and reduces opioid use in adults having elective open‑chest (sternotomy) heart surgery.

  Recruiting Uludag University · Bursa, Nilüfer · NCT07472296

• Intravenous oxytocin to change how skin nerves respond to heat and touch

  This study will test whether a single IV dose of oxytocin can reduce localized heat-induced pain and change how peripheral nerves respond in healthy adults aged 18–65.

  Recruiting Phase 2 Wake Forest University Health Sciences · Linköping · NCT07409753

• Using pupillometry to measure acute pain in children and teens

  This project will test whether a non-invasive pupillometry device (AlgometRx Nociometer) can provide an objective measure of acute pain in children and adolescents ages 6 to 21 who are having elective surgery or undergoing bone marrow transplantation.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT07336264

• Using a number-based pain score plus a simple activity score to guide rescue pain medicine after surgery

  This project will test whether using a combined numerical pain score and a simple Functional Activity Score to decide when to give rescue pain medicine helps adults recover after surgery.

  Recruiting Fundacin Biomedica Galicia Sur · Vigo · NCT07310953

• Retrolaminar block to reduce opioid use after lumbar fusion

  This study tests whether an ultrasound-guided retrolaminar block can cut opioid needs after lumbar fusion when paired with multimodal pain relief.

  Recruiting Pontificia Universidad Catolica de Chile · Santiago, Santiago Metropolitan · NCT07291388

• Two nerve-block options for pain control after inguinal hernia repair

  We'll test whether the anterior iliac block or the ilioinguinal/iliohypogastric block provides better pain relief and satisfaction after elective inguinal hernia surgery in adults aged 18–65.

  Recruiting Harran University · Şanliurfa, Hali̇li̇ye · NCT07290881

• Combogesic IV for acute pain in children

  A pediatric study is testing a vein-administered combination pain medicine (ibuprofen and acetaminophen) to see how it works and how safe it is for children and teens aged 2 to under 17 who have acute pain and need IV pain relief.

  Recruiting at 4 sites Phase 3 AFT Pharmaceuticals, Ltd. · Budapest and 3 other locations · NCT07225634

• Rectus Sheath Block technique comparison in adults

  This study tests two ultrasound-guided ways of delivering a rectus sheath block to see which method better spreads anesthetic and covers more nerves in adults having abdominal procedures.

  Recruiting Phase 2 Duke University · Durham, North Carolina · NCT07068243

• Cooling the skin to reduce pain from arterial puncture

  This study is testing if cooling the skin can help reduce pain during arterial punctures for people who need this medical procedure.

  Recruiting The Second Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06838572

• Using liposomal bupivacaine for pain relief after lung surgery

  This study is testing whether a new form of pain relief called liposomal bupivacaine can help people manage pain better after lung surgery compared to the standard treatment.

  Recruiting Phase 4 The Second Affiliated Hospital of Chongqing Medical University · Chongqing, Chongqing Municipality · NCT06569953

• Whether intense pain before emergency surgery leads to long-term pain after the operation

  We will test whether people having emergency abdominal or orthopedic surgery who have strong pain before the operation are more likely to have ongoing pain three months afterward.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT06555107

• Mindfulness intervention for pain management before orthopedic procedures

  This study tests if a short mindfulness exercise can help people feel less pain before they have orthopedic procedures like kyphoplasty or radiofrequency ablation.

  Recruiting Florida State University · Tallahassee, Florida · NCT06471075

• Understanding how psychological factors affect pain management in surgery

  This study looks at how feelings and worries about pain affect how well regional anesthesia works for people having surgery.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT06466941

• Using virtual reality to help manage pain in sickle cell disease patients

  This study is testing if using virtual reality can help adults with sickle cell disease feel less pain during painful episodes.

  Recruiting University of Maryland, Baltimore · Baltimore, Maryland · NCT06184126

• Comparing Ketorolac and Morphine for Pain Relief in Children with Appendicitis

  This study is testing if ketorolac can help relieve pain just as well as morphine in children aged 6-17 who might have appendicitis.

  Recruiting Phase 3 University of Calgary · Calgary, Alberta · NCT06160778

• Using open-label placebos to reduce acute pain in healthy adults

  This study tests whether open-label placebos can help healthy adults feel less pain from simulated wounds caused by electrical stimulation.

  Recruiting University Hospital, Basel, Switzerland · Basel · NCT05819476

• Using a smartphone app to track pain and mood changes

  This study is testing a smartphone app to track pain and mood changes in people with chronic pain and healthy individuals to see how these factors affect pain over time.

  Recruiting Brown University · Providence, Rhode Island · NCT05754190

• Comparing two methods of pain relief after cesarean delivery

  This study is testing which pain relief method, Surgical Transversus Abdominis Plane Block or Ultrasound Guided TAPB, works better for women having a cesarean delivery.

  Recruiting Al-Azhar University · Cairo · NCT05750992

• Improving pain assessment in preterm infants using machine learning

  This study is testing a new way to use machine learning to better understand and measure pain in preterm infants in the NICU during routine procedures.

  Recruiting at 2 sites York University · Toronto, Ontario and 1 other locations · NCT05579496

• Reducing pain from wisdom tooth extractions

  This study is testing a new pain relief method for people getting their lower wisdom teeth removed to see if it can help reduce the need for opioid painkillers.

  Recruiting Phase 2 Rutgers, The State University of New Jersey · Newark, New Jersey · NCT05335070

• Evaluating the effects of exercise therapy on veterans' health

  This study tests whether a specific exercise program can help U.S. veterans with chronic pain, fatigue, and depression feel better physically and mentally.

  Recruiting University of Illinois Chicago · Chicago, Illinois · NCT05094297

• Using Twin Block anesthesia to manage pain after wisdom tooth removal

  This study is testing if a new dental anesthesia technique called Twin Block can help reduce pain after wisdom tooth removal compared to a placebo.

  Recruiting Phase 2 Rutgers, The State University of New Jersey · Newark, New Jersey · NCT04880707

• Using erector spinae plane block catheters with intrathecal morphine for pain relief after liver surgery

  This study is testing if using special catheters for pain relief along with morphine can help people recovering from liver surgery feel less pain and recover faster compared to standard pain management.

  Recruiting Phase 4 University of California, San Diego · San Diego, California · NCT04849455

• Using magnesium infusion to manage pain in critically ill trauma patients

  This study is testing if giving magnesium through an IV can help manage pain and reduce the need for opioids in critically ill trauma patients in the ICU.

  Recruiting Phase 4 University of California, Davis · Sacramento, California · NCT04166877

• Investigating the effects of a specific pain relief technique on breathing after abdominal surgery

  This study is testing if a special pain relief technique can help people breathe better and feel less pain after having abdominal surgery.

  Recruiting Assiut University · Asyut, Assiut Governorate · NCT03725527

• Vasopressin and Observational Analgesia in Healthy Volunteers

  We are testing whether intranasal vasopressin changes how people’s pain is shaped by watching others experience pain while in an MRI scan.

  Recruiting Phase 1/2 University of Maryland, Baltimore · Baltimore, Maryland · NCT03446456

NIH-funded research (10)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Multi-Site Feasibility Study to Prepare for a Clinical Trial on Battlefield Acupuncture, Battlefield Acupressure, or Sham for Acute Pain

  A team at UC San Diego is testing a non-drug, needle-free and needle-involved acupuncture approach to treat acute postoperative pain and reduce reliance on opioids.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11442963

• Non-viral gene therapy to relieve acute focal pain

  A new non-opioid gene therapy delivered by lipid nanoparticles aims to reduce pain from acute surgical and other focal pain conditions, potentially lowering the need for opioid medications.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11418135

• IV ketamine vs morphine for acute pain in children

  A new comparison in kids with acute pain will test whether a low-dose IV ketamine works as well as IV morphine for pain relief and safety in the emergency department.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11401174

• IV low-dose ketamine versus IV morphine for treating children's sudden pain

  This project compares low-dose IV ketamine and IV morphine to relieve sudden moderate-to-severe pain in children and teens who come to the emergency department.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11184435

• Comparing ketamine and morphine for treating acute pain in children.

  This study is looking at whether a lower dose of ketamine can help kids in the emergency room feel better from pain compared to morphine, with the goal of finding a safer and more effective way to treat their pain.

  NIH research Columbia University Health Sciences · New York, United States · NIH-10990856

• Investigating how the body processes endocannabinoids to manage acute pain

  This study is looking at how a natural substance in the body called 2-AG helps manage pain, especially for people recovering from major surgeries, with the goal of finding safer pain relief options that don’t involve addictive opioids.

  NIH research State University New York Stony Brook · Stony Brook, United States · NIH-10783795

• Improving pain treatment for infants and young children

  This study is all about finding better ways to understand and measure pain in babies and young kids so that doctors can create safer and more effective pain relief options for them.

  NIH research Duke University · Durham, United States · NIH-10783106

• Creating a device to use focused ultrasound for pain relief without injections

  This study is testing a new, noninvasive device that uses focused ultrasound to help block pain signals for people dealing with moderate to severe acute pain, offering a safer alternative to traditional pain relief methods like opioids and injections.

  NIH research Stanford University · Stanford, United States · NIH-10740796

• Targeting sensory neurons to manage acute pain

  This study is exploring a new way to help people with sudden pain feel better using a special protein that targets the nerves responsible for pain, aiming to provide relief without the risks of addiction or side effects from regular pain medications.

  NIH research Neurocarrus, INC. · Monterey, United States · NIH-10603436

• Using mobile health data to predict pain in children with sickle cell disease

  This study is looking to help kids with sickle cell disease by using mobile health data to predict when they might have painful episodes, so they can get the right care at the right time and feel better overall.

  NIH research Virginia Commonwealth University · Richmond, United States · NIH-10599401

Related topics

Quick answers

How many Acute Pain clinical trials are recruiting right now?

34, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (14 trials), Turkey (Türkiye) (5 trials), Egypt (3 trials), Canada (2 trials), China (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 4: 3, Phase 3: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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