Understanding pain management after orthopedic surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to define the Minimum Clinically Important Difference (MCID) and Patient Acceptable Symptom State (PASS) for patients undergoing various elective major orthopedic surgeries. It focuses on assessing acute postoperative pain, which affects a significant portion of surgical patients, and seeks to establish valid MCID values specific to acute pain rather than relying on chronic pain data. The study will utilize both anchor-based and distribution-based methods to evaluate patient-reported outcomes related to pain relief. By improving pain assessment, the study aims to enhance analgesic therapy and overall recovery for patients.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients aged 18-80 years
* ASA class I - III
* Primary elective surgery
* unilateral major shoulder surgery e.g., stabilization and arthroplasty procedures:
* unilateral total hip replacement
* unilateral total knee replacement, and
* spinal decompression + fusion involving ≥ 2 levels.
* Hospital admission for ≥ 24 hours after the surgery

Exclusion Criteria:

* Inability to give informed consent
* Poor English comprehension
* Psychiatric disorders e.g., dementia
* Known allergies to morphine / hydromorphone
* Chronic substance abuse and use of recreational drugs
* Any medical disorder that impairs accurate and objective completion of questionnaires

Where it's running

• Toronto Western Hopspital
  Toronto, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Anahi Perlas, MD, FRCPC — University Health Network, Toronto
• Study coordinator: Jayanta Chowdhury, MBBS,MD
• Email: jayanta.chowdhury@uhn.ca
• Phone: 4166035800

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.