Liposomal bupivacaine for rhomboid intercostal nerve block to reduce pain after VATS

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional study enrolls adults aged 18–64 undergoing elective video‑assisted thoracoscopic lobectomy or wedge resection under general anesthesia who meet ASA I–III criteria. During the perioperative period participants will receive a rhomboid intercostal block using either standard bupivacaine or liposomal bupivacaine plus bupivacaine, with postoperative pain scores, opioid consumption, and safety outcomes recorded. The protocol excludes patients with chronic pain syndromes, certain cardiac conditions, active bleeding or coagulation disorders, insulin‑treated diabetes, or ongoing anticoagulant use. Outcomes will focus on duration and intensity of postoperative analgesia and any adverse events related to the block or medications.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients scheduled for elective video-assisted thoracoscopic lobectomy or wedge resection under general anesthesia;
* Ages 18 to 64 years old；
* American Society of Anesthesiologists (ASA) physical status of I-III；
* Glasgow Coma Scale (GCS) score of 15；
* Patients must be able to understand the nature and potential personal consequences of the clinical trial, signing of the informed consent form.

Exclusion Criteria:

* History of chronic pain syndrome of any cause.
* Patients with heart conduction block (sinus block or atrioventricular block).
* Patients with unstable coronary artery disease.
* Patients with gastric ulcer or gastric bleeding.
* Patients with diabetes and are being treated with insulin.
* Subjects with coagulation dysfunction (prothrombin time or activated partial thromboplastin time is higher than the normal threshold) or patients who are taking oral anticoagulants for other medical reasons and have not stopped it before surgery, such as warfarin or new anticoagulants rivaroxaban or dabigatran.
* Patients with abnormal liver function: alanine aminotransferase (ALT) and/or aspartate aminotransferase (AST) \> 2× the upper limit of normal (ULN) or total bilirubin (TBIL) ≥ 1.5×ULN.
* Patients with renal impairment (serum creatinine \> 176 µmol/L) or receiving dialysis treatment within 28 days before surgery.
* Patients with a history of diagnosed mental illness or currently taking psychotropic medication.
* Excessive alcohol or drug abuse, chronic opioid use (more than 2 weeks or 3 days per week for more than 1 month), use of drugs with confirmed or suspected sedative or analgesic effects, or use of any painkiller within 24 h before surgery.
* Pregnancy or breastfeeding.
* Extreme body mass index (BMI) (\< 15 or \> 35).
* Participation in another interventional trial that interferes with the intervention or outcome of this trial.
* Patients with a history of allergy to local anaesthetics or one of the study drugs.

Where it's running

• Beijing Tiantan Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Fang Luo — Beijing Tiantan Hospital
• Study coordinator: Fang Luo
• Email: 13611326978@163.com
• Phone: +86 13611326978

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Liposomal bupivacaine to reduce pain after VATS

  This test will see if a long‑acting liposomal bupivacaine injection at the incision eases postoperative pain for adults having VATS lung surgery.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT07432711

• Dexmedetomidine as add-on for refractory cancer pain in palliative care

  This study tests whether adding dexmedetomidine helps improve pain control for adults with cancer in palliative care whose pain remains high despite opioids.

  Recruiting St. Olavs Hospital · Drammen and 3 other locations · NCT07885475

• Two Ways to Help Pain After Breast Surgery: Education-Based Analgesia vs Standard Care

  This trial tests whether teaching patients about pain management and using a multimodal pain plan improves pain control and recovery after breast surgery compared with standard care.

  Recruiting University General Hospital of Heraklion · Heraklion, Crete · NCT07880223

• Virtual Reality Therapy to Improve Arthroplasty Outcomes

  This pilot test checks whether using virtual reality during the perioperative period helps knee or hip replacement patients feel better about their care and recover more easily.

  Recruiting NHS Highland Research, Development and Innovation Organisation · Inverness, Highlands · NCT07872670

• Suzetrigine for pain relief after knee replacement

  This trial tests whether suzetrigine can reduce opioid use after a total knee replacement compared with placebo.

  Recruiting Phase 3 Hospital for Special Surgery, New York · New York, New York · NCT07864896

• Analgesic effects of adding BiFeS block to adductor canal block after ACL reconstruction

  This study tests whether adding a BiFeS block to the standard adductor canal block provides better pain relief after ACL reconstruction.

  Recruiting Ankara Etlik City Hospital · Ankara · NCT07859397

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.