Comparing pain relief methods during medical abortion
Effectiveness of Proactive Versus On-Demand Pain Relief With Non-Steroidal Anti-Inflammatory Drugs During Medical Abortion at 13 to 22 Weeks at Hung Vuong Hospital
This study is testing whether taking pain relief medication before a medical abortion helps women feel less pain compared to taking it only when they need it.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 180 (estimated) |
| Ages | 18 Years and up |
| Sex | Female |
| Sponsor | Hung Vuong Hospital Academic / other |
| Locations | 1 site (Ho Chi Minh City) |
| Trial ID | NCT06696573 on ClinicalTrials.gov |
What this trial studies
This clinical trial evaluates the effectiveness of non-steroidal anti-inflammatory drugs (NSAIDs) for pain management during medical abortion procedures for pregnancies between 13 and 22 weeks. Participants will be divided into two groups: one receiving NSAIDs prophylactically and the other receiving them on-demand as pain occurs. The study aims to determine if the prophylactic approach leads to better pain relief outcomes and to assess any potential adverse effects associated with NSAID use in this context. Pain levels will be monitored using validated scales throughout the procedure.
Who should consider this trial
Good fit: Ideal candidates are pregnant women aged 18 and older, between 13 and 22 weeks of gestation, who are seeking a medical abortion.
Not a fit: Patients with contraindications to medical abortion or those with certain medical conditions may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a more effective pain management strategy for women undergoing medical abortion.
How similar studies have performed: Previous studies have shown varying success with NSAIDs in pain management, but this specific approach in the context of medical abortion is less explored.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Pregnant women aged 18 years or older. * No mental illness. * Gestational age between 13 and 22 weeks (based on the last menstrual period with a regular menstrual cycle and accurate recall of the last menstrual period, or based on a first-trimester ultrasound) with an indication of stillbirth, fetal malformation requiring termination, or voluntary abortion with counseling and understanding of the abortion procedure. * Willing to participate in the study. * Capable of reading and signing the informed consent form. * Able to provide personal information independently. Exclusion Criteria: * Medical conditions contraindicating medical abortion: bleeding disorders, anticoagulant use, moderate to severe anemia. * Cardiovascular conditions: heart failure, mitral valve stenosis, embolism, uncontrolled hypertension. * Other medical conditions: renal failure, adrenal gland disorders, severe asthma, liver and biliary diseases, glaucoma. * Active pelvic inflammatory disease or acute genital infections. * Previous uterine surgery. * Placenta previa or central placenta previa. * Uterine malformations. * History of allergy to NSAIDs, Mifepristone, or Misoprostol. * Unwillingness to participate in the study.
Where this trial is running
Ho Chi Minh City
- Hung Vuong Hospital — Ho Chi Minh City, Vietnam (Recruiting)
Study contacts
- Study coordinator: Le Trang, MD
- Email: lethikieutrang912@gmail.com
- Phone: +8434615919
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.