Tegileridine for pain after bariatric surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized, double-blind study will assign adults undergoing elective bariatric surgery to receive tegileridine or sufentanil for postoperative pain management. Participants are stratified by obstructive sleep apnea status and unaware of which treatment they receive. The primary outcome is recovery quality in the first 24 hours after surgery, measured by QoR-15, with secondary data on pain scores, rescue analgesia use, and adverse effects over seven days. The trial is single-center and aims to determine the safety and analgesic efficacy of the new biased μ-opioid receptor agonist in this population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 to 65 years old
* Scheduled for elective bariatric surgery
* American Society of Anesthesiologists (ASA) physical status I, II or III
* Able to understand and complete the QoR-15 questionnaire
* Provide written informed consent to participate in the study

Exclusion Criteria:

* Known allergy or hypersensitivity to opioids, tegileridine or sufentanil
* Severe hepatic or renal dysfunction
* Preoperative chronic opioid use
* History of severe respiratory disease except obstructive sleep apnea
* Pregnant or breastfeeding women
* Participants who cannot complete postoperative follow-up
* Participation in another interventional clinical trial within 30 days before surgery

Where it's running

• The First Hospital of Jilin University
  Changchun, Jilin, China Recruiting

Study contacts

• Study coordinator: Meikun Wang, MD
• Email: wangmkjdyy@jlu.edu.cn
• Phone: +8613578774973

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.