QLESP Block vs PENG+LFCN Block for Total Hip Arthroplasty

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In adults undergoing unilateral total hip arthroplasty, the study compares two ultrasound-guided nerve block methods for postoperative pain control. Participants are randomized to receive either the novel QLESP block or the conventional PENG+LFCN block, with all patients also getting standard general anesthesia and multimodal analgesia. The primary goal is to see which block yields lower pain scores and less opioid use in the first 24 hours after surgery, while also monitoring early functional recovery. An exploratory biomarker sub-study will analyze plasma proteomic profiles to explore potential mechanisms behind differing pain responses. The trial is single-center, assessor-blinded, and plans to enroll 140 participants with 48-hour follow-up.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 to 70 years
* Scheduled for elective unilateral total hip arthroplasty via posterolateral approach
* American Society of Anesthesiologists (ASA) physical status I-III
* Body mass index (BMI) \< 35 kg/m²
* Ability to understand pain scoring and patient-controlled analgesia (PCA) use
* Willing and able to provide written informed consent

Exclusion Criteria:

* Allergy or hypersensitivity to local anesthetics (ropivacaine)
* Long-term opioid use or chronic pain history requiring regular analgesic use
* Active malignancy or infection at the puncture site
* Severe psychiatric disorders or communication barriers
* Severe cardiopulmonary disease
* History of opioid abuse or substance dependence
* Participation in another interventional clinical trial within 3 months prior to enrollment
* Coagulation abnormalities
* Pregnancy or breastfeeding
* Any condition that, in the investigator's opinion, would compromise patient safety or data integrity

Where it's running

• Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
  Wuhan, Hubei, China Recruiting

Study contacts

• Study coordinator: Xi Wu
• Email: wu2018whuh@163.com
• Phone: +8615871715431

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.