R.E.C.K versus Exparel for pain control during robotic kidney removal

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center, prospective, randomized phase 3 trial compares intraoperative R.E.C.K (ropivacaine with epinephrine, clonidine, and ketorolac) to Exparel (liposomal bupivacaine) in adults undergoing robotic partial or radical nephrectomy. Investigators will record intraoperative opioid use from the medical record and capture post-anesthesia care unit and inpatient pain scores using the Numerical Rating Scale along with oral and IV opioid and over-the-counter analgesic intake and length of stay. After discharge, participants will log time-stamped pain scores and self-administered analgesics in a provided take-home diary. The goal is to determine whether any improvements with Exparel justify its higher cost compared with the R.E.C.K cocktail.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Ability to understand and willingness to sign an IRB-approved informed consent
2. Age ≥ 18 years at the time of consent.
3. Planned robotic partial or radical nephrectomy

Exclusion Criteria:

1. Determined not to be a candidate to receive R.E.C.K or Exparel per the enrolling investigator
2. Known pregnancy
3. Chronic opioid use within 30 days (as per patient report) prior to randomization (defined as ≥ 30 MME/day)
4. Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements as determined by the investigator.
5. Known allergy to R.E.C.K. and/or Exparel

Where it's running

• Levine Cancer
  Charlotte, North Carolina, United States Recruiting

Study contacts

• Principal investigator: Roy Ornob, MD — Wake Forest University Health Sciences

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.