Condition

Bipolar Disorder clinical trials and research

• 71Clinical trials
• 43NIH research projects
• 24Countries

Newest Bipolar Disorder clinical trials

All recruiting trials (71)

• Effects of comorbidity on people with severe mental illness

  This study tests how having both alcohol/substance use and a severe mental illness affects hospitalizations, medications, and social participation among adults followed at a mental health center.

  Recruiting Abant Izzet Baysal University · Bolu, Bolu · NCT07692984

• Venous Tourniquet with Low-Dose Sugammadex vs Arterial Tourniquet for Seizure Monitoring During ECT

  40 patients undergoing ECT will have a venous tourniquet on one arm and an arterial tourniquet on the other to see which method better reveals motor seizures.

  Recruiting Medipol University · Istanbul · NCT07534475

• 7T MRI and visual perception markers for severe mood and psychotic disorders

  This project tests whether 7‑tesla MRI scans combined with visual perception tests can identify brain markers linked to diagnosis and treatment outcomes in adults with major depressive disorder, bipolar disorder, or schizophrenia.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT07479758

• Emotional Eating, Sleep Quality, Mental State, and Metabolic Syndrome in Psychiatric Patients

  This study tests how mood, sleep, and emotional eating relate to metabolic syndrome in people with schizophrenia or bipolar disorder.

  Recruiting Abant Izzet Baysal University · Bolu, Bolu · NCT07411222

• À deux, c'est mieux — group program to improve romantic relationships for young adults with severe mental illness

  This program will try a 12-week, small-group course to help single adults with severe mental illness build skills for dating, communication, and closer social relationships.

  Recruiting at 2 sites Centre hospitalier de Ville-Evrard, France · Épinay-sur-Seine, Île-de-France Region and 1 other locations · NCT07316803

• Brenipatide for adults with bipolar disorder (RENEW-Bipolar-1)

  This trial will test whether adding brenipatide to standard bipolar medications can delay worsening of symptoms in adults with bipolar I or II.

  Recruiting at 84 sites Phase 2 Eli Lilly and Company · Orange, California and 86 other locations · NCT07286175

• Olanzapine for people with bipolar disorder

  This project tests how people with bipolar disorder use olanzapine and whether teaching them about weight gain helps prevent it.

  Recruiting Boryung Pharmaceutical Co., Ltd · Seongnam · NCT07263191

• KarXT added to lithium, valproate, or lamotrigine for treating mania in Bipolar I

  This will test whether adding KarXT to a stable mood stabilizer (lithium, valproate, or lamotrigine) helps adults hospitalized for an acute manic episode of bipolar I disorder reduce their manic symptoms.

  Recruiting at 75 sites Phase 3 Bristol-Myers Squibb · Bentonville, Arkansas and 108 other locations · NCT07140913

• Valbenazine for adults with tardive dyskinesia who remain symptomatic on or after a VMAT2 inhibitor

  This trial will test whether valbenazine reduces involuntary movements in adults with tardive dyskinesia who still have symptoms while taking or after stopping a VMAT2 inhibitor.

  Recruiting at 19 sites Phase 4 Neurocrine Biosciences · Bryant, Arkansas and 18 other locations · NCT07105111

• ABBV-932 with itraconazole in bipolar disorder: how the drug moves through the body and what side effects occur

  This early-phase study tests whether ABBV-932, taken with itraconazole, is safe and how it behaves in adults with bipolar disorder.

  Recruiting Phase 1 AbbVie · Los Alamitos, California and 1 other locations · NCT07071532

• Neuro-computational look at mood fluctuations in depression and bipolar disorder.

  This tests whether combining brain scans, cognitive tests, and daily smartphone mood tracking can model and help predict mood changes in people with depression or bipolar disorder.

  Recruiting at 2 sites Centre Hospitalier St Anne · Paris, Paris and 1 other locations · NCT07033923

• Predicting bipolar disorder risk in children and teens with family history or atypical depression

  This project will try a prediction model to see if it can identify children and adolescents at high risk for bipolar disorder, including offspring of people with bipolar disorder and youths with atypical depression.

  Recruiting Shanghai Mental Health Center · Shanghai, Shanghai Municipality · NCT07031661

• Non-invasive ear (auricular) vagus nerve stimulation for depression

  This study will test whether non-invasive ear (auricular) vagus nerve stimulation helps adults with major depressive or bipolar depressive episodes and which biological markers change with treatment.

  Recruiting Max-Planck-Institute of Psychiatry · Munich · NCT07022171

• Mindfulness training for caregivers of people with bipolar disorder

  This study tests whether mindfulness training can help caregivers of people with bipolar disorder feel less stressed and improve their overall well-being.

  Recruiting Pamukkale University · Afyonkarahisar · NCT06983834

• Identifying markers of apathy in elderly patients with bipolar disorder

  This study is trying to find signs of apathy in older adults with bipolar disorder to see if they are at risk for memory problems and dementia.

  Recruiting Hospital Center Guillaume Régnier · Rennes, Ile Et Vilaine · NCT06914284

• Visual perception in schizophrenia and related disorders

  We will test whether EEG recordings of visual processing can find brain markers of psychosis in adults with schizophrenia, schizoaffective disorder, or bipolar disorder.

  Recruiting University of Rochester · Rochester, New York · NCT06911931

• Enhancing Veteran-Clinician Collaboration in VA Care for Serious Mental Illness

  This study tests a 10-session group program to help Veterans with serious mental illness collaborate better with their clinicians and care teams.

  Recruiting VA Office of Research and Development · San Diego, California and 2 other locations · NCT06898879

• Measuring brain activity in mood disorders and mild cognitive impairment

  This study is testing brain activity in people with mood disorders and mild cognitive impairment to see how it relates to their symptoms using a safe and noninvasive method.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT06897670

• Cognitive Behavioral Therapy for Chronic Pain in Veterans with Serious Mental Illness

  This study will test whether Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) helps Veterans with serious mental illness and chronic low back pain reduce pain-related interference and improve quality of life.

  Recruiting VA Office of Research and Development · Baltimore, Maryland · NCT06758414

• Investigating the link between Frontotemporal Dementia and Bipolar Disorder using neuroimaging and epigenetics

  This study is trying to see how changes in the brain and genes might connect Frontotemporal Dementia and Bipolar Disorder by looking at patients with these conditions and healthy people.

  Recruiting Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Milan, MI · NCT06706687

• Peer-delivered illness self-management program for college students with serious mental illnesses

  This study tests if a peer-led program called Taking Action can help college students with serious mental illnesses manage their condition better and improve their academic performance.

  Recruiting Temple University · Philadelphia, Pennsylvania · NCT06700902

• Metabolic care for patients with severe mental illness

  This study is testing a special clinic for people with severe mental illness to see if it helps them manage weight and heart health better than regular care.

  Recruiting University of Copenhagen · Glostrup Municipality, Capital Region · NCT06624462

• Improving rehabilitation for veterans with serious mental illness

  This study is testing a new computer program to help veterans with serious mental illnesses improve their thinking and daily life skills.

  Recruiting VA Office of Research and Development · San Diego, California · NCT06586164

• Physical exercise to improve cognitive function in bipolar disorder patients

  This study is testing if a structured exercise program can help improve thinking skills and quality of life for people with bipolar disorder.

  Recruiting University of Sao Paulo · São Paulo, São Paulo · NCT06560749

• Exploring Healthy Lifestyles for Bipolar Disorder in the Bay Area

  This study is testing if following a time-restricted eating plan for eight weeks can help people with bipolar disorder feel better and improve their sleep and mood.

  Recruiting University of California, Berkeley · Berkeley, California · NCT06555406

• Evaluating the EDIT-B Blood Test for Patients with Major Depression

  This study is testing a new blood test to see if it can help doctors better understand and treat people aged 18 to 65 who are dealing with major depression.

  Recruiting at 3 sites Alcediag · Erstein and 6 other locations · NCT06507787

• Program to help individuals with psychotic and bipolar disorders manage stigma and disclosure

  This study is testing a new program to help adults with psychotic and bipolar disorders learn how to handle stigma and decide when to share their mental health challenges with others.

  Recruiting Oslo University Hospital · Oslo and 1 other locations · NCT06384755

• Exploring how diet affects brain function in bipolar disorder

  This study is testing how different diets, specifically glucose and ketones, affect brain function and behavior in people with bipolar disorder compared to healthy individuals.

  Recruiting at 2 sites Stony Brook University · Belmont, Massachusetts and 2 other locations · NCT06373016

• Effects of theta burst stimulation on sleep and fatigue in depression

  This study is testing if two types of brain stimulation can improve sleep and reduce tiredness in people with depression.

  Recruiting Jagiellonian University · Warsaw · NCT06371352

• Using theta-burst stimulation to treat bipolar depression

  This study is testing if a new brain stimulation technique can help people with bipolar disorder who haven't found relief from their depression.

  Recruiting at 2 sites Centre for Addiction and Mental Health · Toronto, Ontario and 1 other locations · NCT06370988

• Using rTMS to treat mood and cognitive symptoms of depression

  This study is testing if a new way of using brain stimulation can help improve mood and thinking problems in people with unipolar and bipolar depression who haven't found relief from regular treatments.

  Recruiting Jagiellonian University · Krakow · NCT06363981

• Comparing two types of exercise therapy for mental disorders

  This study is testing whether a standard high-intensity workout or a shorter, easier version is better for improving mental health in people with schizophrenia or bipolar disorder.

  Recruiting Haukeland University Hospital · Bergen · NCT06313918

• Using brain stimulation to improve emotion regulation in bipolar disorder

  This study is testing if a special type of brain stimulation can help people with bipolar disorder better manage their emotions during depressive episodes.

  Recruiting at 2 sites Massachusetts General Hospital · Charlestown, Massachusetts and 1 other locations · NCT06274567

• Assessing the safety of lumateperone in young patients with schizophrenia or bipolar disorder

  This study is testing if lumateperone is safe for young people with schizophrenia or bipolar disorder who will take the medication daily for 26 weeks.

  Recruiting at 52 sites Phase 3 Intra-Cellular Therapies, Inc. · Phoenix, Arizona and 64 other locations · NCT06229210

• Using melatonin to improve mood and sleep in bipolar disorder

  This study is testing if a low dose of melatonin, along with a sleep program, can help improve mood and sleep for people with bipolar disorder.

  Recruiting Phase 2 University of Michigan · Ann Arbor, Michigan · NCT06226025

• Using mobile health technology to predict bipolar disorder episodes in veterans

  This study is testing a smartphone app that helps veterans with bipolar disorder spot early signs of mood episodes so they can get help before things get worse.

  Recruiting VA Office of Research and Development · Minneapolis, Minnesota · NCT06204705

• Nutritional counseling for patients with schizophrenia or bipolar disorder

  This study is testing whether nutritional counseling can help people with schizophrenia or bipolar disorder feel better over six weeks compared to those who don’t receive the counseling right away.

  Recruiting at 2 sites Vestre Viken Hospital Trust · Drammen, Akershus and 1 other locations · NCT06197048

• Exploring how the ketogenic diet affects brain function in bipolar disorder

  This study is testing whether following a ketogenic diet can improve brain function and reduce mood swings in adults with bipolar disorder.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06081426

• Enhanced care for early psychosis treatment

  This study is testing whether a new, more supportive treatment for people experiencing their first episode of psychosis helps them stay engaged in their care better than standard treatment.

  Recruiting at 5 sites Mclean Hospital · Belmont, Massachusetts and 4 other locations · NCT06071858

• Premorbid Personality Profile in bvFTD, phFTD, frontal AD, and bipolar disorder

  This study tests whether premorbid personality traits help explain social and behavioral changes in people with bvFTD, phFTD, frontal variant Alzheimer’s, or bipolar disorder.

  Recruiting Nantes University Hospital · Nantes · NCT06059313

• Using Cannabidiol to Treat Bipolar Depression

  This study is testing if adding cannabidiol (CBD) to the treatment plan can help people with bipolar depression who haven't felt better with standard medications.

  Recruiting at 3 sites Phase 3 University of British Columbia · Vancouver, British Columbia and 5 other locations · NCT05867849

• App plus smart body fat scale program to help overweight people with schizophrenia or bipolar disorder lose weight

  See if using the Huawei Health app together with a smart body fat scale helps overweight people with schizophrenia or bipolar disorder lose weight and stay involved in their care.

  Recruiting Capital Medical University · Beijing, Beijing Municipality · NCT05866107

• Understanding how alcohol affects young adults with bipolar disorder

  This study looks at how alcohol affects young adults with bipolar disorder compared to their peers to see if it leads to problems with drinking over time.

  Recruiting University of Texas at Austin · Austin, Texas · NCT05838274

• Predicting mood episode recurrence in bipolar and depressive disorders

  A wearable-based study to see if heart rate, sleep, activity, and mood data from a smartwatch can help predict when manic or depressive episodes will come back in people with bipolar or depressive disorders.

  Recruiting National Taiwan University Hospital · Taipei · NCT05828056

• Real-time fMRI Neurofeedback to Reduce Residual Symptoms in Bipolar Disorder

  This trial will try using real-time fMRI neurofeedback to help adults with bipolar disorder reduce persistent depressive and emotional symptoms between mood episodes.

  Recruiting Assistance Publique - Hôpitaux de Paris · Créteil, val-de-marne · NCT05802446

• Examining how AMPA receptor blockade affects Ketamine's ability to reduce suicidal thoughts

  This study is testing if a medication called perampanel can improve the effects of Ketamine in reducing suicidal thoughts and depression in people with major depressive disorder, bipolar disorder, or PTSD.

  Recruiting Phase 2 Yale University · West Haven, Connecticut · NCT05786066

• Personalized mobile app for cognitive behavioral therapy

  This study is testing if a personalized mobile app for cognitive behavioral therapy can help young people with anxiety, depression, or bipolar disorder just as much as a standard app.

  Recruiting Weill Medical College of Cornell University · New York, New York · NCT05699525

• Compassion-focused therapy for reducing self-stigma in mental health disorders

  This study is testing whether Compassion Focused Therapy can help people with mental health disorders feel better about themselves and reduce feelings of shame.

  Recruiting University Hospital, Strasbourg, France · Bordeaux and 6 other locations · NCT05698589

• Understanding the link between exercise and mood in bipolar disorder

  This study is trying to see how exercise affects mood in people with bipolar disorder, major depression, and their healthy family members over two years.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT05669703

• Booster sessions of Dialectical Behavior Therapy for youth at risk for bipolar disorder

  This study is testing if extra Dialectical Behavior Therapy sessions can help young people who are at risk for bipolar disorder stay on track after finishing a full year of therapy.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05627492

• Training veterans with serious mental illness to improve social skills for work

  This study is testing a special training program to help veterans with serious mental illnesses improve their social skills for better job interactions.

  Recruiting VA Office of Research and Development · Minneapolis, Minnesota · NCT05491538

• Using cannabidiol to treat anxiety and depression in bipolar disorder

  This study is testing if a special CBD product can help people with bipolar disorder who also struggle with anxiety and depression feel better over four weeks.

  Recruiting Phase 2 Mclean Hospital · Belmont, Massachusetts · NCT05457465

• Naturalistic treatment and follow-up for youth with bipolar spectrum disorders

  This study looks at young people aged 9 to 19 with bipolar spectrum disorders to see how well they do over a year while receiving standard treatments and tracking their progress.

  Recruiting University of California, Los Angeles · Los Angeles, California and 3 other locations · NCT05427123

• Assessing Lithium Levels and Suicidal Behavior in Depressed Patients

  This study is testing whether the amount of lithium in the blood of people with major depression is linked to past suicidal thoughts or behaviors.

  Recruiting University Hospital, Montpellier · Montpellier · NCT05409794

• Dialectical behavior therapy for youth at risk for bipolar disorder

  This study is testing if dialectical behavior therapy can help young people aged 13 to 23 who are at risk for bipolar disorder learn important skills to manage their emotions and relationships.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05153382

• DBT-informed care for youth with bipolar disorder

  This study is testing a new way to help young people with bipolar disorder by using different levels of therapy based on their individual needs to see if it improves their emotional health and safety.

  Recruiting Centre for Addiction and Mental Health · Toronto, Ontario · NCT05153369

• Using neurofilament light chains to differentiate cognitive impairments in psychiatric and neurodegenerative diseases

  This study is testing if a specific protein in the blood can help tell the difference between cognitive problems caused by mental health issues and those caused by brain diseases like Alzheimer's or dementia.

  Recruiting at 2 sites Hôpital le Vinatier · Bron and 1 other locations · NCT04946916

• Improving sleep in bipolar patients using light therapy and education

  This study is testing if light therapy and education can help people with bipolar disorder sleep better and feel more stable.

  Recruiting Centre Hospitalier Henri Laborit · Poitiers · NCT04917419

• Registry for patients with treatment-resistant depression and OCD receiving interventional therapies

  This study is testing different treatments like ECT, TMS, and ketamine to see how they help people with treatment-resistant depression and OCD feel better.

  Recruiting University of Iowa · Iowa City, Iowa · NCT04480918

• Exploring time perception in schizophrenia and bipolar disorder using virtual reality

  This study is trying to see how people with schizophrenia and bipolar disorder experience time differently by using virtual reality games.

  Recruiting Institut National de la Santé Et de la Recherche Médicale, France · Strasbourg · NCT04432116

• Using brain stimulation to improve thinking skills in people with mental health conditions

  This study is testing if a brain stimulation treatment can help improve thinking skills in people with mental health conditions like depression, bipolar disorder, and ADHD.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT04296604

• Cognitive stimulation program for elderly patients with bipolar disorder

  This study is testing a special brain training program for older adults with bipolar disorder to see if it can help improve their thinking skills and reduce the chances of them having a relapse.

  Recruiting Groupe Hospitalier de la Rochelle Ré Aunis · La Rochelle · NCT04184375

• Comparing magnetic seizure therapy and electroconvulsive therapy for bipolar depression and treatment-resistant depression

  This study is testing whether magnetic seizure therapy works better than electroconvulsive therapy for people with bipolar depression who haven't found relief from other treatments.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT04080778

• Studying attention and reward sensitivity in adults with bipolar disorder

  This study is testing how attention and sensitivity to rewards affect adults with bipolar disorder to better understand their mental health challenges.

  Recruiting University Hospitals Cleveland Medical Center · Cleveland, Ohio · NCT03829787

• Genetic counselling to prevent mental health issues from cannabis use

  This study is trying to see if genetic counselling can help young people aged 12 to 21 understand their risk of mental health issues from cannabis use and make better choices about using it.

  Recruiting Nova Scotia Health Authority · Halifax, Nova Scotia · NCT03601026

• Cerebellar stimulation to improve cognitive function and mood

  This study is testing if a special brain stimulation can help improve thinking and mood in people with schizophrenia, autism, bipolar disorder, and Parkinson's disease.

  Recruiting University of Iowa · Iowa City, Iowa · NCT03217110

• Exploring the role of immune and genetic factors in bipolar disorder and schizophrenia

  This study is trying to see if certain immune and genetic factors related to a type of virus can help us understand and improve treatments for people with bipolar disorder and schizophrenia.

  Recruiting at 5 sites Fondation FondaMental · Créteil, France and 5 other locations · NCT02878408

• Registry for improving mental health care in the Maritimes

  This study is trying to improve mental health care for people with depression in the Maritimes by creating a registry that helps track treatments and outcomes while involving those who have experienced these challenges.

  Recruiting Nova Scotia Health Authority · Halifax, Nova Scotia · NCT02443636

• Preventive intervention for young people at risk of severe mental illness

  This study is testing a new program to help young people aged 9-21 who are at risk of serious mental illnesses by teaching them skills to manage early warning signs like anxiety and unusual experiences.

  Recruiting Nova Scotia Health Authority · Halifax, Nova Scotia and 1 other locations · NCT01980147

• Network for understanding Bipolar Disorder in Norway

  This study looks at different types of people with Bipolar Disorder in Norway to see how they are doing over time and what factors might affect their health.

  Recruiting Norwegian University of Science and Technology · Trondheim · NCT00201526

• Evaluation of patients with mood and anxiety disorders and healthy volunteers

  This study is looking for people with mood and anxiety disorders, as well as healthy volunteers, to see if they can help with research that aims to better understand these conditions.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT00024635

NIH-funded research (newest 40 of 43)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Detailed brain mapping for bipolar disorder and major depression

  Researchers are using thousands of MRI scans to map fine-grained brain structure differences in people with bipolar disorder and major depression compared with people without these conditions.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11512325

• Understanding how mood swings happen in bipolar disorder

  Researchers are testing a high-tech brain imaging approach to map how emotions flare and fade in people with bipolar disorder.

  NIH research Laureate Institute for Brain Research · Tulsa, United States · NIH-11413545

• Cerebellum and mood in bipolar disorder

  A long-term study will look at how the cerebellum’s signals and metabolism relate to mood changes in people with bipolar I and compare them with non-affected individuals.

  NIH research University of Iowa · Iowa City, United States · NIH-11408518

• Biological signs linked to alcohol problems in young people with bipolar disorder

  This project will look for brain and stress-related signs that predict which young people with bipolar disorder and their peers may go on to develop alcohol problems.

  NIH research University of Texas at Austin · Austin, United States · NIH-11332456

• Improving emotion control in bipolar disorder with rapid noninvasive brain stimulation

  This project uses short sessions of rapid, noninvasive brain stimulation aimed at a specific brain area to help people with bipolar disorder improve control over emotions.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11325293

• Finding genes linked to schizophrenia and bipolar disorder in Latino and mixed-ancestry people

  This project will combine genetic information and gene-activity (RNA) data from Latino people with schizophrenia, bipolar disorder, and people without these conditions to find genes that raise disease risk.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11319730

• Understanding how brain networks relate to decision-making in bipolar disorder

  A study of adults with bipolar disorder and healthy controls to see how brain network changes relate to how quickly people gather evidence to make decisions.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11300984

• Broadband near infrared scan to study brain mitochondrial activity in bipolar disorder

  A small study will use a noninvasive brain scan to see if a mitochondrial signal differs in people with bipolar disorder compared with healthy volunteers.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11288520

• Reward sensitivity, impulsive sensation seeking, and emotion regulation linked to bipolar risk in young adults

  This project looks for brain patterns tied to reward, impulsivity, and emotion control that can help spot young adults at risk for bipolar disorder rather than depression.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11257252

• How strong positive emotions relate to bipolar disorder in young adults

  This project follows emerging adults to find out whether intense or poorly controlled positive emotions predict who will develop or have worsening bipolar disorder.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-11239087

• Mapping brain structure in bipolar disorder and major depression

  This project uses thousands of brain scans to find detailed patterns in brain anatomy linked to bipolar disorder and major depression.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11235831

• Smartphone-based mood and emotion monitoring for bipolar disorder

  This project uses an Android app that passively tracks voice and behavior to spot mood and emotion changes in people with bipolar disorder.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11231253

• Identifying brain and behavior markers for bipolar disorder in youth

  This study is looking at young people who show early signs of bipolar disorder, like feeling really high or energetic, to find clues in their brain and behavior that might help doctors spot the condition sooner and provide better support.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11184809

• Cerebellum metabolism and mood changes in bipolar disorder

  Researchers will follow people with bipolar I and matched controls over two years to see how cerebellum chemistry, activity, and structure change when mood shifts.

  NIH research University of Iowa · Iowa City, United States · NIH-11177039

• Family Navigator Support for Teens with Bipolar Disorder

  A program that helps families of teens with bipolar disorder get quicker, smoother access to mental health services.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11139153

• Investigating the effects of a key gene on bipolar disorder and stress responses

  This study is looking at how a missing gene related to bipolar disorder affects brain function and stress responses in mice, which could help us understand more about what happens in the brains of people with bipolar disorder.

  NIH research Broad Institute, INC. · Cambridge, United States · NIH-11119400

• Improving emotion regulation in bipolar disorder using brain stimulation

  This study is looking at whether a special type of brain stimulation can help people with bipolar disorder better manage their emotions, and it’s for anyone who wants to find new ways to feel more stable and improve their daily life.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11105794

• Understanding the development of bipolar disorder in youth at risk

  This study is looking at how bipolar disorder starts in teens and young adults who have family members with the condition, focusing on how their genes and early life experiences might play a role, so we can better understand what helps or hinders their mental health as they grow up.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11092149

• Early support to lower bipolar risk in children of parents with bipolar disorder

  An adapted therapy that helps stabilize sleep and daily rhythms for children and teens who have a parent with bipolar disorder to try to lower their chances of developing bipolar themselves.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11089454

• Investigating how light sensitivity affects sleep and mood in bipolar disorder

  This study is looking at how being sensitive to light might affect sleep, mood, and energy levels in people with bipolar disorder, and it hopes to find ways to improve treatment based on these findings.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11079479

• A program to help individuals with bipolar disorder reduce tobacco use through future thinking.

  This study is testing a new program called 'Future Self-BD' to help people with bipolar disorder who want to quit smoking by imagining positive future outcomes from stopping, and it aims to see how well the program works and if it's easy to use.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11077784

• Understanding how the brain processes information in bipolar disorder

  This study is looking at how the brains of people with bipolar disorder gather information and make choices, and it will compare their brain activity to that of healthy individuals to see what differences exist.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11064023

• Mapping brain structure differences in bipolar disorder and major depression

  This study looks at how the brains of people with bipolar disorder and major depression are different from those of healthy individuals, using advanced imaging techniques to find specific brain patterns, which could help improve how we diagnose and treat these conditions.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11037814

• Identifying genetic factors for schizophrenia and bipolar disorder in diverse populations

  This study is looking at how genes might play a role in schizophrenia and bipolar disorder specifically in Latino individuals, and it will involve gathering information from 1,500 people, including those with these conditions and healthy individuals, to better understand how genetics can affect mental health and treatm

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11030780

• Investigating biological factors that may lead to alcohol use disorders in young adults with bipolar disorder.

  This study is looking at how certain biological factors and life experiences might lead to alcohol problems in young adults with bipolar disorder, using brain scans to see how things change over time, so we can find better ways to help those who are affected.

  NIH research University of Texas at Austin · Austin, United States · NIH-11026442

• Using smartphone apps to monitor mood changes in bipolar disorder

  This study is exploring how a new smartphone app can help people with bipolar disorder keep track of their moods in real-time, making it easier to understand their emotional ups and downs over six months without needing constant check-ins.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11000842

• Improving sleep patterns in people with bipolar disorder

  This study is looking at how fixing sleep patterns with a mix of low-dose afternoon melatonin and a regular sleep schedule can help adults with bipolar disorder feel better and sleep more soundly.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10996157

• Understanding positive emotions in young adults with bipolar disorder

  This study is looking at how difficulties with managing positive emotions might influence the start and development of bipolar disorder in young adults, and it’s for people who are at high risk, recently diagnosed, or at low risk for the condition.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-10994670

• Understanding brain mechanisms that predict bipolar disorder in young adults

  This study is looking at how brain activity and structure can help spot young adults who might be at risk for bipolar disorder instead of just major depression, with the hope of finding ways to prevent these conditions from developing.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-10989966

• Investigating genetic factors linked to schizophrenia and bipolar disorder

  This study is looking at the genes that might play a role in schizophrenia and bipolar disorder to help us understand how these conditions develop, which could lead to better treatments for those affected.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10974473

• Investigating brain inflammation's impact on executive function in bipolar disorder

  This study is looking at how inflammation in the brain might impact thinking skills, especially the ability to control impulses, in people with bipolar disorder, and by joining in, you could help us find new ways to improve these skills for better mood management.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10954718

• Understanding how daily biological rhythms affect bipolar disorder

  This study is looking at how the body's internal clock affects mood and anxiety in people with bipolar disorder, hoping to find out how changes in this clock might lead to mood swings and stress.

  NIH research University of Mississippi Med Ctr · Jackson, United States · NIH-10925269

• Investigating brain circuitry related to alcohol use and bipolar disorder

  This study is looking at how the brain's reward system works in people who have both alcohol use disorder and bipolar disorder, along with their children who don't have these conditions, to help find better treatments for everyone involved.

  NIH research Medical University of South Carolina · Charleston, United States · NIH-10912002

• Understanding how emotions affect impulsivity in bipolar disorder

  This study is looking at how feelings can affect impulsive actions in adults with bipolar disorder, using special brain scans and real-time check-ins to understand what's happening in the brain during emotional moments, with the hope of finding better ways to help manage impulsivity.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10901978

• Identifying brain targets for treating mood disorders in bipolar patients

  This study is looking at how a treatment called transcranial magnetic stimulation (TMS) can be improved for people with bipolar disorder by finding the best spots in the brain to help with mood swings, and it involves some brain scans and tests to make sure the chosen spots are effective.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10896349

• Investigating the genetics of bipolar disorder in Pakistan

  This study is looking at the genes that might play a role in bipolar disorder, and it's inviting people with the condition to help researchers learn more so that better treatments can be developed in the future.

  NIH research Rutgers, the State Univ of N.j. · Piscataway, United States · NIH-10841617

• Improving medication adherence and blood pressure control in people with hypertension and bipolar disorder

  This study is looking at how sending personalized text messages can help people with bipolar disorder remember to take their blood pressure medications, making it easier for them to manage both their mental and physical health.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10837895

• Using financial activity data to understand behavior in bipolar disorder

  This study is looking at how bipolar disorder affects money habits, especially when symptoms are active, and it wants to help people with bipolar disorder make better financial choices by understanding their spending patterns.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-10835013

• Understanding how brain circuits related to emotions and appetite are affected in bipolar disorder

  This study is looking at how certain brain cells in the amygdala affect emotions and appetite in people with bipolar disorder, hoping to find out how they work differently than in those without the condition, which could help improve treatments for managing feelings and behaviors.

  NIH research Mclean Hospital · Belmont, United States · NIH-10798197

• Finding the best tools for managing bipolar disorder in clinical care

  This study is looking to find the best tools for patients and doctors to track bipolar disorder symptoms, so they can work together to improve care and see how regular check-ins compare to usual treatment.

  NIH research University of Washington · Seattle, United States · NIH-10794406

Related topics

Quick answers

How many Bipolar Disorder clinical trials are recruiting right now?

71, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 24 countries. The most sites are in United States (31 trials), France (14 trials), Canada (8 trials), China (5 trials), Turkey (Türkiye) (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 3, Phase 4: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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