Improving emotion regulation in bipolar disorder using brain stimulation
Targeting Emotion Regulation in Bipolar Disorder with Intermittent Theta Burst Stimulation: A Mechanistic Study
This study is looking at whether a special type of brain stimulation can help people with bipolar disorder better manage their emotions, and it’s for anyone who wants to find new ways to feel more stable and improve their daily life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11105794 on NIH RePORTER |
What this research studies
This research investigates how a specific type of brain stimulation, called accelerated intermittent theta-burst stimulation (aiTBS), can enhance emotion regulation in individuals with bipolar disorder. By targeting the inferior parietal lobule, a brain region involved in managing emotions, the study aims to assess changes in brain connectivity and behavior related to emotion regulation. Participants will undergo brain imaging and perform tasks to evaluate the effectiveness of this treatment compared to a placebo. The goal is to develop rapid-acting alternatives that can help stabilize mood and improve daily functioning for those affected by bipolar disorder.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with bipolar disorder who experience significant challenges with emotion regulation.
Not a fit: Patients who do not have bipolar disorder or those who are not experiencing difficulties with emotion regulation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, effective treatments that help individuals with bipolar disorder better manage their emotions and improve their quality of life.
How similar studies have performed: Previous research has shown promise in using brain stimulation techniques for mood disorders, suggesting that this approach may be effective, though this specific application is novel.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Ellard, Kristen K — Massachusetts General Hospital
- Study coordinator: Ellard, Kristen K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.