Investigating the link between Frontotemporal Dementia and Bipolar Disorder using neuroimaging and epigenetics

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to explore the epigenetic modifications affecting brain morphology and functionality in patients with behavioral variant Frontotemporal Dementia (bvFTD) and Bipolar Disorder (BD). It is an open-label, multicentric, interventional case-control study that will analyze three cohorts: bvFTD patients, BD patients, and healthy controls. Participants will undergo blood sample collection for RNA analysis and neuroimaging sessions to assess brain structure and function. The study will include both existing and prospectively recruited patients over a two-year follow-up period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* byFTD group: patients of either sex; 18 years of age or older; diagnosis of behavioral variant Frontotemporal Dementia according to current diagnostic criteria; presence of a signed informed consent.
* BD group: patients of either sex; 18 years of age or older; diagnosis of bipolar disorder according to DSM-V criteria; presence of a signed informed consent.
* HC group: patients of either sex; 18 years of age or older; subjects who have gone through the same diagnostic process as patients under suspicion of a central nervous system and/or psychiatric disorder, resulting in the absence of cognitive deficits and mood disorders; presence of a signed informed consent.

Exclusion Criteria:

* Diagnosis of Alzheimer's disease
* Comorbidities interfering with the studied condition (e.g. other neurological diseases or history of substance or alcohol abuse)
* Diseases with an inflammatory component (e.g. autoimmune diseases, tumors)
* Pregnancy

Where it's running

• Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico
  Milan, Mi, Italy Recruiting

Study contacts

• Principal investigator: Elio Scarpini, Professor — UOSD Malattie Neurodegenerative
• Study coordinator: Paolo Brambilla, Professor
• Email: paolo.brambilla@policlinico.mi.it
• Phone: 02 55035982

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.